Noradrenaline Reuptake Inhibition Impairs Cortical Output and Limits Endurance Time

Klass, Malgorzata; Duchateau, Jacques; Rabec, Samuel; Meeusen, Romain; Roelands, Bart

doi:10.1249/mss.0000000000000879

Cited by 27 publications

(34 citation statements)

References 40 publications

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“…This demonstrates that altered brain neurotransmission is able to affect whole-body endurance performance and that this effect is associated with an altered RPE to power output ratio (in the case of DA, a decreased ratio). Klass et al [76] showed that muscle endurance performance is affected in a similar way. A noradrenaline reuptake inhibitor reduced endurance time by 15.6 %.…”

Section: A Potential Role For Brain Neurotransmittersmentioning

confidence: 95%

“…This was associated with a greater rate of supraspinal impairment and increase in RPE. Participants experienced the same intensity of intermittent contractions as harder to perform after administration of a noradrenaline reuptake inhibitor, without affecting the fatigue-related intramuscular impairments [76]. Pageaux et 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 al.…”

Section: A Potential Role For Brain Neurotransmittersmentioning

confidence: 99%

“…This was associated with a greater rate of supraspinal impairment and increase in RPE. Participants experienced the same intensity of intermittent contractions as harder to perform after administration of a noradrenaline reuptake inhibitor, without affecting the fatigue-related intramuscular impairments [76]. Pageaux et al [35,20,17] stated that neural activity increases the extracellular concentration of adenosine (an inhibitory neurotransmitter; [77]) and that brain adenosine accumulation reduces endurance performance [78].…”

Section: A Potential Role For Brain Neurotransmittersmentioning

confidence: 99%

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The Effects of Mental Fatigue on Physical Performance: A Systematic Review

et al. 2017

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Abstract:Background: Mental fatigue is a psychobiological state caused by prolonged periods of demanding cognitive activity. Mental fatigue has recently been suggested to affect physical performance. Objective: To evaluate the literature on the impairment in physical performance due to mental fatigue and to create an overview of the potential factors underlying this effect. Data Sources: Two electronic databases, PubMed and Web of Science (until 28 April 2016) were searched. Eligibility criteria for selecting studies: Studies had to be designed to test whether mental fatigue influenced performance on a physical task or influenced physiological and/or perceptual responses during the physical task. Studies using short (<30 min) self-regulatory depletion tasks were excluded from the review. Results: Eleven articles were included, of which six were of strong and five of moderate quality. The general finding was a decline in endurance performance (decreased timeto-exhaustion and self-selected power output/velocity or increased completion-time) due to mental fatigue, associated with a higher than normal perceived exertion. Physiological variables traditionally associated with endurance performance (heart rate, blood lactate, oxygen uptake, cardiac output, VO2) were unaffected by mental fatigue. Maximal strength, power and anaerobic work were observed not to be affected by mental fatigue. Conclusion: Duration and intensity of the physical task appear to be important factors in the decrease in physical performance due to mental fatigue. The most important factor responsible for the negative impact of mental fatigue on endurance performance is a higher perceived exertion. Powered by Edit orial Manager® and ProduXion Manager® from Aries Syst em s Corporat ionA E Dear editor, we thank you for the revisions. We also revised the paper once more on grammar and vocabulary and subsequently adjusted some words, rephrased a couple of sentences and removed some redundant sentences (mainly in section 4.5 and 5). We hope you agree with these specific changes and want to emphasize that no changes were made to the content of the manuscript (in order to demonstrate this all deleted words and sentences are also indicated in the manuscript with tracked changes).1. Section 3.4 please number the subsections in this section 3.4. This was adjusted.3. Section 4.5, sentence 1This was adjusted. Compliance with Ethical Standards section S B SM This was adjusted. Conflicts of Interest section S B S MThis was adjusted.6. References list the References list no longer has the corrected formatting that was evident in the Revision 1 version of this list. Therefore, can you please reinstate the Revision 1 version, which incorporated the requested formatting changes from the submitted version. However, please also note that the revised version of the References list in Revision 1 had 77 references, whereas the version in Revision 2 has 82 references. Therefore, the format-corrected version in Revision 1 cannot simply be transplanted into Revision 3 it ...

