Assessment of Endothelial Dysfunction With Adhesion Molecules in Patients With Celiac Disease

Comba, Atakan; Çaltepe, Gönül; Yank, Keramettin; Gör, Ufuk; Yüce, Özlem; Kalayc, Ayhan Gazi

doi:10.1097/mpg.0000000000001138

Cited by 8 publications

(7 citation statements)

References 40 publications

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“…Adhesion molecules like ICAM-1, VCAM-1, and E-selectin are expressed on the membrane surface of endothelial cells and mediate adhesion of various leukocyte types, such as lymphocytes and monocytes, to the vascular endothelium 40 , 41 . Therefore, high levels of adhesion molecules have been considered to be an early indicator of endothelial dysfunction 42 . In the present study, HG obviously increased the expression of these three molecules ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells

et al. 2019

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Endothelial dysfunction is closely associated with diabetic complications. Icariin, a flavonoid glycoside isolated from the Epimedium plant species, exhibits antidiabetic properties. However, its impact on endothelial function remains poorly understood, particularly under hyperglycemia. In this study, we investigated the potential protective effect of icariin on high glucose-induced detrimental effects on vascular endothelial cells. Human umbilical venous endothelial cells were incubated in media containing 5.5 mM glucose (normal glucose) or 25 mM glucose (high glucose) in the presence or absence of 50 µM icariin for 72 h. We found that high glucose markedly induced cell apoptosis, enhanced reactive oxygen species generation, and elevated expression levels of inflammatory factors and cell adhesion molecules, which were greatly subdued by icariin supplementation. In conclusion, icariin exerted a beneficial effect on high glucose-induced endothelial dysfunction. This new finding provides a promising strategy for future treatment of diabetic vascular complications.

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Section: Discussionmentioning

confidence: 99%

Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells

et al. 2019

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“…The present evidence of altered endothelial function is in line with clinical studies that showed impaired flow-mediated dilation in CeD patients compared to healthy controls [ 34 ]. In this vein, other studies showed elevated levels of soluble vascular adhesion molecule-1, soluble intercellular adhesion molecule-1 and soluble endothelial selectin [ 35 ] and plasmatic oxidative stress [ 36 ] in CeD subjects.…”

Section: Discussionmentioning

confidence: 88%

Vascular dysfunction and arterial hypertension in experimental celiac disease are mediated by gut-derived inflammation and oxidative stress

Keppeler,

Pesi,

Lange

et al. 2024

Redox Biology

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“…On the other hand, the coagulopathy or thrombotic condition that can be seen in celiac disease is attributed to causes such as chronic inflammation, endothelial damage, the presence of phospholipid Ig A autoantibodies, and hyperhomocysteinemia due to protein loss in the intestinal wall or related to folate deficiency. [19][20][21] In children, while thrombocytopenia and coagulopathy are rarely seen in the course of celiac disease, this association has been described for the first time in the celiac crisis. This case highlights that a celiac patient may present with a severe illness like sepsis and may be associated with thrombocytopenia and coagulopathy in the crisis.…”

Section: Case Reportmentioning

confidence: 98%

Celiac crisis with thrombocytopenia and coagulopathy in a child

Mazman¹,

Dereci²,

Hızlı³

et al. 2022

Turk J Pediatr

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Background. Celiac disease rarely presents with edema, hypoalbuminemia, acute metabolic deterioration, and electrolyte imbalances. This life-threatening condition is defined as a celiac crisis and may mimic disorders with metabolic derangement and sepsis. The crisis may present at onset or develop in celiac disease patients with poor compliance to a gluten-free diet. The fluid resuscitation and replacement of electrolyte deficits are life-saving modalities. Case. A 14-month-old girl was admitted with fever, lethargy, severe dehydration, edema, hypotension, and commenced sepsis therapy. However, the patient had a growth delay and loss of weight with diarrhea and delayed motor skills. On admission, laboratory evaluation showed anemia, coagulopathy, hypoalbuminemia, electrolyte disturbances, and metabolic acidosis and developed thrombocytopenia during follow-up. The celiac serological tests and upper gastrointestinal endoscopic duodenal mucosa appearance, and duodenum histopathology findings suggested celiac disease. Conclusions. This case highlights that a celiac patient may present with a severe illness like sepsis and may be associated with cytopenia and coagulopathy in the celiac crisis.

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Assessment of Endothelial Dysfunction With Adhesion Molecules in Patients With Celiac Disease

Abstract: These results show that serum adhesion molecule levels are higher in patients with CD. Some of the risks associated with endothelial dysfunction may be related to CD and these risks can be reduced with an appropriate and fully controlled diet.

Cited by 8 publications

References 40 publications

Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells

Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells

Vascular dysfunction and arterial hypertension in experimental celiac disease are mediated by gut-derived inflammation and oxidative stress

Celiac crisis with thrombocytopenia and coagulopathy in a child

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