Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Kim, Jong Hoon; Choi, Young Joon; Lee, Byung Ha; Song, Mi Jin; Ban, Chae Yeon; Kim, Jihye; Park, Junsik; Kim, Soo Chan; Kim, Tae Kyun; Park, Su–Hyung; Kim, Hyoung‐Pyo; Sung, Young Chul; Shin, Eui‐Cheol

doi:10.1016/j.jaci.2015.11.021

Cited by 66 publications

(61 citation statements)

References 33 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both γδ T cells and CD4 + Th17 cells are IL-17-producing effector cells that drive human psoriasis and the IMQ-induced model of psoriasiform inflammation 10,12–14 . To investigate the contribution of γδ T cells and CD4 + Th17 cells during the development of psoriasiform inflammation in the Vsir −/− mice, we first examined their cell number in the ear and ear-draining LN.…”

Section: Resultsmentioning

confidence: 99%

Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis

Xu²,

Yuan

et al. 2017

Sci Rep

View full text Add to dashboard Cite

V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. Vsir−/− mice developed loss of peripheral tolerance and multi-organ chronic inflammatory phenotypes. Vsir−/− CD4+ and CD8+ T cells were hyper-responsive towards self- and foreign antigens. Whether or not VISTA regulates innate immunity is unknown. Using a murine model of psoriasis induced by TLR7 agonist imiquimod (IMQ), we show that VISTA deficiency exacerbated psoriasiform inflammation. Enhanced TLR7 signaling in Vsir−/− dendritic cells (DCs) led to the hyper-activation of Erk1/2 and Jnk1/2, and augmented the production of IL-23. IL-23, in turn, promoted the expression of IL-17A in both TCRγδ+ T cells and CD4+ Th17 cells. Furthermore, VISTA regulates the peripheral homeostasis of CD27− γδ T cells and their activation upon TCR-mediated or cytokine-mediated stimulation. IL-17A-producing CD27− γδ T cells were expanded in the Vsir−/− mice and amplified the inflammatory cascade. In conclusion, this study has demonstrated that VISTA critically regulates the inflammatory responses mediated by DCs and IL-17-producing TCRγδ+ and CD4+ Th17 T cells following TLR7 stimulation. Our finding provides a rationale for therapeutically enhancing VISTA-mediated pathways to benefit the treatment of autoimmune and inflammatory disorders.

show abstract

Section: Resultsmentioning

confidence: 99%

Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis

Xu²,

Yuan

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…21 The same authors observed similar results in the skin of psoriatic patients in whom immunofluorescent staining also revealed an overexpression of PD-1 on IL-17A-producing T cells.…”

mentioning

confidence: 54%

The expression of selected molecular markers of immune tolerance in psoriatic patients

Bartosińska¹,

Purkot²,

Kowal³

et al. 2018

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. Psoriasis is a chronic autoinflammatory disease whose underlying molecular mechanisms remain unclear. The disease is mediated by the cells and molecules of both the innate and adaptive immune systems. Some T cell surface molecules, including neuropilin-1 (NRP1), programmed death 1 (PD-1) and the human leukocyte antigen G (HLA-G), are known to play a role in the maintenance of immune tolerance.

show abstract

“…It has been shown to contribute to the accumulation of IL-6 and GCSF as well as cardiotoxicity induced by DOX. [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Eleutheroside E inhibits doxorubicin-induced inflammation and apoptosis in rat cardiomyocytes by modulating activation of NF-κB pathway

Zheng¹,

Li²,

Sun³

et al. 2017

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To identify the effects of eleutheroside E (EE) on apoptosis and inflammation induced by doxorubicin (DOX) in H9c2 cells and to investigate the underlying mechanisms. Methods: The effect of EE on H9c2 cell viability was determined using Cell Counting Kit-8 (CCK8). EE effect on DOX-induced apoptosis and inflammation in H9c2 cells was studied by comparison between cells treated with DOX alone and DOX+EE; the relationship between EE effects and NF-κB signaling pathway was evaluated by the addition of NF-κB inhibitor PDTC. Cell apoptosis was examined by flow EE pretreatment (10, 50 and 80 μM) to 11.51 ± 1.25, 40.2 ± 5.17 and 52.97 ± 6.74

show abstract

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells

Abstract: PD-1 is overexpressed in IL-17A-producing T cells in both imiquimod-treated mice and patients with psoriasis. Moreover, recombinant PD-L1-Fc alleviates psoriatic inflammation in imiquimod-treated mice.

Cited by 66 publications

References 33 publications

Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis

Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis

The expression of selected molecular markers of immune tolerance in psoriatic patients

Eleutheroside E inhibits doxorubicin-induced inflammation and apoptosis in rat cardiomyocytes by modulating activation of NF-κB pathway

Contact Info

Product

Resources

About