The Incidence of End-Stage Renal Disease in the Diabetic (Compared to the Non-Diabetic) Population: A Systematic Review

Abstract

End-stage renal disease (ESRD) in diabetes is a life threatening complication resulting in a poor prognosis for patients as well as high medical costs. The aims of this systematic review were (1) to evaluate the incidence of ESRD due to all causes and due to diabetic nephropathy in the diabetic population and differences between incidences of ESRD with respect to sex, ethnicity, age and regions, (2) to compare incidence rates in the diabetic and non-diabetic population, and (3) to investigate time trends. The systematic review was conducted according to the PRISMA group guidelines by performing systematic literature searches in the biomedical databases until January 3rd 2015; thirty-two studies were included. Among patients with incident type 1 diabetes the 30-year cumulative incidence ranged from 3.3% to 7.8%. Among patients with prevalent diabetes, incidence rates of ESRD due to all causes ranged from 132.0 to 167.0 per 100,000 person-years, whereas incidence rates of ESRD due to diabetic nephropathy varied from 38.4 to 804.0 per 100,000 person-years. The incidence of ESRD in the diabetic population was higher compared to the non-diabetic population, and relative risks varied from 6.2 in the white population to 62.0 among Native Americans. The results regarding time trends were inconsistent. The review conducted demonstrates the considerable variation of incidences of ESRD among the diabetic population. Consistent findings included an excess risk when comparing the diabetic to the non-diabetic population and ethnic differences. We recommend that newly designed studies should use standardized methods for the determination of ESRD and population at risk.

Macro and Micro-Vascular Complications and their Risk Factors in Diabetes Mellitus Patients of Southern Punjab, Pakistan

“…An increase in incidence rate of end stage renal disease (ESRD) due to diabetic nephropathy (DN) was expected correspondingly severe individual and social consequences. [8] Diabetic retinopathy (DR) is the principal cause of blindness in diabetes patients and its cases are mounting gradually. [9] Long term complications of diabetes include peripheral neuropathy (PN) and peripheral vascular disease (PVD).…”

ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions

“…Diabetic nephropathy is a very concerning microvascular complication of diabetes mellitus, whose global incidence is on the rise, rapidly12. It has been established that diabetic nephropathy eventually progresses into end-stage renal disease and is the leading cause for renal replacement therapy in developed countries3.…”

Risk Differences between Elderly Men and Women toward Doctor-Diagnosed Diabetes Mellitus in Urban Areas in Indonesia: 2013 National Basic Health Research Data

“…Recently, it has been shown that among older patients with type 2 diabetes and endstage renal disease (ESRD), mortality rates were higher among women than men. 21 Finding also showed that education (level of schooling) was not a significant predictor among urban women; while in other countries education is a highly significant predictors of quality of life among women with type 2 diabetes as compared to men. 19 This means that the people's knowledge about type 2 diabetes needs to be enhanced through public health education.…”