Antioxidative Activity of Colostrum and Human Milk

Marinković, Vesna; Ranković-Janevski, Milica; Spasić, Snežana; Nikolić‐Kokić, Aleksandra; Lugonja, Nikoleta; Djurović, Dijana; Miletić, Srđan; Vrvić, Miroslav M.; Spasojević, Ivan

doi:10.1097/mpg.0000000000001090

Cited by 38 publications

(38 citation statements)

References 49 publications

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“…For this reason, we included mothers who had delivered before 34 weeks' gestation in the study. Similar to previous studies, [33][34][35] we found that colostrum has the highest TAC level which decreased in the later stages of lactation. However, decrease in TAC was not statistically significant in preterm BM.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Total Antioxidant Capacity and Total Oxidant Status of Preterm and Term Breast Milk during the Course of Lactation and within a Nursing Session

et al. 2019

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Objective Breast milk (BM) contains antioxidant molecules which may offer protection against oxidative stress (OS). We aim to investigate oxidant–antioxidant balance in preterm BM during the course of lactation and within a nursing session. Study Design Total antioxidant capacity (TAC) and total oxidant status (TOS) were measured in colostrum, transitional, and mature BM samples of preterm infants born earlier than 34th week of pregnancy and healthy term infants. Oxidative stress index (OSI) was calculated. Foremilk and hindmilk samples were collected separately. Results In colostrum and transitional milk, TAC (p < 0.001 and p = 0.001, respectively) and TOS (p = 0.005 and p < 0.001, respectively) were lower in preterm BM compared with term BM. OSI was also lower in preterm BM, but it was statistically significant only in transitional milk (p < 0.001). TAC was highest in colostrum and decreased through the course of lactation. However, the decrease in TAC was not statistically significant in preterm BM. Lowest values of TOS and OSI were observed in colostrum. In transitional term BM, hindmilk had a better oxidant–antioxidant profile as indicated by lower TOS and OSI. Conclusion Oxidant–antioxidant balance is preserved in BM in every stage of lactation. Preterm BM has lower OSI which may offer benefits to preterm newborn against OS.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Total Antioxidant Capacity and Total Oxidant Status of Preterm and Term Breast Milk during the Course of Lactation and within a Nursing Session

et al. 2019

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“…Colostrum is essential in the antioxidant mechanism of the newborn [56][57][58][59] and our results demonstrate, the antioxidant potential of CCM exosomes on canine fibroblast.…”

Section: Exosomes Play a Key Role In Cell-to-cell Communication And Cmentioning

confidence: 58%

Canine colostrum exosomes: characterization, influence on canine mesenchymal stem cell secretory profile and fibroblast anti-oxidative capacity

Villatoro

Martín-Astorga

Alcoholado

et al. 2019

Preprint

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Background Colostrum is a specific secretion of the mammary gland fundamental for the survival of the puppy during the first weeks after birth. It contains important bioactive molecules involved in the passive immunity and the maturation of various organs, highlighting small vesicles named exosomes. Exosomes have not been described yet in canine colostrum milk, where its role is crucial in dam-newborn communication for the development of the neonate. Results Exosomes were abundant in canine colostrum milk and appeared with a characteristic cup-shaped morphology and well-defined round vesicles. Their size distribution was between 37−140 nm and western blot analysis showed an expression of specific exosomal markers. Proteomic analysis revealed a total of 826 proteins in exosomes cargo. We also found that exosomes modified proliferation and secretory profile in canine mesenchymal stem cells derived from bone marrow and adipose tissue, differently according to their origin. Besides, the exosomes of canine colostrum demonstrated a potent antioxidant effect on canine fibroblast. Conclusions We described for the first time the isolation and characterization of milk exosomes from canine colostrum. Our findings highlight the abundant presence of exosomes in the colostrum of the canine species and contribute to explain their important antioxidant capacity after parturition and their role in the modulation of cell development and tissue differentiation in the newborn, where mesenchymal stem cells seem to play a key role.

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“…Transitional milk is thinner, watery and sweeter, compared to colostrum. Compared with colostrum and mature milk of mothers of preterm infants, transitional milk has lower ORP value indicating better TAC than colostrum or mature milk. Breast milk from mothers of preterm infants of 29–34 gestation weeks, collected up to 40 weeks of postnatal age showed a temporal change over the first 3 weeks of lactation, approaching zero with the achievement of term age .…”

Section: Discussionmentioning

confidence: 92%