Decline in sperm count and motility in young adult men from 2003 to 2013: observations from a U.S. sperm bank

Centola, Grace M.; Blanchard, A.; Demick, J.; Li, S.; Eisenberg, Michael L.

doi:10.1111/andr.12149

Cited by 70 publications

(43 citation statements)

References 45 publications

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“…This suggests that the toxicity of NH 4 CL and/or Na 2 S treatments (used in current investigation) might be not very high just that spermatozoa motility was declined while the spermatozoa survival was not impaired. This phenomenon was also found by the epidemiology studies12345.…”

Section: Discussionsupporting

confidence: 75%

“…Numerous emerging studies suggest that air pollutants may cause a decline in the motility of human spermatozoa12345. NH 3 and H 2 S are air pollutants that can be free or bound to air PM891617.…”

Section: Discussionmentioning

confidence: 99%

“…A number of recent publications have reported a decline in spermatozoa motility12345. Other parameters of human spermatozoa quality have also decreased during the past few decades36.…”

mentioning

confidence: 99%

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Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways

Zhao

Zhang

Liu

et al. 2016

Sci Rep

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A number of emerging studies suggest that air pollutants such as hydrogen sulfide (H2S) and ammonia (NH3) may cause a decline in spermatozoa motility. The impact and underlying mechanisms are currently unknown. Boar spermatozoa (in vitro) and peripubertal male mice (in vivo) were exposed to H2S and/or NH3 to evaluate the impact on spermatozoa motility. Na2S and/or NH4Cl reduced the motility of boar spermatozoa in vitro. Na2S and/or NH4Cl disrupted multiple signaling pathways including decreasing Na+/K+ ATPase activity and protein kinase B (AKT) levels, activating Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) and phosphatase and tensin homolog deleted on chromosome ten (PTEN), and increasing reactive oxygen species (ROS) to diminish boar spermatozoa motility. The increase in ROS might have activated PTEN, which in turn diminished AKT activation. The ATP deficiency (indicated by reduction in Na+/K+ ATPase activity), transforming growth factor (TGFβ) activated kinase-1 (TAK1) activation, and AKT deactivation stimulated AMPK, which caused a decline in boar spermatozoa motility. Simultaneously, the deactivation of AKT might play some role in the reduction of boar spermatozoa motility. Furthermore, Na2S and/or NH4Cl declined the motility of mouse spermatozoa without affecting mouse body weight gain in vivo. Findings of the present study suggest that H2S and/or NH3 are adversely associated with spermatozoa motility.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways

Zhao

Zhang

Liu

et al. 2016

Sci Rep

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“…The transwomen sperm bankers were significantly younger than the cismen sperm bankers, but the majority were adults, so we expected normal semen parameters (Centola et al , 2016). This may point to unreported hormonal therapy or some inherent physiologic issues with spermatogenesis in transwomen which has yet to be elucidated.…”

Section: Discussionmentioning

confidence: 96%

Sperm cryopreservation of transgender individuals: trends and findings in the past decade

Rodríguez

Gabrielsen

et al. 2018

Andrology

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“…These have the potential to increase our understanding of the familial and environmental components associated with male factor infertility and expand the phenotypic definition to include multiple diseases. Within the last 10 years, the testicular dysgenesis syndrome (TDS) hypothesis, which proposes that disturbed testicular development in utero may result in male reproductive disorders, has been suggested as an explanation for a constellation of symptoms and diseases, which includes poor semen quality (Swan et al, 2000;Jouannet et al, 2001;Skakkebaek et al, 2001;McGlynn et al, 2003;Bray et al, 2006a, b;Centola et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Risk of childhood mortality in family members of men with poor semen quality

et al. 2016

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STUDY QUESTION: What is the familial childhood mortality in first-degree (FDR) and second-degree relatives (SDR) of patients undergoing semen analysis (SA)?SUMMARY ANSWER: The relationship between infertility and congenital malformations (CM) in offspring is complex, with an increased risk of death due to CM in FDR, but not SDR, of men with lower semen parameters.WHAT IS KNOWN ALREADY: Semen quality is an established predictor of men's somatic health. We can gain a better understanding of possible genetic or environmental determinants of the infertility phenotype by exploring familial aggregation of childhood mortality in relatives of men with poor semen quality.STUDY DESIGN, SIZE, DURATION: Retrospective cohort study from the Subfertility, Health and Assisted Reproduction study (cohort compiled 1996-2011) linked with patient/familial information from the Utah Population Database (UPDB). Index cases included a clinicreferred sample of 12 889 men who underwent SA and had adequate familial and follow-up data in the UPDB. Parameters of semen quality included: semen concentration, sperm count, motility, total motile count, sperm head morphology, sperm tail morphology and vitality.PARTICIPANTS/MATERIALS, SETTING, METHODS: SA data were collected from two tertiary medical center andrology laboratories that have captured~90% of all SA performed in Utah since 2004. Age-and sex-matched fertile controls were selected to create the comparison group for determining risk of childhood death (to age 20 years) in family members. A total of 79 750 siblings and 160 016 aunts/ uncles were used to investigate the familial aggregation of childhood mortality. The main outcome was childhood mortality in FDR and SDR of men with SA and their matched controls. All-cause and cause-specific Cox proportional hazard models were used to test the association between semen quality and childhood mortality in family members. Cause-specific models were considered for cancer and CM. MAIN RESULTS AND THE ROLE OF CHANCE:In the cohort of men with SA, there were 406 (1.0%) deaths in FDR and 772 (1.1%) deaths in SDR due to any cause. There was no significant difference in the risk of all-cause childhood mortality between the relatives of men with SA and the fertile control group [hazard ratio (HR) Female = 1.08, 95% CI = 0.88, 1.32; HR Male = 0.88, 95% CI = 0.75, 1.04]. We found no association between semen quality and risk for childhood cancer mortality in FDR or SDR (HR FDR = 0.98, 95% CI = 0.62, 1.54; HR SDR = 1.12, 95% CI = 0.83, 1.50). The FDR of men with SA and fertile controls were followed on average for 19.71 and 19.73 years, respectively. During this period of follow-up, FDR of men with SA had an unadjusted 40% relative risk of increased CM-related death. After stratifying by semen parameters and adjusting for birth year, we found FDR of men with worse semen quality, and notably azoospermic men (HR = 2.69, 95% CI = 1.24,5.84), were at higher risk of CM-related death. LIMITATIONS REASONS FOR CAUTION:A large proportion of men with SA in the stu...

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Decline in sperm count and motility in young adult men from 2003 to 2013: observations from a U.S. sperm bank

Cited by 70 publications

References 45 publications

Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways

Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways

Sperm cryopreservation of transgender individuals: trends and findings in the past decade

Risk of childhood mortality in family members of men with poor semen quality

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