Growth curves for Turkish Girls with Turner Syndrome: Results of the Turkish Turner Syndrome Study Group

Darendelıler, Feyza; Yeşilkaya, Ediz; Bereket, Abdullah; Baş, Firdevs; Bundak, Rüveyde; Sarı, Erkan; Aydın, Banu Küçükemre; Darcan, Şükran; Dündar, Bumin Nuri; Buyukınan, Muammer; Kara, Cengiz; Mazıcıoğlu, M. Mümtaz; Adal, Erdal; Akıncı, Ayşehan; Atabek, Mehmet Emre; Demirel, Fatma; Çelik, Nurullah; Özkan, Behzat; Özhan, Bayram; Orbak, Zerrin; Ersoy, Betül; Doğan, Murat; Ataş, Ali; Turan, Serap; Gökşen, Damla; Tarım, Ömer; Yüksel, Bilgin; Ercan, Oya; Hatun, Şükrü; Şimşek, Enver; Ökten, Ayşenur; Abacı, Ayhan; Doneray, Hakan; Özbek, Mehmet Nuri; Keskın, Mehmet; Önal, Hasan; Akyürek, Nesibe; Bulan, Kezban; Tepe, Derya; Emeksiz, Hamdi Cihan; Demır, Kadir; Kızılay, Deniz Özalp; Topaloğlu, Ali Kemal; Eren, Erdal; Özen, Samim; Demirbilek, Hüseyin; Abali, Saygın; Akın, Leyla; Eklioğlu, Beray Selver; Kaba, Sultan; Anık, Ahmet; Baş, Serpil; Ünüvar, Tolga; Sağlam, Halil; Bolu, Semih; Özgen, İlker Tolga; Doğan, Durmuş; Çakır, Esra Deniz Papatya; Şen, Yaşar; Andıran, Nesibe; Çizmecioğlu, Filiz Mine; Evliyaoğlu, Olcay; Karagüzel, Gülay; Pirgon, Özgür; Çatlı, Gönül; Can, Hatice Dilek; Gürbüz, Fatih; Binay, Çiğdem; Baş, Veysel Nijat; Sağlam, Celal; Gül, Davut; Polat, Adem; Açıkel, Cengizhan; Cınaz, Peyami

doi:10.4274/jcrpe.2023

Cited by 5 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To visualize overall growth in girls with TS, median standard deviation scores (SDSs) of height, weight, body mass index (BMI), and weight for height (WFH) of Japanese girls with TS for Japanese normal population are shown in Figure 1A (height, weight, and BMI) and Figure 1B (WFH) (9,27). The population of Japan is generally considered ethnically homogeneous and the growth patterns of girls with TS are similar among various ethnicities, judging from reported TS-specific growth charts (8,9,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Therefore, we think that the visualization could help our understanding of overall growth in girls with TS not only in Japan but also in other countries.…”

Section: Overall Growth In Girls With Tsmentioning

confidence: 99%

“…At present, disease-specific growth charts are available for several syndromes, such as TS, Prader-Willi syndrome, Down syndrome, Williams syndrome, and Noonan syndrome (8)(9)(10)(11)(12)(13)(14). TS-specific growth charts have been constructed in many countries worldwide (8,9,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) and are widely used for following up patients and evaluating the effect of growthpromoting treatment. In addition, TS-specific growth charts have had a role in revealing the overall growth patterns of girls with TS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Growth in girls with Turner syndrome

Isojima

Yokoya²

2023

Front. Endocrinol.

View full text Add to dashboard Cite

Turner syndrome (TS) is a chromosomal disorder affecting females characterized by short stature and gonadal dysgenesis. Untreated girls with TS reportedly are approximately 20-cm shorter than normal girls within their respective populations. The growth patterns of girls with TS also differ from those of the general population. They are born a little smaller than the normal population possibly due to a mild developmental delay in the uterus. After birth, their growth velocity declines sharply until 2 years of age, then continues to decline gradually until the pubertal age of normal children and then drops drastically around the pubertal period of normal children because of the lack of a pubertal spurt. After puberty, their growth velocity increases a little because of the lack of epiphyseal closure. A secular trend in height growth has been observed in girls with TS so growth in excess of the secular trend should be used wherever available in evaluating the growth in these girls. Growth hormone (GH) has been used to accelerate growth and is known to increase adult height. Estrogen replacement treatment is also necessary for most girls with TS because of hypergonadotropic hypogonadism. Therefore, both GH therapy and estrogen replacement treatment are essential in girls with TS. An optimal treatment should be determined considering both GH treatment and age-appropriate induction of puberty. In this review, we discuss the growth in girls with TS, including overall growth, pubertal growth, the secular trend, growth-promoting treatment, and sex hormone replacement treatment.

show abstract

Section: Overall Growth In Girls With Tsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Growth in girls with Turner syndrome

Isojima

Yokoya²

2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…In a recent multicenter study, the growth curves of Turkish children with TS were created [ 3 ]. According to these data, the final height in TS without treatment is 141.9 ± 6.9 cm [ 4 ], slightly lower than the European patients [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Body proportions in patients with Turner syndrome on growth hormone treatment

AL¹,

ŞÜKÜR²,

ÖZTURAN³

et al. 2023

Turkish Journal of Medical Sciences

View full text Add to dashboard Cite

Background In this cross-sectional study, we aimed to evaluate auxological measurements and detailed body proportions of recombinant human growth hormone (GH)-treated patients with Turner syndrome (TS) and compare them with a group of healthy females. Materials and methods We evaluated 42 patients with TS who received GH treatment and 20 healthy controls. Anthropometric measurements were taken and target height, body mass index (BMI), arm span-height difference, extremity-to-trunk ratio, and Manouvrier’s skelic index were calculated. Results The median (min–max) age of the patients at the time of evaluation was 13.6 (4.3–20.7) years, and the control group was 12.9 (3.8–23.7) years. Height, sitting height, and arm span of TS patients were significantly lower than those of the control group. Sitting height/height ratio (SHR) was in normal ranges in both groups and BMI was significantly higher in TS patients when compared to the control group. According to Manouvrier’s skelic index, TS patients had shorter legs than the control group (p = 0.001). The extremity-trunk ratio was significantly decreased in TS patients compared to healthy controls (p < 0.001). There was no significant difference between the karyotype groups in terms of these indexes. Conclusion TS patients had short stature, increased BMI and waist circumference, normal head circumference, and decreased extremity-trunk ratio. Sitting height and leg length were short; however, the SHR standard deviation score (SDS) was in the normal range. Despite being treated with GH, TS patients had disproportionate short stature. The disproportion in TS patients was similar to short-stature homeobox-containing gene (SHOX) deficiency, which is considered to be SHOX haploinsufficiency in the etiopathogenesis of short stature.

show abstract

Karyotype classification, clinical manifestations and outcome in 124 Turner syndrome patients in China

2019

Annales d'Endocrinologie

View full text Add to dashboard Cite

Growth curves for Turkish Girls with Turner Syndrome: Results of the Turkish Turner Syndrome Study Group

Cited by 5 publications

References 29 publications

Growth in girls with Turner syndrome

Growth in girls with Turner syndrome

Body proportions in patients with Turner syndrome on growth hormone treatment

Karyotype classification, clinical manifestations and outcome in 124 Turner syndrome patients in China

Contact Info

Product

Resources

About