Roles of microRNA-124a and microRNA-30d in breast cancer patients with type 2 diabetes mellitus

Zhang, Shu; Guo, L. Jay; Zhang, Gang; Wang, Lingli; Hao, Shuai; Gao, Bo; Jiang, Yan; Tian, Wuguo; Cao, Xian-E; Luo, Dong-Hua

doi:10.1007/s13277-016-4981-6

Cited by 18 publications

(14 citation statements)

References 29 publications

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“…Moreover, there is convincing evidence that miR-30d serves as a novel prognostic biomarker in breast cancer in patients with type 2 diabetes mellitus. 14,15 Consistent these results, we found that miR-30d was increased in breast cancer cell lines and miR-30d overexpression promotes cell growth and metastasis whilst inhibiting cell apoptosis.…”

Section: Discussionsupporting

confidence: 82%

“…Evidence indicated that the expression of miR‐30d was increased in multiple types of cancers, including breast cancer with type 2 diabetes mellitus . Firstly, we found that miR‐30d expression was markedly increased in breast cancer cell lines BT474, MDA‐MB‐231, HCC197, and MDA‐MB‐468 compared with the control normal cells MCF‐10A (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…[11][12][13] miR-30d and miR-124a were reported to serve as novel prognostic biomarkers and therapeutic targets of breast cancer in patients with type 2 diabetes mellitus. 14,15 It is shown by other studies that the miR-30 microRNA family (miR-30a, -30b, -30c-1, -30c-2,-30d, -30e) is extensively expressed in multiple cancer cells and plays diverse roles in regulating tumor growth and metastasis. 16 miR-30a and -30d were reported as tumor suppressors in lung cancer, and miR-30a silences suppressed ovarian cancer cell proliferation and migration; moreover, miR-30d promoted melanoma cell invasion and immunosuppression.…”

Section: Introductionmentioning

confidence: 99%

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microRNA‐30d mediated breast cancer invasion, migration, and EMT by targeting KLF11 and activating STAT3 pathway

Han

Wang²,

Guo³

et al. 2018

J of Cellular Biochemistry

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miR-30d has been shown to play pivotal roles in cancer development, and has the potential to act as a diagnostic biomarker and therapeutic target in breast cancer. However, the specific function and molecular mechanism of miR-30d in breast cancer cell growth and metastasis is still unknown. The present study seeks to shed light on the potential contribution of the MiR-30d-KLF-11-STAT3 pathway in breast cancer. The results revealed that miR-30d levels were markedly increased in the breast cancer cell lines BT474, MDA-MB-231, HCC197, and MDA-MB-468 compared with the non-tumor mammary gland MCF10A cell line. Furthermore, the miR-30d mimic increased BT474 and MDA-MB-231 breast cancer cell survival, inhibited apoptosis and increased Bcl-2 expression, whilst inhibited Bax protein levels. miR-30d mimics promote BT474 and MDA-MB-231 cell migration, invasion, and mediate the EMT phenotype. However, miR-30d inhibitors reverse all of the effects of miR-30d mimics on breast cancer cell biology. Also, we observed that KLF-11 is a direct target of miR-30d and KLF-11 and pSTAT3 expression are determined by miR-30d. Finally, the results suggest that miR-30d plays essential roles in breast cancer cells in a manner that is dependent on the levels of KLF-1 and pSTAT3. In summary, miR-30d appears to be a novel diagnostic biomarker and treatment target in breast cancer.

