Numerical modeling of experimental human fibrous cap delamination

Leng, Xiaochang; Davis, Lindsey A.; Deng, Xiaomin; Sutton, Michael A.; Lessner, Susan M.

doi:10.1016/j.jmbbm.2016.02.011

Cited by 11 publications

(18 citation statements)

References 39 publications

(46 reference statements)

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“…This study focuses on the comparison of four different shapes (triangular, trapezoidal, linear-exponential, and exponential-linear) of CZM in modeling the arterial medial layer peeling. Meanwhile, as a continuation of the previous studies, four types of CZM laws are used to model the delamination fracture of atherosclerotic plaque and fibrous cap [14,15]. The findings of this study will help to study the influence of cohesive law shapes on the tearing propagation behavior in the medial layer of the arterial tissue.…”

Section: Introductionmentioning

confidence: 80%

“…The aim of this study is to compare the four different shapes (triangular, trapezoidal, linear-exponential, and exponential-linear) of the CZM in modeling the arterial medial layer peeling (Figures 3 and 4). Moreover, four types of CZM laws were used to model the delamination of atherosclerotic plaque [14] ( Figure 5) and fibrous cap [15] ( Figure 6).…”

Section: Results Comparison and Discussionmentioning

confidence: 99%

“…For the human fibrous cap delamination test, as shown in Figure 2e, the delamination of human fibrous cap presents as a pair of micro-clamps. The sequential loading-delamination-unloading cycles are applied to make the fibrous cap separate from the underlying plaque tissue [15]. Although there are three types of delamination experiments, the HGO models and CZM models used for the simulation are the same, except for the human aortic media delamination test (including viscoelastic material model parameters for human arterial tissue) and the material parameter values for the three cases.…”

Section: Arterial Tissue Delaminationmentioning

confidence: 99%

“…The peeling path is obtained from the experimental observations of this study. Meanwhile, the experimental setup and simulation modeling details of the mouse plaque delamination and human fibrous cap delamination processes are presented in references [14,15].…”

Section: Arterial Wall Delamination Modeling Using Czmsmentioning

confidence: 99%

“…The value of the interfacial stiffness K was assigned as the same one from reference [14]. With regard to the simulations of the mouse plaque delamination processes, the material parameter values for the HGO and CZM models were adopted from reference [14] and those values of the human fibrous cap delamination were obtained from reference [15] (including viscoelastic material model parameters for human arterial tissue), as shown in Table 1.…”

Section: Parameter Selection In Modelingmentioning

confidence: 99%

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A comparative study of cohesive zone models for predicting delamination fracture behaviors of arterial wall

et al. 2020

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Arterial tissue delamination, manifested as the fracture failure between arterial layers, is an important process of the atherosclerotic plaque rupture, leading to potential life-threatening clinical consequences. Numerous models have been used to characterize the arterial tissue delamination fracture failure. However, only a few have investigated the effect of cohesive zone model (CZM) shapes on predicting the delamination behavior of the arterial wall. In this study, four types of CZMs (triangular, trapezoidal, linear–exponential, and exponential–linear) were investigated to compare their prediction of the arterial wall fracture failure. The Holzapfel–Gasser–Ogden (HGO) model was adopted for modeling the mechanical behavior of the aortic bulk material. The CZMs optimized during the comparison of the aortic media delamination simulations were also used to perform the comparative study of the mouse plaque delamination and human fibrous cap delamination. The results show that: (1) the numerical predicted the relationships of force–displacement in the delamination behaviors based on the triangular, trapezoidal, linear–exponential, and exponential–linear CZMs match well with the experimental measurements. (2) The traction–separation relationship results simulated by the four types of CZMs could react well as the corresponding CZM shapes. (3) The predicted load–load point displacement curves using the triangular and exponential–linear CZMs are in good agreement with the experimental data, relative to the other two shapes of CZMs. All these provide a new method combined with the factor of shape in the cohesive models to simulate the crack propagation behaviors and can capture the arterial tissue failure response well.

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Section: Introductionmentioning

confidence: 80%

Section: Results Comparison and Discussionmentioning

confidence: 99%

Section: Arterial Tissue Delaminationmentioning

confidence: 99%

Section: Arterial Wall Delamination Modeling Using Czmsmentioning

confidence: 99%

Section: Parameter Selection In Modelingmentioning

confidence: 99%

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A comparative study of cohesive zone models for predicting delamination fracture behaviors of arterial wall

et al. 2020

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Finite‐element simulation of in‐plane tear propagation in the dissected aorta: Implications for the propagation mechanism

Han

Guo

Gao

et al. 2023

Numer Methods Biomed Eng

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Computer modeling and numerical simulation are essential for understanding the progression of aortic dissection. However, tear propagation has not been properly modeled and simulated. The in‐plane dissection propagation between concentrically distributed elastic lamellae is modeled using the cohesive zone method with a bilinear traction‐separation law. The parameters of cohesive elements are calibrated for the three modes of interfacial damage in the media, enabling quantitative predictions of in‐plane tear propagation. An idealized cylindrical tube‐shaped bilayer thick‐wall model of the aorta is employed to elucidate the influence of geometrical parameters, loading conditions and residual stress on the tear propagation. While the model is capable of replicating that deeper, larger tears are associated with lower critical pressure, new findings include: (i) Larger axial stretch leads to lower critical pressure; (ii) Increased magnitude of residual stress is associated with higher critical pressure; (iii) Pressure difference between true and false lumen alters the critical pressure; (iv) The interfacial damage is mostly opening mode in the axial direction, but shear‐dominated in the circumferential direction; (v) Damage due to the opening mode is associated with smaller fracture energy, which makes it easier to propagate than the shear and the mixed modes. (vi) The deformed shape of the tear, which is related to its geometrical features and loading conditions, modulates the critical pressure via two pathways: (a) deformed shapes are associated with specific modes of damage, which influences the critical pressure, and (b) deformed shapes modulate the critical pressure directly via geometrical constraints.

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Mechanical and structural contributions of elastin and collagen fibers to interlamellar bonding in the arterial wall

Wang

Zhang

2020

Biomech Model Mechanobiol

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Numerical modeling of experimental human fibrous cap delamination

Cited by 11 publications

References 39 publications

A comparative study of cohesive zone models for predicting delamination fracture behaviors of arterial wall

A comparative study of cohesive zone models for predicting delamination fracture behaviors of arterial wall

Finite‐element simulation of in‐plane tear propagation in the dissected aorta: Implications for the propagation mechanism

Mechanical and structural contributions of elastin and collagen fibers to interlamellar bonding in the arterial wall

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