Stimulus-dependent amygdala involvement in affective theory of mind generation

Schmitgen, Mike M.; Walter, Henrik; Drost, Sarah; Rückl, Sarah; Schnell, Knut

doi:10.1016/j.neuroimage.2016.01.029

Cited by 19 publications

(18 citation statements)

References 40 publications

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“…Recent studies, including a review article, have reported the involvement of both the right and left hemispheres in mentalizing (Gallagher and Frith, 2003 ; Völlm et al, 2006 ; Carrington and Bailey, 2009 ; Van Overwalle, 2009 ; Kumfor and Piguet, 2012 ). Notably and in line with alternative findings, a rightward lateralization in emotional processing has been suggested by a number of studies (Schwartz et al, 1975 ; Borod et al, 1992 , 1998 ; Fournier et al, 2008 ; Kumfor and Piguet, 2012 ; Yeh and Tsai, 2014 ; Schmitgen et al, 2016 ). Fusar-Poli et al ( 2009 ) performed a meta-analysis of samples from 1600 healthy subjects and reported a rightward lateralization in emotional face processing.…”

Section: Introductionsupporting

confidence: 63%

Neural Networks Mediating High-Level Mentalizing in Patients With Right Cerebral Hemispheric Gliomas

Nakajima

Kinoshita

Okita

et al. 2018

Front. Behav. Neurosci.

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Mentalizing is the ability to understand others’ mental state through external cues. It consists of two networks, namely low-level and high-level metalizing. Although it is an essential function in our daily social life, surgical resection of right cerebral hemisphere disturbs mentalizing processing with high possibility. In the past, little was known about the white matter related to high-level mentalizing, and the conservation of high-level mentalizing during surgery has not been a focus of attention. Therefore, the main purpose of this study was to examine the neural networks underlying high-level mentalizing and then, secondarily, investigate the usefulness of awake surgery in preserving the mentalizing network. A total of 20 patients with glioma localized in the right hemisphere who underwent awake surgery participated in this study. All patients were assigned to two groups: with or without intraoperative assessment of high-level mentalizing. Their high-level mentalizing abilities were assessed before surgery and 1 week and 3 months after surgery. At 3 months after surgery, only patients who received the intraoperative high-level mentalizing test showed the same score as normal healthy volunteers. The tract-based lesion symptom analysis was performed to confirm the severity of damage of associated fibers and high-level mentalizing accuracy. This analysis revealed the superior longitudinal fascicles (SLF) III and fronto-striatal tract (FST) to be associated with high-level mentalizing processing. Moreover, the voxel-based lesion symptom analysis demonstrated that resection of orbito-frontal cortex (OFC) causes persistent mentalizing dysfunction. Our study indicates that damage of the OFC and structural connectivity of the SLF and FST causes the disorder of mentalizing after surgery, and assessing high-level mentalizing during surgery may be useful to preserve these pathways.

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Section: Introductionsupporting

confidence: 63%

Neural Networks Mediating High-Level Mentalizing in Patients With Right Cerebral Hemispheric Gliomas

Nakajima

Kinoshita

Okita

et al. 2018

Front. Behav. Neurosci.

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“…Activation of pars opercularis and premotor regions is consistently observed in affective ToM paradigms involving pictures or videos of dyadic interactions without much context, thereby imposing greater demands on the observer's capacity for simulation ( Keysers and Gazzola, 2007 ; Molenberghs et al , 2016 ). On the other hand, affective ToM tasks requiring integration of static facial emotion cues with story-based, contextual cues likely impose less demand on simulation mechanisms, and are more closely tied to SN regions that support detection and integration of these salient emotion cues into affective ToM judgments ( Schmitgen et al , 2016 ). In line with this evidence, our results suggest that ToM is associated with various neural routes, which may depend on the extent to which a task imposes demands on simulation mechanisms (i.e.…”

Section: Discussionmentioning

confidence: 99%

Uncovering the neuroanatomical correlates of cognitive, affective and conative theory of mind in paediatric traumatic brain injury: a neural systems perspective