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Section: Discussionsupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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microRNA‐30d mediated breast cancer invasion, migration, and EMT by targeting KLF11 and activating STAT3 pathway

Han

Wang²,

Guo³

et al. 2018

J of Cellular Biochemistry

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“…MiR-3202 could promote endothelial cell apoptosis by directly targeting Fas apoptotic inhibitory molecule 2 (FAIM2) gene in high glucose condition [Huang et al, 2017]. The miR-124a expression is reduced while miR-30d expression is increased, which showing that miR-124a and miR-30d may be associated with clinicopathological characteristics of breast cancer patients with type 2 diabetes mellitus (T2DM) [Zhang et al, 2016]. Similarly, in the current study, the level of miR-106b is obviously decreased in diabetic mice and NIT-1 cells with high glucose induction.…”

Section: Discussionmentioning

confidence: 99%

Berberine Alleviates Oxidative Stress in Islets of Diabetic Mice by Inhibiting miR‐106b Expression and Up‐Regulating SIRT1

Chen

Yang

2017

J of Cellular Biochemistry

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Mounting studies have indicated the role of berberine, SIRT1, and oxidative stress in diabetes, respectively. However, few studies have demonstrated their correlation and regulation function in diabetes. Therefore, the protective effect of berberine in diabetic and the underlying core mechanism were investigated in the current study. Diabetic mice model in vivo were established. Mouse pancreatic beta-cell line NIT-1 cells were treated with 30 mM high glucose to induce diabetic condition in vitro. Serum biochemical parameters (glucose, total cholesterol, and triglycerides) were detected. Oxidative stress indicators (MDA, SOD1), along with miR-106b and SIRT1 expression in islets and cells were also assessed. Direct targeting relationship between miR-106b and SIRT1 was discussed by dual luciferase reporter gene assay. Diabetic model in vivo and in vitro were both established successfully. The expression of serum biochemical parameters was increased, and oxidative stress parameters, and miR-106b, SIRT1 were abnormally expressed in diabetic mice and NIT-1 cells. Meanwhile, berberine could alleviate oxidative stress injury in diabetic progression. Through dual luciferase reporter gene assay, we found that SIRT1 was a target gene of miR-106b. In addition, miR-106b over-expression could reverse the protection of berberine in NIT-1 cells against from oxidative stress induced by high glucose. Berberine could attenuate oxidative stress of diabetic mice at least partly through miR-106b/SIRT1 pathway and affecting the function of islets, which might be beneficial in reducing the cardiovascular risk factors in diabetes. J. Cell. Biochem. 118: 4349-4357, 2017. © 2017 Wiley Periodicals, Inc.

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“…Documents have been accumulated to investigate the expression and role of other members of miR-30 family in human cancers [119-123]. As shown in Table 2, miR-30 family members were involved in processes of cancer development, concluding proliferation, migration, invasion, EMT, metastasis, autophagy and apoptosis through distinguished targets [124-126].…”

Section: Activities Of Mir-30a In Cancer Progressionmentioning

confidence: 99%

The Versatile Role of microRNA-30a in Human Cancer

Xiang

Chen²,

Chen³

2017

Cell Physiol Biochem

2,603

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MicroRNAs (miRNAs) are a group of noncoding RNA molecules of 20-23 nucleotides length that negatively regulate gene expressions in numerous cellular processes. Through complementary paring with target mRNAs, miRNAs have frequently emerged as dual regulators of cancer development by acting on multiple signaling pathways, thereby act as novel biomarkers for cancer diagnosis, prognosis, and prediction of response to treatment. As one of them, miR-30a has been found to act as an onco-suppressor of tumorigenesis pathways through inhibition of cellular proliferation, migration and invasion. Simultaneously, miR-30a plays a progressing role in several types of cancer, determined by relevant target genes as well. In the present review, we summarize recent research regarding miR-30a, including its biological function, expression and regulation, especially focusing on its role in cancer development and progression. Clinically, miR-30a may serve as a potential target in the diagnosis and therapy of human cancer.

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Roles of microRNA-124a and microRNA-30d in breast cancer patients with type 2 diabetes mellitus

Cited by 18 publications

References 29 publications

microRNA‐30d mediated breast cancer invasion, migration, and EMT by targeting KLF11 and activating STAT3 pathway

microRNA‐30d mediated breast cancer invasion, migration, and EMT by targeting KLF11 and activating STAT3 pathway

Berberine Alleviates Oxidative Stress in Islets of Diabetic Mice by Inhibiting miR‐106b Expression and Up‐Regulating SIRT1

The Versatile Role of microRNA-30a in Human Cancer

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