Abstract:Background The number of hematological malignancies is expected to increase as the Danish population ages within the next few decades. Despite this, data on the course of hematological cancers among the oldest patients are sparse with many intervention studies focusing on younger age groups. The aim of this study is to present Danish incidence and mortality rates among older patients with non-Hodgkin lymphomas (NHL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), and acute myeloid leukemia (AML). M… Show more
“…National, epidemiological data have shown increased incidence and mortality of cancer with age (25)(26)(27)(28)(29). In the present study, the relation between sex and survival duration was still statistically significant after adjusting for age.…”
Background/Aim: An increasing number of patients undergo surgical treatment for metastatic spinal cord compression (MSCC). However, the possible role of sex as an independent predictor of long-term survival has not been studied. This study aimed to examine whether sex is associated with long-term survival after surgical treatment in patients with MSCC. Patients and Methods: A total of 110 patients were operated on for MSCC from 2005 through 2006. The relation between sex and overall survival was investigated. The followup period was 10 years. Results: Survival time was significantly longer for women compared to men (mean±SD: 29±5.2 vs. 14±3.6 month (p=0.01). With adjusted analysis, this difference remained statistically significant. After adjusting for specific primary tumor type and time since surgery, the hazardratio of 10-year survival for men compared to women was 1.47 (95% confidence intervaI=1. 01-2.18, p=0.048). Conclusion: These findings indicate that sex is associated with long-term survival in patients treated for MSCC.
“…National, epidemiological data have shown increased incidence and mortality of cancer with age (25)(26)(27)(28)(29). In the present study, the relation between sex and survival duration was still statistically significant after adjusting for age.…”
Background/Aim: An increasing number of patients undergo surgical treatment for metastatic spinal cord compression (MSCC). However, the possible role of sex as an independent predictor of long-term survival has not been studied. This study aimed to examine whether sex is associated with long-term survival after surgical treatment in patients with MSCC. Patients and Methods: A total of 110 patients were operated on for MSCC from 2005 through 2006. The relation between sex and overall survival was investigated. The followup period was 10 years. Results: Survival time was significantly longer for women compared to men (mean±SD: 29±5.2 vs. 14±3.6 month (p=0.01). With adjusted analysis, this difference remained statistically significant. After adjusting for specific primary tumor type and time since surgery, the hazardratio of 10-year survival for men compared to women was 1.47 (95% confidence intervaI=1. 01-2.18, p=0.048). Conclusion: These findings indicate that sex is associated with long-term survival in patients treated for MSCC.
“… 23 In accordance with data reported by other countries, we did not find notable changes in the general population’s incidence of hematologic malignant neoplasm during this relatively short and recent period. 24 , 25 , 26…”
Key Points
Question
Which hematologic malignant neoplasm types are more prone to develop after breast cancer diagnosis?
Findings
In this cohort study of 439 704 French women, breast cancer survivors with an incident breast cancer diagnosis had statistically significantly higher standardized incidence rate ratios of acute myeloid leukemia and myelodysplastic syndrome compared with women in the general population. A slight increase in the incidence of multiple myeloma and acute lymphoblastic leukemia was noted.
Meaning
This study sugests that acute myeloid leukemia, myelodysplastic syndrome, and acute lymphoblastic leukemia occur more frequently among breast cancer survivors than among women in the general population; continuous monitoring and further investigations into the underlying mechanisms of hematologic malignant neoplasms are necessary.
“…There is no precise information regarding the epidemiologic aspects of acute myeloid leukemia (AML) in Mexico, but 600 new cases were reported in 1998 [40]. AML increases with age, and its incidence varies from 2-3 per 100,000 in young people to 15-20 in the older population [41]. The risk of developing AML increases 10 times after reaching 30 years, from 1 to 10 cases per 100,000/year [42].…”
Information on hematology diseases derived of regional registries in low-middle income countries is a reasonable alternative to complement and update national registries.
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