Skin Patterns Associated with Upper Airway Infantile Haemangiomas: A Retrospective Multicentre Study

Uthurriague, C.; Boccara, O.; Catteau, Beno it; Fayoux, P.; Léauté‐Labrèze, Christine; Chiavérini, C.; Maruani, Annabel; Pondaven-Letourmy, Soizick; Alaidarous, Abdulqader; Puzenat, E.; Hubiche, T.; Mallet, S.; Dreyfus, I.; Mazereeuw‐Hautier, J.

doi:10.2340/00015555-2357

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…9,[11][12][13] IHs with life-threatening complications include obstructive airway hemangiomas such as subglottic hemangiomas (Fig. 1), [35][36][37][38] hepatic IHs associated with high-output congestive heart failure and hypothyroidism, 39,40) and profuse bleeding from ulcerated IHs. 11) Subglottic hemangiomas are diagnosed at mean age of 4 months, and patients present with progressive biphasic stridor, a barking cough, and dyspnea, and they may be misdiagnosed with congenital laryngeal stridor or infectious croup.…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Update on infantile hemangioma

Jung

2021

Clin Exp Pediatr

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The International Society for the Study of Vascular Anomalies classifies vascular anomalies into vascular tumors and vascular malformations. Vascular tumors are neoplasms of endothelial cells, among which infantile hemangiomas (IHs) are the most common, occurring in 5-10% of infants. Glucose transporter-1 protein expression in IHs differs from that of other vascular tumors or vascular malformations. IHs are not present at birth but are usually diagnosed at 1 week to 1 month of age, rapidly proliferate between 1 and 3 months of age, mostly complete proliferation by 5 months of age, and then slowly involute to the adipose or fibrous tissue. Approximately 10% of IH cases require early treatment. The 2019 American Academy of Pediatrics clinical practice guideline for the management of IHs recommends that primary care clinicians frequently monitor infants with IHs, educate the parents about the clinical course, and refer infants with high-risk IH to IH specialists ideally at 1 month of age.High-risk IHs include those with life-threatening complications, functional impairment, ulceration, associated structural anomalies, or disfigurement. In Korea, IHs are usually treated by pediatric hematology-oncologists with the cooperation of pediatric cardiologists, radiologists, dermatologists, and plastic surgeons. Oral propranolol, a non-selective betaadrenergic antagonist, is the first-line treatment for IHs at a dosage of 2-3 mg/kg/day divided into two daily doses maintained for at least 6 months and often continuing until 12 months of age. Topical timolol maleate solution, a topical non-selective beta-blocker, may be used for small superficial type IHs at a dosage of 1-2 drops of 0.5% gel-forming ophthalmic solution applied twice daily. Pulse-dye laser therapy or surgery is useful for the treatment of residual skin changes after IH involution.

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Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Update on infantile hemangioma

Jung

2021

Clin Exp Pediatr

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“…Airway IHs cause functional damage due to upper airway obstruction leading to respiratory insufficiency and life-threatening complications in the absence of treatment. They are frequently associated with a cutaneous distribution in a known fashion ( 3 ). Although, as seen in our case series and in the literature, they can present without cutaneous involvement.…”

Section: Discussionmentioning

confidence: 99%

“…However, they can also develop in children in the absence of cutaneous hemangiomas. Moreover, recent studies demonstrated that AIHs might be associated with more limited skin patterns, as well as with posterior and lateral neck involvement ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Management of Upper Airway Infantile Hemangiomas: Experience of One Italian Multidisciplinary Center

et al. 2021

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Airway infantile hemangiomas (IHs) can represent a life-threatening condition since the first months of life. They may be isolated or associated to cutaneous IHs, and/or part of PHACES syndrome. Diagnosis, staging, and indication to treatment are not standardized yet despite the presence in the literature of previous case series and reviews. The diagnosis might be misleading, especially in the absence of cutaneous lesions. Airway endoscopy is the gold standard both for diagnosis and follow-up since it allows evaluation of precise localization and entity of obstruction and/or stricture. Proliferation of IH in the infant airways manifests frequently with stridor and treatment is required as soon as possible to prevent further complications. The first line of therapy is oral propranolol, but duration of treatment is not yet well-defined. All considered, we report the experience of our multidisciplinary center from 2009 to date, on 36 patients affected by airway IHs, and successfully treated with oral propranolol. Thus, the authors propose their experience for the management of airway IHs, specifically early diagnosis, when to perform endoscopy, how to interpret its findings, and when to stop the treatment.

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“…19,20 Segmental IH located in the beard area often involves the pharynx and larynx, thus greatly increasing the risk of airway obstruction. 3,21 As a high-risk type of IH, segmental IH has a high possibility of inducing structural abnormalities, such as PHACE syndrome and LUMBAR syndrome. 4,8,22 In addition, segmental IH may be associated with a higher risk of concomitant hepatic hemangioma than nonsegmental IH.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Segmental Infantile Hemangioma: A Prospective Study

Qiu¹,

Yang²,

Dai³

et al. 2021

TCRM

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Background Infantile hemangioma (IH) is the most common benign tumor in children. However, few studies have reported the clinical features of segmental IH. We aimed to determine the clinical characteristics of segmental IH and to identify features that may aid clinicians in managing segmental IH. Methods In the cross-sectional prospective study approved by the Ethics Committee of the hospital, children diagnosed with IH were recruited, and information including patient demographics, IH morphology and anatomical location, complications and treatments were recorded and analyzed. Results In total, 153 patients with segmental IH and 1375 patients with nonsegmental IH were enrolled in this study. The average age on the day of the first visit in patients with segmental IH was 3.63±3.23 months. In 69 patients (45.10%), segmental IH was diagnosed at birth. Most segmental IHs (49.67%) occurred in the limbs, while only 22.04% of nonsegmental IHs occurred in the extremities ( P <0.001). Thirteen patients (8.50%) with segmental IH had ulceration. Compared with patients with nonsegmental IHs, patients with segmental IHs were more likely to be treated with oral drugs ( P <0.001). Conclusion Segmental IHs mainly occur in the extremities and are frequently diagnosed at birth. Segmental IHs are usually accompanied by ulceration, which are more commonly seen in the neck and perineal/perianal/genital areas than nonsegmental IHs. Oral propranolol is prescribed more often in patients with segmental IH than in those with nonsegmental IH.

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Skin Patterns Associated with Upper Airway Infantile Haemangiomas: A Retrospective Multicentre Study

Cited by 8 publications

References 21 publications

Update on infantile hemangioma

Update on infantile hemangioma

Management of Upper Airway Infantile Hemangiomas: Experience of One Italian Multidisciplinary Center

Clinical Features of Segmental Infantile Hemangioma: A Prospective Study

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