Juçara pulp supplementation improves glucose tolerance in mice

Abstract

BackgroundThe consumption of hyperlipidic and hypercaloric diet is considered a major factor to promote obesity and the consumption of food with antioxidant properties, like Juçara (Euterpe edulis Mart), could be a tool to prevent the deleterious effect of high white adipose deposition. The aim of the present study was to evaluate the effect of administration of juçara pulp in mice fed a high-fat, high-calorie diet on glucose tolerance and adipose tissue inflammatory status.MethodsMice were distributed into the following groups: control diet; control diet plus 0.5 % of juçara; control diet plus 2 % of juçara; hypercaloric and hyperlipidic diet; hypercaloric and hyperlipidic diet plus 0.5 % of juçara and hypercaloric and hyperlipidic diet plus 2 % of juçara. Treatments started when mice were 8 weeks old and carried on for a total period of 10 weeks. The serum glucose, triacylglycerol, total cholesterol, insulin, adiponectin, lipopolysaccharides and free fatty acids concentrations were measured. Oral glucose tolerance test was performed. TNF-α, IL-6, and IL-10 protein level were determined by ELISA on mesenteric and epididymal white adipose tissues. Determination of catalase activity was realized in the same tissues. Data were analysed using one-way analysis of variance and post hoc analysis was performed with the Tukey’s test.ResultsThe addition of 0.5 % juçara improved glycemic response in animals that consumed normocaloric as well as hypercaloric and hyperlipidic diets (HC). Supplementation with 0.5 and 2 % did not change the body composition of animals that received the HC diet; however, the animals fed the normocaloric diet with 2 % juçara gained body mass. An intake of 2 % juçara in the HC diet promoted a reduction of catalase activity and IL-10 level in epididymal adipose tissue.ConclusionsThese results suggest that with the administration of 0.5 % juçara, the beneficial effects of polyphenols overcome the deleterious effects of macronutrient composition of juçara, whereas with the administration of 2 % juçara promotes damage by the composition of the fruit and overshadows the beneficial effects of polyphenols on glucose metabolism. On the other hand, higher juçara supplementation improves the inflammatory status targeted by the HC diet.

Chia (Salvia hispanica L.) flour promotes beneficial effects on adipose tissue but not on glycaemic profile of diet‐induced obesity in mice

“…The elevation of these inflammatory adipokines may contribute to the development of insulin resistance and metabolic syndrome [25]. Although results showed no significant difference in inflammatory cytokines between the control and hypercaloric groups of the present study, the hypercaloric diet given to the H group had been able to promote inflammation of adipose tissue in a previous study by our research group [14]. The study conducted by Cano et al in 2009 [26] may explain this unexpected result of our study, since authors had verified that a high-fat diet is able to disrupt the daily patterns of the cytokines adiponectin, IL-6 and TNF-a.…”

“…Although the removal of tissue samples from the mice in the present study had been performed concurrently with the study by Oyama et al in 2016 , it is possible that we performed the removal at a time when no statistical difference could have been observed between the groups that received the control and high‐fat diets, which may have been due to hormonal alteration of the circadian cycle caused by the high‐fat diet. Therefore, we cannot infer that the chia caused anti‐inflammatory action in the epididymal adipose tissue.…”

Lactobacillus fermentation of jussara pulp leads to the enzymatic conversion of anthocyanins increasing antioxidant activity

“…Studies in our group showed that jussara supplementation during pregnancy and lactation modulates gene and protein expression of inflammation biomarkers and improves colonic expression of ZO-1 in offspring (Morais et al, 2016(Morais et al, , 2014. Additionally, jussara supplementation improves glucose tolerance in mice (Oyama et al, 2016). The high concentration of phenolic compounds, especially anthocyanins, appears to be responsible for these biological effects.…”

Development and Characterization of Electrospun Nanostructures Using Polyethylene Oxide: Potential Means for Incorporation of Bioactive Compounds

“…Jussara has been extensively considered as a superfruit and highlights the potentialities related to the Brazilian biodiversity as a source of high-value products. Studies in our group showed that jussara, besides the colorant power provided by the anthocyanins, is accounted for in several beneficial results from a perspective of health and well-being [27,[30][31][32]. Jussara pulp has been recognized as a superfood due to its composition, mainly, for the high concentration of anthocyanins and other phenolic compounds; in fact, these bioactive compounds are considered an attractive source of pigments and also means to ward off several diseases [27,33,34].…”