Häufigkeit und Risikofaktoren medikamentös-toxischer Leberschäden: eine umfragebasierte Studie in Apotheken

Jüngst, Christoph; Gräber, Stefan; Klähn, D; Wedemeyer, Heiner; Lammert, Frank

doi:10.1055/s-0041-104024

Cited by 4 publications

(1 citation statement)

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“… 21 In 6-week survey studies from 30 German pharmacies between 2011 and 2012, an unexpected high prevalence of DILI in pharmacy customers was reported, since, in 141 out of 1,098 patients (12.8%), elevated liver enzymes caused by suspected synthetic drugs were found. 26 Prevalence rates of DILI in Korea were significantly different from those in Germany, likely because of small sample sizes and region limitation. Additionally, describing the valid epidemiological features of specific liver injury cases requires a clear differentiation of herbal TCMs from synthetic drugs and more data from multi-center, controlled studies, as opposed to the present prevailing conditions reporting cases of DILI and HILI by TCMs together ( Table 2 ).…”

Section: Epidemiology Of Overall Liver Injury Casesmentioning

confidence: 94%

Traditional Chinese Medicine and Herb-induced Liver Injury: Comparison with Drug-induced Liver Injury

Jing¹,

Teschke²

2018

Journal of Clinical and Translational Hepatology

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Cases of suspected herb-induced liver injury (HILI) caused by herbal Traditional Chinese Medicines (TCMs) and of drug-induced liver injury (DILI) are commonly published in the scientific literature worldwide. As opposed to the multiplicity of botanical chemicals in herbal TCM products, which are often mixtures of several herbs, conventional Western drugs contain only a single synthetic chemical. It is therefore of interest to study how HILI by TCM and DILI compare with each other, and to what extent results from each liver injury type can be transferred to the other. China is among the few countries with a large population using synthetic Western drugs as well as herbal TCM. Therefore, China is well suited to studies of liver injury comparing drugs with TCM herbs. Despite some concordance, recent analyses of liver injury cases with verified causality, using the Roussel Uclaf Causality Assessment Method, revealed major differences in HILI caused by TCMs as compared to DILI with respect to the following features: HILI cases are less frequently observed as compared to DILI, have a smaller proportion of females and less unintentional rechallenge events, and present a higher rate of hepatocellular injury features. Since many results were obtained among Chinese residents who had access to and had used Western drugs and TCM herbs, such ethnic homogeneity supports the contention that the observed differences of HILI and DILI in the assessed population are well founded.

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Section: Epidemiology Of Overall Liver Injury Casesmentioning

confidence: 94%