Comparison of oncologic outcomes between sarcomatoid and clear cell renal cell carcinoma

Trudeau, Vincent; Larcher, Alessandro; Sun, Maxine; Boehm, Katharina; Dell’Oglio, Paolo; Sosa, José; Tian, Zhe; Fossati, Nicola; Briganti, Alberto; Shariat, Shahrokh F.; Karakiewicz, Pierre I.

doi:10.1007/s00345-016-1780-z

Cited by 21 publications

(23 citation statements)

References 13 publications

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“…Sarcomatoid differentiation is currently considered a rare histologic variant that predicts aggressive behaviour and poor prognosis. According to previous studies, RCC with sarcomatoid differentiation more frequently has larger tumour size, higher risk of necrosis and higher tumour stage and grade [6,7,16], which is consistent with the results of our study. In our cohort of RCC with vena caval tumour thrombus treated surgically, the presence of sarcomatoid differentiation in RCC was found to be an independent predictor for PFS and CSS after adjusting for other known prognostic factors.…”

Section: Discussionsupporting

confidence: 93%

“…The association between sarcomatoid differentiation with poor oncologic outcomes has been consistently confirmed by many previous studies [5,6,16,17]. Using the Surveillance, Epidemiology, and End Results-Medicare database, Trudeau et al [7] identified one of the largest RCC cohorts including 234 RCCs with sarcomatoid differentiation. The results of that study showed that RCC with sarcomatoid differentiation has a worse 5-year CSS compared to pure clear cell RCC (67% vs 14%).…”

Section: Discussionmentioning

confidence: 78%

“…Approximately 5% of all RCCs and up to 15% of stage IV cases contain sarcomatoid differentiation [5,6]. Previous studies suggested that sarcomatoid differentiation is associated with aggressive behaviours, poor response to targeted therapy and worse prognosis [6][7][8]. However, the impact of sarcomatoid differentiation on prognosis for RCC with vena caval tumour thrombus treated surgically has not been studied extensively.…”

Section: Introductionmentioning

confidence: 99%

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Impact of sarcomatoid differentiation and rhabdoid differentiation on prognosis for renal cell carcinoma with vena caval tumour thrombus treated surgically

Yang

et al. 2020

BMC Urol

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Background: Sarcomatoid differentiation in renal cell carcinoma (RCC) with vena caval tumour thrombus has been shown to be associated with aggressive behaviours and poor prognosis; however, evidence of the impact of rhabdoid differentiation on prognosis is lacking. This study evaluated the impact of sarcomatoid differentiation and rhabdoid differentiation on oncological outcomes for RCC with vena caval tumour thrombus treated surgically. Methods: We retrospectively analysed patients treated surgically for RCC with vena caval tumour thrombus at our institute from Jan 2015 to Nov 2018. Prognostic variables were evaluated for associations with progression-free survival (PFS) and cancer-specific survival (CSS) by Kaplan-Meier survival analysis and log-rank test. Univariate and multivariate analyses were performed to determine independent prognostic variables. Results:We identified 125 patients with RCC and vena caval tumour thrombus, including 17 (13.6%) with sarcomatoid differentiation alone, 8 (6.4%) with rhabdoid differentiation alone and 3 (2.4%) with both sarcomatoid and rhabdoid differentiation. Compared to pure RCC, patients with sarcomatoid differentiation but not rhabdoid differentiation have worse PFS (p = 0.018 and p = 0.095, respectively). The univariate and multivariate analyses both showed sarcomatoid differentiation as a significant predictor of PFS. Compared to pure RCC, patients with sarcomatoid differentiation (p = 0.002) and rhabdoid differentiation (p = 0.001) both had significantly worse CSS. The univariate analysis showed sarcomatoid differentiation, rhabdoid differentiation, metastasis and blood transfusion as significant predictors of CSS (All, p < 0.05). In the multivariate analysis, sarcomatoid differentiation (HR 3.90, p = 0.008), rhabdoid differentiation (HR 3.01, p = 0.042), metastasis (HR 3.87, p = 0.004) and blood transfusion (HR 1.34, p = 0.041) all remained independent predictors of CSS.Conclusions: Sarcomatoid differentiation and rhabdoid differentiation are both independent predictors of poor prognosis in RCC with vena caval tumour thrombus treated surgically.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