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Section: A Potential Role For Brain Neurotransmittersmentioning

confidence: 95%

Section: A Potential Role For Brain Neurotransmittersmentioning

confidence: 99%

“…This was associated with a greater rate of supraspinal impairment and increase in RPE. Participants experienced the same intensity of intermittent contractions as harder to perform after administration of a noradrenaline reuptake inhibitor, without affecting the fatigue-related intramuscular impairments [76]. Pageaux et al [35,20,17] stated that neural activity increases the extracellular concentration of adenosine (an inhibitory neurotransmitter; [77]) and that brain adenosine accumulation reduces endurance performance [78].…”

Section: A Potential Role For Brain Neurotransmittersmentioning

confidence: 99%

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The Effects of Mental Fatigue on Physical Performance: A Systematic Review

et al. 2017

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“…Operationally, it is often defined as an exercise-induced decrease in maximal voluntary activation level ( Pageaux et al, 2015 ). A mechanism that has been proposed to play a role within this kind of fatigue is for example challenged oxygenation of the brain during exercise ( Secher et al, 2008 ), but also neurochemical and thermodynamic changes of the cerebral homeostasis have been proposed to lead to central fatigue ( Kayser, 2003 ; Nybo and Secher, 2004 ; Klass et al, 2016 ). However, similarly to the proposed peripheral mechanisms of fatigue, the reductionistic pitfall to link these central mechanisms with the occurrence of exercise-induced fatigue based on the concept of a critical threshold, has to be avoided, i.e., a linear model in which increases or decreases in brain neurotransmitter concentrations cause fatigue ( Gibson and Noakes, 2004 ).…”

Section: Fatigue In Exercise Sciencementioning

confidence: 99%

Bridging Exercise Science, Cognitive Psychology, and Medical Practice: Is “Cognitive Fatigue” a Remake of “The Emperor’s New Clothes”?

et al. 2018

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Fatigue is such a multifaceted construct it has sprouted specific research fields and experts in domains as different as exercise physiology, cognitive psychology, human factors and engineering, and medical practice. It lacks a consensus definition: it is an experimental concept, a symptom, a risk, a cause (e.g., of performance decrement) and a consequence (e.g., of sleep deprivation). This fragmentation of knowledge leads to slower dissemination of novel insights, and thus to a poorer research. Indeed, what may seem as a novel result in one field, may very well be old news in another, hence leading to this “innovation” being a scientific equivalent to the emperor’s new clothes. The current paper aims to describe the common denominator in the different areas of expertise where fatigue is investigated. Indeed, rather than focusing on the differences in semantics and conceptualization, we hope that identifying common concepts may be inductive of easier multidisciplinary research. Considering the vastness of fatigue research in all areas identified as relevant-cognitive science, exercise physiology, and medical practice, this analysis has not the ambition to be an exhaustive review in all domains. We have reviewed the fatigue concepts and research in these areas and report the ones that are used to describe the proposed common model to be further investigated. The most promising common feature to cognitive science, exercise physiology and clinical practice is the notion of “perceived effort.” This allows to account for interindividual differences, as well as for the situational variations in fatigue. It is applicable to both mental and physical constructs. It integrates motivational and emotional dimensions. It overcomes current polemics in various research fields, and it does not draw on any semantic ambiguity. We thus suggest a new model of fatigue and performance, whether this performance is mental or physical; and whether it is in a clinical range or relates to optimal functioning.

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“…The interaction between exercise and brain catecholamines concentrations does not only affect motivation but also the whole process of central fatigue, as dopamine (DA) and norepinephrine (NE) are vital for activation of the prefrontal cortex (PFC), which is thought to control central fatigue (Klass et al, 2016;Robertson & Marino, 2016).…”

Section: Introductionmentioning

confidence: 99%

Central fatigue theory and endurance exercise: Toward an interoceptive model

McMorris

Barwood

Corbett

2018

Neuroscience & Biobehavioral Reviews

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We propose a model of exercise-induced central fatigue based on interoception and motivation. Predictions of the expected sensory feedback are fed forward by the dorsolateral (DL) prefrontal cortex (PFC) to the anterior insula cortex (AIC). During exercise, the AIC receives feedback from lamina Ⅰ lateral spinothalamic and nucleus tractus solitarii medullothalamic pathways. The feedback is compared to the predictions in order to generate a current awareness state, which is forwarded to the anterior cingulate cortex (ACC), ventromedial (VM)PFC and lateral (L)PFC. The LPFC integrates the information and makes a decision as to whether to continue or stop. The decision is dependent upon interaction with the substantia nigra pars compacta and ventral tegmental area dopamine (DA), and locus coeruleus (LC)-norepinephrine (NE) systems. Phasic activation of DA and NE neurons appears to be necessary for maintenance of goal-related action but the VMPFC and ACC, which project to the LC, induce tonic NE activity when the rewards are thought to be not worth the cost thus fatigue is perceived.

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Noradrenaline Reuptake Inhibition Impairs Cortical Output and Limits Endurance Time

Abstract: These findings suggest that because of the noradrenaline reuptake inhibition, the output from the motor cortex is decreased at a greater rate than that in the PLA condition, contributing thereby to shorten endurance time.

Cited by 27 publications

References 40 publications

The Effects of Mental Fatigue on Physical Performance: A Systematic Review

The Effects of Mental Fatigue on Physical Performance: A Systematic Review

Bridging Exercise Science, Cognitive Psychology, and Medical Practice: Is “Cognitive Fatigue” a Remake of “The Emperor’s New Clothes”?

Central fatigue theory and endurance exercise: Toward an interoceptive model

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