Chinese medicines with sedative–hypnotic effects and their active components

Shi, Man-Man; Piao, Jinhua; Xu, Xingyi; Zhu, Liang; Yang, Li; Fu, Lin; Chen, Jian; Jiang, Jian-Guo

doi:10.1016/j.smrv.2015.10.001

Cited by 53 publications

(34 citation statements)

References 30 publications

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“…Root of Scutellaria baicalensis , one of the component of HJD granule and having active ingredients of Baicalin , reported to have sedative-hypnotic effect by inhibition of release of glutamate. 27 From the systematic review of herbal medicine for insomnia based on pattern of Traditional Chinese Medicine (TCM), root of Scutellaria baicalensis and Fruit of Gardenia jasminoides were frequently used herbs for insomnia patients with ‘Liver-qi stagnation transforming into fire’; and Bark of Phellodendrom amurense and Rhizome of Coptis chinensis were used for insomnia patients with ‘Hyperactivity of fire due to yin deficiency’. 28 Crude herbs included in HJD granules were frequency used for insomnia related to fire/heat pattern in previous researches.…”

Section: Discussionmentioning

confidence: 99%

Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial

Choi

Kim

Kwon

et al. 2021

Integrative Medicine Research

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Background Huanglian-jie-du (HJD) granule, which is composed of representative “heat-clearing” herbs has been used for Hwa-byung . Hwa-byung is a culture-bound syndrome in Korea, characterized by distinct somatic symptoms such as chest congestion and heat sensation resulting from suppressed anger. We investigated the effect of HJD in patients with Hwa-byung . Methods Forty-four patients with Hwa-byung were recruited, and HJD or placebo granules were administered orally three times daily for seven days. The two primary outcomes were somatic symptoms, which were measured by Patient Health Questionnaire of physical symptoms (PHQ-15), and insomnia, which was measured by Insomnia Severity Index (ISI) at post-treatment. Results Between July 10 and October 31, 2017, 44 patients with Hwa-byung (mean age 36.68 years; and 38 female) were randomly assigned to HJD (n = 22) or placebo (n = 22) group. After administration of HJD or placebo granule for seven days, ISI score was lower in the HJD group compared to placebo group at post-treatment (adjusted mean difference -2.56 [95% CI -4.72 to -0.39], p = 0.0208). Meanwhile, there was no difference in PHQ-15 score between HJD group and placebo group at post-treatment (adjusted mean difference -0.50 [95% CI: -3.02–4.02], p = 0.7812). Conclusions Our results suggest that the administration of HJD granule has a potential to improve insomnia in Hwa-byung patients. Effect of HJD granule for general somatic symptoms in Hwa- byung patients is unclear, and further researches are needed. Trial registration Clinical Research Information Service, KCT0002379.

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Section: Discussionmentioning

confidence: 99%

Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial

Choi

Kim

Kwon

et al. 2021

Integrative Medicine Research

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“…Insomnia is commonly defined as a state of poor sleep quality caused by difficulties in sleep initiation or maintenance despite being in a proper sleep‐inducing environment (Shi et al, ). Approximately 9–15% of the general population worldwide has been reported to suffer from insomnia symptoms accompanied by daytime activity consequences (Ohayon, ).…”

Section: Pharmacologymentioning

confidence: 99%

Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

Chen

Liu

Yang

et al. 2018

Phytotherapy Research

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Central nervous system (CNS) disorders play a major impact on individual lives and place a severe strain on health care resources. Convolvulaceae is a family comprising approximately 1,600-1,700 species grouped in 55-60 genera, and many species are reported to have an effect on CNS functions. A systematic review of the literature studies was carried out to summarize available evidences on Convolvulaceae plants with CNS efficacies. This review is based on various data sources such as Google Scholar, Web of Science, Scopus, PubMed, and Wanfang Data. A total of 200 related articles were included in this review. According to the research result, 54 Convolvulaceae species are suggested to display CNS efficacies historically, and 46 species have been evaluated for their CNS efficacies. In addition, 67 compounds from 16 Convolvulaceae species are recognized to possess CNS efficacies. Despite great progress made through pharmacology and phytochemistry studies on CNS active Convolvulaceae species, more exploratory research is needed to gain a better understanding of the CNS efficacies of this plant family.

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“…Zhizichi decoction (ZZCD), comprising of Gardenia jasminoides fruit and fermented soybean, is also a traditional Chinese formula that has been widely used for depression and insomnia treatment for more than two thousand years [12]. In recent years, a combined formula of SZRD and ZZCD (Jiawei Suanzaoren Decoction, JW-SZRD) has been proven to be effective for insomnia with yin-deficiency and fire-excess syndrome [13,14]. Yin-deficiency and fire-excess syndrome usually shows palpitation, restlessness, headache, rapid pulse, hot flashes, and excessive sweating and is one of the common patterns of insomnia in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Jiawei Suanzaoren Decoction Combined with Lorazepam for Chronic Insomnia: A Parallel‐Group Randomized Controlled Trial

Song

Chen

Shao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Chronic insomnia is a major public health problem, but there are limited effective therapies. Jiawei Suanzaoren Decoction (JW-SZRD) has been used as an alternative option for treating insomnia. This study aimed to investigate the long-term efficacy and safety of JW-SZRD in combination with lorazepam for chronic insomnia. Methods. A total of 207 participants were analyzed in this study. The treatment group (TG) received JW-SZRD and lorazepam orally, and the control group (CG) received lorazepam alone. The Insomnia Severity Index (ISI), the Self-Rating Depression Scale (SDS), the Self-Rating Anxiety Scale (SAS), and the Somatic Self-rating Scale (SSS) were evaluated at baseline, weeks 4, 8, and 12. The MOS 36-item Short Form Health Survey (SF-36) was assessed at baseline and week 12. Adverse effects (AEs) were evaluated by the Treatment Emergent Symptom Scale (TESS). Results. Both TG and CG showed obvious improvements in the sleep onset latency (SOL) (P=0.001 and 0.005) and total sleep time (TST) (P=0.0001 and 0.001). However, TG was more effective than CG at weeks 8 (P=0.02 for SOL, P=0.008 for TST) and 12 (P=0.03 for SOL, P=0.04 for TST), especially in shortening SOL (Cohen’s d = 1.28). The ISI reduction rate in TG was higher than that in CG at weeks 4, 8, and 12 (P=0.008, 0.001 and 0.001). After treatment, TG had lower SAS scores (P=0.0001, 0.007), less somatic symptoms (P<0.05 or 0.01), higher SF-36 scores (P<0.05 or 0.01), better compliance (P=0.0001), and less adverse effects (P<0.05 or 0.01) than those in CG. Conclusion. The combination of JW-SZRD with lorazepam can significantly improve sleep quality with fewer AEs. It is an effective treatment and superior to lorazepam alone for chronic insomnia.

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Chinese medicines with sedative–hypnotic effects and their active components

Cited by 53 publications

References 30 publications

Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial

Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial

Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

Efficacy and Safety of Jiawei Suanzaoren Decoction Combined with Lorazepam for Chronic Insomnia: A Parallel‐Group Randomized Controlled Trial

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