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Impact of sarcomatoid differentiation and rhabdoid differentiation on prognosis for renal cell carcinoma with vena caval tumour thrombus treated surgically

Yang

et al. 2020

BMC Urol

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“…As we know, histologic subtype was a prognostic indicator for kidney cancer survival . Compared with clear cell renal cell carcinoma, patients with sarcomatoid renal cell carcinoma and collecting duct renal cell carcinoma had worse overall survival and cancer‐specific survival . Conversely, patients with chromophobe histology had improved survival .…”

Section: Discussionmentioning

confidence: 99%

“…19 Compared with clear cell renal cell carcinoma, patients with sarcomatoid renal cell carcinoma and collecting duct renal cell carcinoma had worse overall survival and cancer-specific survival. 44,45 Conversely, patients with chromophobe histology had improved survival. 45 Based on our study, there was no significant difference in suicide rates among patients with different histologic subtypes, and no apparent association between histologic subtype and suicide was found by Cox regression modeling.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with suicide among kidney cancer patients: A Surveillance, Epidemiology, and End Results analysis

et al. 2019

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Background The suicide risk was higher in kidney cancer patients than in the general population. The purpose of this study was to characterize the suicide rates among kidney cancer patients and to identify the potential risk factors associated with suicide from the Surveillance, Epidemiology, and End Results (SEER) database. Methods Kidney cancer patients were identified from the SEER database during 1973‐2015. Suicide rates and standardized mortality ratios (SMRs) of this population were calculated, and the US general population during 1981‐2015 was chosen as a reference. Univariable and multivariable Cox regression were performed to find out potential risk factors of suicide. Results There were 207 suicides identified among 171 819 individuals with kidney cancer observed for 948 272 person‐years. The suicide rate was 21.83 per 100 000 person‐years, and SMR was 1.83 (95% CI: 1.59‐2.10). On Cox regression, diagnosis in early years (1973‐1982 vs 2003‐2015, HR: 2.03, 95% CI: 1.01‐4.11, P = 0.048; 1983‐1992 vs 2003‐2015, HR: 1.99, 95% CI: 1.18‐3.35, P = 0.010), male sex (vs female sex, HR: 4.43, 95% CI: 2.95‐6.65, P < 0.001), unmarried status (vs married status, HR: 2.54, 95% CI: 1.91‐3.38, P < 0.001), non‐black race (white race vs black race, HR: 4.47, 95% CI: 2.09‐9.58, P < 0.001; other races vs black race, HR: 3.01, 95% CI: 1.08‐8.37, P = 0.035), higher histologic grade (grade IV vs grade I, HR: 3.27, 95% CI: 1.50‐7.13, P = 0.003; grade III vs grade I, HR: 2.13, 95% CI: 1.19‐3.81, P = 0.011) and cancer‐directed surgery not performed (vs performed, HR: 2.78, 95% CI: 1.52‐5.11, P < 0.001) were independent risk factors of suicide among kidney cancer patients. Conclusions Diagnosis in early years, male sex, unmarried status, non‐black race, higher histologic grade, and cancer‐directed surgery not performed were significantly associated with suicide among kidney cancer patients. In order to prevent suicidal death, clinicians should pay more attention to patients with high‐risk factors of suicide.

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Renal cell carcinoma and venous tumor thrombus: predicting sarcomatoid dedifferentiation through preoperative IVIM-based MR imaging

Zhao,

Ding,

Zhou

et al. 2024

Abdom Radiol

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Comparison of oncologic outcomes between sarcomatoid and clear cell renal cell carcinoma

Abstract: Patients with sRCC are present with more advanced disease. Moreover, sRCC is associated with a higher rate of CSM, even after adjusting for several characteristics and OCM.

Cited by 21 publications

References 13 publications

Impact of sarcomatoid differentiation and rhabdoid differentiation on prognosis for renal cell carcinoma with vena caval tumour thrombus treated surgically

Impact of sarcomatoid differentiation and rhabdoid differentiation on prognosis for renal cell carcinoma with vena caval tumour thrombus treated surgically

Risk factors associated with suicide among kidney cancer patients: A Surveillance, Epidemiology, and End Results analysis

Renal cell carcinoma and venous tumor thrombus: predicting sarcomatoid dedifferentiation through preoperative IVIM-based MR imaging

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