Stomach specific polymeric low density microballoons as a vector for extended delivery of rabeprazole and amoxicillin for treatment of peptic ulcer

Choudhary, Sandeep; Jain, Ashay; Amin, Mohd Cairul Iqbal Mohd; Mishra, Vijay; Agrawal, Govind P.; Kesharwani, Prashant

doi:10.1016/j.colsurfb.2016.01.048

Cited by 24 publications

(9 citation statements)

References 46 publications

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“…The microballoons formed were collected, washed with distilled water, dried in hot air oven and stored in vacuum desiccators. [15][16][17] Details reported in Table 1.…”

Section: Preparation Of Microballoonsmentioning

confidence: 99%

Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: in vitro in vivo Evaluation

Marbaniang¹,

Das²,

Pal³

et al. 2019

IJPER

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Aims: Microballoons are floating particulate system comprising of a hollow core, drug being loaded within the polymeric layer. The aim of the study was to prepare microballoons containing extract of Clerodendrum colebrokianum, as bioactive agent. Methods: The microballoons were prepared by solvent diffusion technique, prepared microballoons were physico-chemically characterized (Scanning Electron Microscopy (SEM), buoyancy determination, entrapment efficiency, etc), in vitro drug release study and estimated for its in vivo antihypertensive activity by 2K1C hypertension induction method. Results: SEM confirmed the microballoons to be spherical with porous surfaces and hollow core. The developed formulation showed a buoyancy varying from 70.18%-89.90%. The entrapment efficiency of bioactives in microballoons was found between 52%-69% with a delayed release of maximum 28% in 8 hr as found from in vitro drug release study. In vivo antihypertensive studies carried out in rat model showed C. colebrookianum extract have good antihypertensive activity in both high and low dose with respect to standard propanolol. The formulations containing both doses were further found to be effectual in the treatment of hypertension because of its floating nature. Conclusion: The results suggested that optimized formulation show an effective extended release of Clerodendrum colebrokianum extract for the treatment of hypertension.

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“…The microballoons formed were collected, washed with distilled water, dried in hot air oven and stored in vacuum desiccators. [15][16][17] Details reported in Table 1.…”

Section: Preparation Of Microballoonsmentioning

confidence: 99%

Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: in vitro in vivo Evaluation

Marbaniang¹,

Das²,

Pal³

et al. 2019

IJPER

View full text Add to dashboard Cite

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“…In vitro release profile of bC was also determined using established protocol [32,33]. The amount of bC which was released from known weight of bC-NPs was calculated separately in 0.1 N HCl and PBS (pH 7.4) both containing 1% v/v tween 80 using dialysis membrane diffusion method [32,33]. In brief, weighed quantity of freeze dried bC-NPs powder was separately located inside the dialysis bag (10 kDa, Himedia, Mumbai, India).…”

Section: Characterization Of Nanoparticlesmentioning

confidence: 99%

Beta carotene-loaded zein nanoparticles to improve the biopharmaceutical attributes and to abolish the toxicity of methotrexate: a preclinical study for breast cancer

Jain

Sharma

Kushwah

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Beta carotene (βC) loaded nanoparticles of zein (βC-NPs) were developed using modified phase separation technique. βC-NPs were prepared using different zein concentration and optimized formulation was selected on the basis of micromeritics properties and entrapment efficiency. Further, βC-NPs were evaluated for in vitro release, in vitro cell-survival, cellular localization and apoptosis induced in MCF-7 cells. The combined effect of the βC and its nanoparticulate counterpart with MTX was evaluated thereafter for cytotoxicity and apoptotic activity in MCF-7 cells. In comparison to free βC, the βC-NPs demonstrated noteworthy improvement in various biopharmaceutical attributes viz C (∼2.3-folds), AUC (2.7-folds), t (∼1.5 folds) and MRT (∼1.5 folds), further indicating the remarkable increment in oral bioavailability of βC after incorporation in zein nanoparticles. The anti-tumour potential of prepared βC-NPs and effects of free βC and βC-NPs were investigated upon anticancer efficacy of methotrexate (MTX) in experimentally induced breast cancer rat model. Protective role of βC on MTX-associated hepatic toxicity in wistar rats was also determined using haematological and histopathological approaches. In a nutshell, zein nanoparticles improved the cellular uptake, cytotoxicity and exhibited enhanced oral biopharmaceutical performance of βC. This combination regimen could also be promising platform to facilitate the therapeutic benefits of anticancer agents.

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“…Floating or low-density formulations remain on the top of the gastric content (14), thus avoiding passage to the duodenum. Gas-generating platforms usually contain carbonates (15–17) and polymers to entrap the formed gas or a balloon filled with volatile liquid.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterisation of Gastroretentive Solid Dosage Form Based on Melt Foaming

et al. 2019

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Dosage forms with increased gastric residence time are promising tools to increase bioavailability of drugs with narrow absorption window. Low-density floating formulations could avoid gastric emptying; therefore, sustained drug release can be achieved. Our aim was to develop a new technology to produce low-density floating formulations by melt foaming. Excipients were selected carefully, with the criteria of low gastric irritation, melting range below 70°C and well-known use in oral drug formulations. PEG 4000, Labrasol and stearic acid type 50 were used to create metronidazole dispersion which was foamed by air on atmospheric pressure using in-house developed apparatus at 53°C. Stearic acid was necessary to improve the foamability of the molten dispersion. Additionally, it reduced matrix erosion, thus prolonging drug dissolution and preserving hardness of the moulded foam. Labrasol as a liquid solubiliser can be used to increase drug release rate and drug solubility. Based on the SEM images, metronidazole in the molten foam remained in crystalline form. MicroCT scans with the electron microscopic images revealed that the foam has a closed-cell structure, where spherical voids have smooth inner wall, they are randomly dispersed, while adjacent voids often interconnected with each other. Drug release from all compositions followed Korsmeyer-Peppas kinetic model. Erosion of the matrix was the main mechanism of the release of metronidazole. Texture analysis confirmed that stearic acid plays a key role in preserving the integrity of the matrix during dissolution in acidic buffer. The technology creates low density and solid matrix system with micronsized air-filled voids.

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Stomach specific polymeric low density microballoons as a vector for extended delivery of rabeprazole and amoxicillin for treatment of peptic ulcer

Cited by 24 publications

References 46 publications

Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: in vitro in vivo Evaluation

Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: in vitro in vivo Evaluation

Beta carotene-loaded zein nanoparticles to improve the biopharmaceutical attributes and to abolish the toxicity of methotrexate: a preclinical study for breast cancer

Development and Characterisation of Gastroretentive Solid Dosage Form Based on Melt Foaming

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