Nifedipine Treatment for Hypertension is Associated with Enhanced Lipolytic Activity and Accelerated Clearance of Postprandial Lipemia

Grosskopf, Itamar; Shaish, Aviv; Charach, Gideon; Harats, Dror; Kamari, Yehuda

doi:10.1055/s-0035-1565180

Cited by 6 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Forthly, secondary hypertension and dyslipidemia, and genetic familial hypercholesterolemia were not excluded in this study, if any. Finally, the contents of pharmacotherapy for hypertension, which can influence the metabolism of lipids [ 44 , 45 ], the data of renal function and serum uric acid, which contribute to the development of hypertension [ 46 , 47 , 48 , 49 ], and the data of diet were also unavailable in this study. Further studies addressing these limitations are needed to warrant current results.…”

Section: Resultsmentioning

confidence: 99%

Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)

Nakajima

Igata

Higuchi

et al. 2021

JCM

View full text Add to dashboard Cite

Background: although high-density lipoprotein has cardioprotective effects, the association between serum high-density lipoprotein cholesterol (HDL-C) and hypertension is poorly understood. Therefore, we investigated whether high and low concentrations of HDL-C are associated with high blood pressure (HBP) using a large healthcare dataset. Methods: in a community-based cross-sectional study of 1,493,152 Japanese people (830,669 men and 662,483 women) aged 40–74 years who underwent a health checkup, blood pressures automatically measured at healthcare center were investigated in nine HDL-C groups (20–110 mg/dL or over). Results: crude U-shaped relationship were observed between the nine HDL-C and blood pressures in both men and women. Logistic regression analysis showed left-to-right inverted J-shaped relationships between HDL-C and odds ratios for HBP (≥140/90 mmHg and/or pharmacotherapy), with lower limits of 90–99 mg/dL in both sexes, which were unchanged after adjusting for confounding factors. However, further adjustment for body mass index and serum triglyceride concentration revealed positive linear associations between HDL-C and HBP, although blunt U-shaped associations remained in nonalcohol drinkers. Conclusion: both low and extremely high HDL-C concentrations are associated with HBP. The former association might be dependent on excess fat mass concomitant with low HDL-C, whereas the latter association may be largely dependent on frequent alcohol consumption.

show abstract

Section: Resultsmentioning

confidence: 99%

Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)

Nakajima

Igata

Higuchi

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…Nifedipine was previously shown to decrease total cholesterol, LDL-cholesterol, TG, atherogenic index and elevated HDL level in rats under ethanol and sucrose feeding (dzeufiet). Nifedipine has also significantly decreased fasting TG level and increased HDL-C in the elderly group and was shown to have favorable metabolic effects that are beyond the known enhancement of insulin sensitivity [20].…”

Section: Discussionmentioning

confidence: 97%

Effect of nifedipine and glibenclamide addition in a model of high fat diet- induced hypertension and hyperlipidemia in rabbits receiving donepezil.

Kelleni¹,

Ibrahim²,

Kamel³

2017

IJSRET

View full text Add to dashboard Cite

Geriatric individuals suffering from Alzheimer's disease are frequently co-treated for hypertension and/or diabetes. In the current research, we have explored the addition of nifedipine (1 mg/ kg), glibenclamide (0.45 mg/kg) to donepezil (0.75 mg/kg) in a rabbit model of high fat diet-induced hypertension and hyperlipidemia. Nifedipine was shown to improve hypertension, lipid profile as well as the nitro-oxidative pathway when combined with donepezil. Glibenclamide has shown an improvement regarding hypertension and nitro-oxidative pathway when compared to the high fat diet receiving group.

show abstract

“…To our astonishment, recent work in our lab found that NF caused lipid accumulation and lipotoxicity in the kidneys [22], which showed controversial effects of NF against its other cited benefits [19][20][21]. Recently, it has emerged that the UPR can be directly activated by lipid perturbation, independently of misfolded proteins [23].…”

Section: Introductionmentioning

confidence: 97%

“…NF lowered the blood pressure and inhibited the development of glomerulosclerosis to the same extent as did moxonidine (a sympatholytic agent) in spontaneously hypertensive rats [19]. In addition, NF was also reported to exhibit many hypolipidemic effects, including enhancing lipolytic activity, accelerating clearance of postprandial lipemia [20], and inhibiting lipid peroxidation [21].…”

Section: Introductionmentioning

confidence: 98%

Nifedipine Upregulates ATF6-α, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress

Peng

Chen

et al. 2020

IJMS

View full text Add to dashboard Cite

Nifedipine (NF) is reported to have many beneficial effects in antihypertensive therapy. Recently, we found that NF induced lipid accumulation in renal tubular cells. Palmitic acid-induced renal lipotoxicity was found to be partially mediated by endoplasmic reticular (ER) stress, while it can also be elicited by NF in kidney cells; we examined the induction of suspected pathways in both in vitro and in vivo models. NRK52E cells cultured in high-glucose medium were treated with NF (30 µM) for 24–48 h. ER stress-induced lipotoxicity was explored by staining with thioflavin T and Nile red, transmission electron microscopy, terminal uridine nick-end labeling, and Western blotting. ER stress was also investigated in rats with induced chronic kidney disease (CKD) fed NF for four weeks. NF induced the production of unfolded protein aggregates, resulting in ER stress, as evidenced by the upregulation of glucose-regulated protein, 78 kDa (GRP78), activating transcription factor 6α (ATF6α), C/EBP-homologous protein (CHOP), and caspases-12, -3, and -7. In vitro early apoptosis was more predominant than late apoptosis. Most importantly, ATF6α was confirmed to play a unique role in NF-induced ER stress in both models. CKD patients with hypertension should not undergo NF therapy. In cases where it is required, alleviation of ER stress should be considered to avoid further damaging the kidneys.

show abstract

Nifedipine Treatment for Hypertension is Associated with Enhanced Lipolytic Activity and Accelerated Clearance of Postprandial Lipemia

Cited by 6 publications

References 19 publications

Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)

Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)

Effect of nifedipine and glibenclamide addition in a model of high fat diet- induced hypertension and hyperlipidemia in rabbits receiving donepezil.

Nifedipine Upregulates ATF6-α, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress

Contact Info

Product

Resources

About