Ryan

Catroppa

Beare

et al. 2017

Social Cognitive and Affective Neuroscience

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Deficits in theory of mind (ToM) are common after neurological insult acquired in the first and second decade of life, however the contribution of large-scale neural networks to ToM deficits in children with brain injury is unclear. Using paediatric traumatic brain injury (TBI) as a model, this study investigated the sub-acute effect of paediatric traumatic brain injury on grey-matter volume of three large-scale, domain-general brain networks (the Default Mode Network, DMN; the Central Executive Network, CEN; and the Salience Network, SN), as well as two domain-specific neural networks implicated in social-affective processes (the Cerebro-Cerebellar Mentalizing Network, CCMN and the Mirror Neuron/Empathy Network, MNEN). We also evaluated prospective structure–function relationships between these large-scale neural networks and cognitive, affective and conative ToM. 3D T1- weighted magnetic resonance imaging sequences were acquired sub-acutely in 137 children [TBI: n = 103; typically developing (TD) children: n = 34]. All children were assessed on measures of ToM at 24-months post-injury. Children with severe TBI showed sub-acute volumetric reductions in the CCMN, SN, MNEN, CEN and DMN, as well as reduced grey-matter volumes of several hub regions of these neural networks. Volumetric reductions in the CCMN and several of its hub regions, including the cerebellum, predicted poorer cognitive ToM. In contrast, poorer affective and conative ToM were predicted by volumetric reductions in the SN and MNEN, respectively. Overall, results suggest that cognitive, affective and conative ToM may be prospectively predicted by individual differences in structure of different neural systems—the CCMN, SN and MNEN, respectively. The prospective relationship between cerebellar volume and cognitive ToM outcomes is a novel finding in our paediatric brain injury sample and suggests that the cerebellum may play a role in the neural networks important for ToM. These findings are discussed in relation to neurocognitive models of ToM. We conclude that detection of sub-acute volumetric abnormalities of large-scale neural networks and their hub regions may aid in the early identification of children at risk for chronic social-cognitive impairment.

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“…It is thought that the developed activation of the FG, and in particular the FFA, in response to faces corresponds to an increased necessity to sensitively processing facial information, leading adolescents and adults to become face reading “experts” ( Gauthier et al, 2000b ). This is significant regarding ToM, as a developed expertise in facial recognition allows for nuanced interpretations when reading emotional expressions ( Schmitgen et al, 2016 ). Individuals with ASD have been shown to demonstrate hypoactivation in the FG and FFA when looking at specifically human faces ( Dawson et al, 2005 ; Humphreys et al, 2008 ; Pierce and Redcay, 2008 ).…”

Section: Fusiform Face Area (Ffa)mentioning

confidence: 99%

Seeing More Than Human: Autism and Anthropomorphic Theory of Mind

Atherton

Cross

2018

Front. Psychol.

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Theory of mind (ToM) is defined as the process of taking another’s perspective. Anthropomorphism can be seen as the extension of ToM to non-human entities. This review examines the literature concerning ToM and anthropomorphism in relation to individuals with Autism Spectrum Disorder (ASD), specifically addressing the questions of how and why those on the spectrum both show an increased interest for anthropomorphism and may even show improved ToM abilities when judging the mental states of anthropomorphic characters. This review highlights that while individuals with ASD traditionally show deficits on a wide range of ToM tests, such as recognizing facial emotions, such ToM deficits may be ameliorated if the stimuli presented is cartoon or animal-like rather than in human form. Individuals with ASD show a greater interest in anthropomorphic characters and process the features of these characters using methods typically reserved for human stimuli. Personal accounts of individuals with ASD also suggest they may identify more closely with animals than other humans. It is shown how the social motivations hypothesized to underlie the anthropomorphizing of non-human targets may lead those on the spectrum to seek social connections and therefore gain ToM experience and expertise amongst unlikely sources.

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Stimulus-dependent amygdala involvement in affective theory of mind generation

Cited by 19 publications

References 40 publications

Neural Networks Mediating High-Level Mentalizing in Patients With Right Cerebral Hemispheric Gliomas

Neural Networks Mediating High-Level Mentalizing in Patients With Right Cerebral Hemispheric Gliomas

Uncovering the neuroanatomical correlates of cognitive, affective and conative theory of mind in paediatric traumatic brain injury: a neural systems perspective

Seeing More Than Human: Autism and Anthropomorphic Theory of Mind

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