Antioxidant and hyaluronidase inhibitory activities of diverse phenolics in <i>Phyllanthus emblica</i>

Xu, Min; Zhu, Hongtao; Cheng, Rong-Rong; Wang, Dong; Yang, Chong‐Ren; Tanaka, Takashi; Kouno, Isao; Zhang, Yingjun

doi:10.1080/14786419.2015.1137573

Cited by 19 publications

(3 citation statements)

References 15 publications

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“…The methanolic extracts of Malaxis acuminate leaves and stems exhibited photo protective activity against UV-A and UV-B radiation in addition to acting as HAase inhibitors. GC-MS of both leaf and stem extracts showed the presence of phenolic acids, sterols, α-hydroxy acids, amino acids, sugars, and glycosides which coincides with the use of M. acuminata as a rejuvenating remedy in several Ayurvedic formulations [19]. The n-butanol, aqueous and methanol extracts of Pleurotus citrinopileatus were also found to act as hyaluronidase inhibitors by 9.7%, 10.8%, and 25.4%, at concentrations of 2.0, 1.1, and 4.1 mg/mL, respectively, the aqueous and methanolic extract of Pleurotus tuber-regium showed hyaluronidase inhibition by 22.19% and 3.94%, respectively, at 100 µg/mL while Trametes lactinea aqueous and acetonic extract inhibited hyaluronidase by 88.6% and 88.3%, respectively [6].…”

Section: Introductionsupporting

confidence: 53%

Bioassay-Guided Isolation, Metabolic Profiling, and Docking Studies of Hyaluronidase Inhibitors from Ravenala madagascariensis

Mohamed¹,

Hetta

Rateb

et al. 2020

Molecules

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Hyaluronidase enzyme (HAase) has a role in the dissolution or disintegration of hyaluronic acid (HA) and in maintaining the heathy state of skin. Bioassay-guided fractionation of Ravenala madagascariensis (Sonn.) organ extracts (leaf, flower, stem, and root) testing for hyaluronidase inhibition was performed followed by metabolic profiling using LC–HRMS. Additionally, a hyaluronidase docking study was achieved using Molecular Operating Environment (MOE). Results showed that the crude hydroalcoholic (70% EtOH) extract of the leaves as well as its n-butanol (n-BuOH) partition showed higher HAase activity with 64.3% inhibition. Metabolic analysis of R. madagascariensis resulted in the identification of 19 phenolic compounds ranging from different chemical classes (flavone glycosides, flavonol glycosides, and flavanol aglycones). Bioassay-guided purification of the leaf n-BuOH partition led to the isolation of seven compounds that were identified as narcissin, rutin, epiafzelechin, epicatechin, isorhamnetin 7-O-glucoside, kaempferol, and isorhamnetin-7-O-rutinoside. The docking study showed that narcissin, rutin, and quercetin 3-O-glucoside all interact with HAase through hydrogen bonding with the Asp111, Gln271, and/or Glu113 residues. Our results highlight Ravenala madagascariensis and its flavonoids as promising hyaluronidase inhibitors in natural cosmetology preparations for skin care.

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Section: Introductionsupporting

confidence: 53%

Bioassay-Guided Isolation, Metabolic Profiling, and Docking Studies of Hyaluronidase Inhibitors from Ravenala madagascariensis

Mohamed¹,

Hetta

Rateb

et al. 2020

Molecules

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“…Bhumi Amalaki has been observed to possess anti-viral and anti-bacterial properties,[ 20 ] protective effect on the liver,[ 21 ] anti-oxidant and anti-inflammatory properties,[ 22 ] and as an immunomodulator. [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

Role of Ayurveda treatment in the management of hepatitis B (Ubhayapatha Ashrita Swatantra Kamala)- A case report

Varsakiya

Goyal

Kumari

et al. 2022

AYU

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Hepatitis B is one of the most common causes of liver disease, and due to unawareness of the safety measures, more prone to spread. As per the World Health Organization, for the South East Asia region, its prevalence is 2%. Yellowish discoloration of the eyes, body, and urine, abdominal discomfort, and vomiting is its cardinal symptoms. In Ayurveda, this set of symptoms is known as Kamala . This case report illustrates the effectiveness of the Ayurveda treatment modality in a patient with a viral load of 3705.71 IU/ml, and the values of AST (aspartate aminotransferase) and alanine transaminase (ALT) were 140 IU/ml and 173 IU/ml, respectively. A 40-year-old female patient with a complaint of yellowish discoloration of urine, eyes, and skin with fatigue and irritability was diagnosed with Ubhayapatha Ashrita Swatantra Kamala . The patient was treated with Ayurveda drugs and Virechana Karma (therapeutic purgation). After the treatment for 13 months, the disease was cured. Improvement was observed based on hepatitis B virus deoxyribonucleic acid (DNA) polymerase chain reaction (PCR) (hepatitis B DNA PCR) (decreased from 3705.71 IU/ml to <50.0 IU/ml) and the values of AST (decreased from 140 IU/ml to 19.0 IU/ml) and ALT (decreased from 173 IU/ml to 28 IU/ml). The patient was stable and asymptomatic during the follow-up period of 4 months.

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“…Hydrolyzable tannins are the major bioactive components of the EOF and the most abundant hydrolyzable tannin is β-glucogallin (Figure 3A) [31,32]. The other important bioactives reported in EOF include galloyl glucoses, gallic acids and its esters, mucic acid and their gallates, galloylated mucic acid lactones, various acids, flavonols and related compounds, and other tannins [18,[33][34][35][36][37][38] (Figure 3A-C). Furthermore, some earlier studies claimed that the fruits of E. officinalis contain two more hydrolyzable tannins, emblicanin A and emblicanin B [39].…”

Section: Major Phytochemicals (Bioactive Components) In Eofmentioning

confidence: 99%

Super Fruit Amla (Emblica officinalis, Gaertn) in Diabetes Management and Ensuing Complications: A Concise Review

Majeed

Narayanan

Mundkur³

et al. 2023

Nutraceuticals

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease showing an exponential increase in its prevalence all over the world. High blood glucose level is one of the main clinical signs of the disease. Although several classes of drugs are available for treatment, their prolonged use and adverse effects behoove the use of alternative medicine. Plant-derived natural products have multifaceted beneficial roles in human pathophysiology. Plant metabolites like tannins, organic acids, polyphenols, terpenes, and flavonoids show multiple mechanisms of action against diabetes. The fruits of Emblica officinalis (EOF), also known as Indian gooseberry (amla), contain several phytochemicals, potentially having anti-diabetic activity. Hydrolyzable tannins are the major bioactive components of the amla fruit, the most abundant hydrolyzable tannin being β-glucogallin. The present review summarizes the mechanism of action and clinical evidence for the beneficial effects of EOF on T2DM and its associated complications.

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Antioxidant and hyaluronidase inhibitory activities of diverse phenolics in Phyllanthus emblica

Cited by 19 publications

References 15 publications

Bioassay-Guided Isolation, Metabolic Profiling, and Docking Studies of Hyaluronidase Inhibitors from Ravenala madagascariensis

Bioassay-Guided Isolation, Metabolic Profiling, and Docking Studies of Hyaluronidase Inhibitors from Ravenala madagascariensis

Role of Ayurveda treatment in the management of hepatitis B (Ubhayapatha Ashrita Swatantra Kamala)- A case report

Super Fruit Amla (Emblica officinalis, Gaertn) in Diabetes Management and Ensuing Complications: A Concise Review

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