Association Between a Glucokinase Regulator Genetic Variant and Metabolic Syndrome in Taiwanese Adolescents

Chang, Hsiao-Wen; Lin, Fu-Huang; Li, Pengfei; Huang, Chia‐Luen; Chu, Nain-Feng; Su, Sheng-Chiang; Lu, Chieh-Hua; Lee, Chien-Hsing; Hung, Yi‐Jen; Hsieh, Chang‐Hsun

doi:10.1089/gtmb.2015.0241

Cited by 12 publications

(13 citation statements)

References 38 publications

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“…Previous reports demonstrated the role of GCKR rs780094 polymorphism in dyslipidemia, high triglyceride level and impaired fasting glucose (30)(31)(32). In a study, in Taiwan the association between GCKR rs780094 and MetS and HDl-C has been reported among adolescents (33).…”

Section: Discussionmentioning

confidence: 92%

Interaction of GCKR, MLXIPL and FADS Genes Polymorphisms with Obesity in the Occurrence of Childhood Metabolic Syndrome

Hovsepian¹,

Javanmard²,

Mansourian³

2018

ME-JFM

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Objective: Considering the implication of better understanding of metabolic syndrome (MetS) pathophysiology in designing proper preventative and management strategies and the fact that dyslipidemia is one of the early and common features of MetS, the aim of this study was to investigate the interaction of some lipid regulatory genes polymorphisms with obesity in the occurrence of MetS in children. Methods: In this nested case-control study, 300 frozen samples of normal weight and 300 samples of overweight/obese children aged 10-18 years old from the CASPIAN III study samples were selected randomly. The studied population was classified into four groups as follows: Normal weight participants with and without MetS and overweight/obese participants with and without MetS. Allelic and genotypic frequencies of GCKR (rs780094), GCKR(rs1260333), MLXIPL(rs3812316) and FADS(rs174547) polymorphisms were determined and compared in the four studied groups. Interaction of each studied Single Nucleotide Polymorphisms (SNPs) with obesity in the occurrence of MetS was evaluated also.

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Section: Discussionmentioning

confidence: 92%

Interaction of GCKR, MLXIPL and FADS Genes Polymorphisms with Obesity in the Occurrence of Childhood Metabolic Syndrome

Hovsepian¹,

Javanmard²,

Mansourian³

2018

ME-JFM

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“…The rs780094 polymorphism in GCKR is strongly associated with elevated triglyceride concentrations and metabolic syndrome . In addition, the T allele of rs780094 is associated with a decreased risk of susceptibility to T2DM in certain populations .…”

Section: Introductionmentioning

confidence: 99%

TheGCKRGene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population

Anghebem-Oliveira

Webber

Alberton

et al. 2016

J. Clin. Lab. Anal.

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“…As in the present study in the Iranian population, CT genotypes of the three SNPs were associated with lower HDL-C levels. In another study where the participants were Taiwanese Adolescents, T-allele carriers of rs780094 were more highly represented among participants with low HDL-C levels [42].…”

Section: Discussionmentioning

confidence: 94%

GCKR Common Functional Polymorphisms are Associated with Metabolic Syndrome and its Components: A 10-Year Retrospective Cohort Study in Iranian Adults

Zahedi

Akbarzadeh

Sedaghati-khayat

et al. 2020

Preprint

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Background: Some previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to examine these findings, to our knowledge for the first time, in Iranian adults. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years.Methods: Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19-88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study.Results: In the current study, we have consistently replicated the association between the T-allele of GCKR SNPs and higher triglyceride levels and lower fasting blood sugar levels (p<0.05) in the Iranian population. The CT genotype of all three variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p<0.05).Conclusions: Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

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Association Between a Glucokinase Regulator Genetic Variant and Metabolic Syndrome in Taiwanese Adolescents

Abstract: The GCKR rs780094 polymorphism is associated with low HDL-C levels and MetS incidence in Taiwanese adolescents.

Cited by 12 publications

References 38 publications

Interaction of GCKR, MLXIPL and FADS Genes Polymorphisms with Obesity in the Occurrence of Childhood Metabolic Syndrome

Interaction of GCKR, MLXIPL and FADS Genes Polymorphisms with Obesity in the Occurrence of Childhood Metabolic Syndrome

TheGCKRGene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population

GCKR Common Functional Polymorphisms are Associated with Metabolic Syndrome and its Components: A 10-Year Retrospective Cohort Study in Iranian Adults

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