The prevalence of human papillomavirus infection in Iranian patients with sinonasal inverted papilloma

Abstract

This study suggests that HPV6 and 11 may be involved in the development of IP, but HPV16 and 18 likely play an important role in the progression from benign to malignant form of IP.

Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma

“…A relationship between HPV and SN‐SCC was first reported in 1989 in a study of sinonasal papillomas; two thirds of the papillomas were HPV‐positive, including all of the cases that progressed to SN‐SCC . Since then, numerous studies have detected HPV in exophytic, inverted, and fungiform sinonasal papillomas. Furthermore, HPV positivity has been identified in 40% to 100% of SN‐SCC that transformed from inverted papillomas .…”

Type‐specific human papillomavirus prevalence in cervical intraepithelial neoplasia and cancer in Iran

“…All samples were subjected to HPV amplification by PCR or nested-PCR assays using GP5+/6+ primer pair or MY09, 11/GP5+, 6+ primer pairs, respectively to obtain almost 150 bp amplicon of L1 gene. 20 The PCR reactions was performed in a 50 µL reaction mixture including 100-200 ng of DNA template, 2.5 mM of MgCl 2 , 10 pmol of each primer (GP5+/6+), 50 mM of each dNTP and 2 U of Taq DNA polymerase. PCR amplification cycles were included as follows: an initial 3-min denaturation at 94°C, followed by 45 cycles of 94°C for 30 s, 50°C for 45 s, and 72°C for 1 min, and final elongation for 5 min at 72°C.…”

“…To overcome negative results due to low copy number of HPV DNA, all negative samples were checked using nested-PCR by the consensus MY09/MY11 primer pair (outer primers) and the GP5 +/GP6+ primer pair (inner primer) as described previously. 20…”

Acute proptosis: Unusual initial presentation of sinonasal inverted papilloma

“…Inverted papilloma is a rare disease in the general population, with only 0.75-1.5/100 000 incidence rate per year, and more prevalent in male than female [1]. It arises from an ectodermal respiratory epithelium lining on the lateral nasal wall and paranasal sinuses.…”

“…Several proposed risk factors include exposure to organic solvents, welding fumes, nickel compound, cigarette smoking and infectious agents. Infection by human papilloma virus has been considered as a potential causal agent in the pathogenesis of inverted papilloma, which influences the transformation of lesion from benign to malignant [1,3,4].…”