Optical frequency-domain imaging and pulmonary angioscopy in chronic thromboembolic pulmonary hypertension

Chibana, Hidetoshi; Tahara, Nobuhiro; Isobe, Naoki; Sasaki, Masahiro; Sasaki, Motoki; Nakayoshi, Takaharu; Ohtsuka, Masanori; Yokoyama, Shinji; Sasaki, Ken-ichiro; Ueno, Takayoshi

doi:10.1093/eurheartj/ehv736

Cited by 6 publications

(3 citation statements)

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“…We enrolled 7 female patients in this study who were diagnosed as CTEPH, confirmed by ventilation-perfusion RI scans and computed tomography (CT), optimal coherence tomography/OFDI and/or pulmonary angiography [6] , [7] , [8] . After medical therapy and balloon pulmonary angioplasty (BPA) [10] , we performed this study in stabilized pulmonary hemodynamics condition.…”

Section: Methodsmentioning

confidence: 99%

“…CTEPH is usually diagnosed by mismatched perfusion defects on ventilation-perfusion lung scintigraphy and chronic thromboembolic signs on computed tomography (CT) scan and/or conventional pulmonary angiography. Further, we have reported that optical frequency-domain imaging (OFDI) and pulmonary angioscopy are also able to detect thin chronic thrombus [6] , [7] , [8] . These techniques can be useful, especially when there are some difficulties in CT scan and/or pulmonary angiography.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary artery dysfunction in chronic thromboembolic pulmonary hypertension

Chibana

Tahara

Isobe

et al. 2017

IJC Heart & Vasculature

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BackgroundUnresolved thromboemboli in the pulmonary arteries (PA) is known to cause chronic thromboembolic pulmonary hypertension (CTEPH). However, it remains unknown if vascular dysfunction in pulmonary arteries exists in patients with CTEPH.Methods and resultsWe enrolled 7 female patients with CTEPH in this study, who have stable pulmonary hemodynamics after balloon pulmonary angioplasty (age; 73.6 ± 3.0 years old, mean right atrial pressure; 4.1 ± 0.4 mm Hg, mean pulmonary arterial pressure; 29.4 ± 2.7, mean pulmonary artery wedge pressure; 8.1 ± 1.2, pulmonary vascular resistance; 397.3 ± 51.7 dynes, cardiac index; 3.1 ± 0.2 L/min/m2). Pulmonary artery vascular function was evaluated by measuring pulmonary artery vasomotion in response to acetylcholine (Ach) at 10-month follow-up after balloon pulmonary angioplasty. All pulmonary vasoactive drugs were discontinued on the day of the procedures. The endothelium-dependent vasomotor response was evaluated by intra-pulmonary artery infusion of Ach at the dose of 10− 8 mol/l, and the vaso-spastic response was at 10− 6 mol/l. We evaluated vasomotor responses at the same segment in each patient, by measuring % changes of luminal area detected by quantitative pulmonary arterial optical frequency-domain imaging (OFDI), where OFDI catheter was fixed during the procedure. Endothelial dysfunction was observed at the dose of Ach at 10− 8 mol/l and vasoconstriction was also confirmed at the dose of Ach at 10− 6 mol/l in the diseased pulmonary arteries in CTEPH.ConclusionsThese results indicated that the pulmonary artery dysfunction exists in patients with CTEPH, which may be involved in the pathogenesis and progression of CTEPH.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary artery dysfunction in chronic thromboembolic pulmonary hypertension

Chibana

Tahara

Isobe

et al. 2017

IJC Heart & Vasculature

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“…An important step in the diagnostic algorithm for PH is the performance of V single-photon emission computed tomographic scan were associated with poor outcome. It is possible that occult thromboembolic lesions could be revealed by using specialized methods such as optical frequency domain imaging or pulmonary angioscopy (111).…”

Section: Imagingmentioning

confidence: 99%