The association between vitamin D and C-reactive protein levels in patients with inflammatory and non-inflammatory diseases

Kruit, Adrian; Zanen, Pieter

doi:10.1016/j.clinbiochem.2016.01.002

Cited by 42 publications

(38 citation statements)

References 30 publications

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“…The anti-inflammatory effects of 1,25(OH) 2 D 3 were supported by our ex vivo data for HK19F where vitamin D-insufficient individuals had significantly higher IFN-γ than those who were sufficient, consistent with earlier data [44,45,46]. Down-regulation of pattern recognition receptor expression on innate immune cells by 1,25(OH) 2 D 3 would be advantageous in the control of an excessive inflammatory environment [47].…”

Section: Discussionsupporting

confidence: 92%

Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection

et al. 2016

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Vitamin D induces a diverse range of biological effects, including important functions in bone health, calcium homeostasis and, more recently, on immune function. The role of vitamin D during infection is of particular interest given data from epidemiological studies suggesting that vitamin D deficiency is associated with an increased risk of infection. Vitamin D has diverse immunomodulatory functions, although its role during bacterial infection remains unclear. In this study, we examined the effects of 1,25(OH)2D3, the active metabolite of vitamin D, on peripheral blood mononuclear cells (PBMCs) and purified immune cell subsets isolated from healthy adults following stimulation with the bacterial ligands heat-killed pneumococcal serotype 19F (HK19F) and lipopolysaccharide (LPS). We found that 1,25(OH)2D3 significantly reduced pro-inflammatory cytokines TNF-α, IFN-γ, and IL-1β as well as the chemokine IL-8 for both ligands (three- to 53-fold), while anti-inflammatory IL-10 was increased (two-fold, p = 0.016) in HK19F-stimulated monocytes. Levels of HK19F-specific IFN-γ were significantly higher (11.7-fold, p = 0.038) in vitamin D-insufficient adults (<50 nmol/L) compared to sufficient adults (>50 nmol/L). Vitamin D also shifted the pro-inflammatory/anti-inflammatory balance towards an anti-inflammatory phenotype and increased the CD14 expression on monocytes (p = 0.008) in response to LPS but not HK19F stimulation. These results suggest that 1,25(OH)2D3 may be an important regulator of the inflammatory response and supports further in vivo and clinical studies to confirm the potential benefits of vitamin D in this context.

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Section: Discussionsupporting

confidence: 92%

Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection

et al. 2016

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“…Indeed, ageing itself is associated with low-grade chronic inflammation and elevated CRP and in light of the aforementioned associations with 25(OH)D status, a stronger effect of 25(OH)D may thus be more distinctly observed in the elderly compared with younger individuals in whom CRP levels are expectedly lower ( 37 ) .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA)

et al. 2017

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Recent evidence suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers. However, there are limited studies investigating associations between vitamin D levels and inflammatory markers in the general population and much of this evidence in older adults is inconclusive. Therefore, this study investigates the cross-sectional association of serum 25-hydroxyvitamin D (25(OH)D) levels with inflammatory markers in 5870 older English adults from wave 6 (2012–2013) of the English Longitudinal Study of Ageing (ELSA). ELSA is a large prospective observational study of community-dwelling people aged 50 years and over in England. Serum 25(OH)D levels, C-reactive protein (CRP) levels, plasma fibrinogen levels, white blood cell count (WBC), age, season of blood collection, waist circumference, total non-pension household wealth, measures of health and health behaviours that included depression, number of cardiovascular, non-cardiovascular conditions and difficulties in activities of daily living, smoking, and physical activity were measured. There was a significant negative association between low 25(OH)D levels (≤30 nmol/l) and CRP (OR 1·23, 95 % CI 1·00, 1·51) and WBC (OR 1·35, 95 % CI 1·13, 1·60) that remained after adjustment for a wide range of covariates of clinical significance. However, for fibrinogen, the association did not remain significant when waist circumference was entered in the final model. Our findings showed that 25(OH)D levels were associated with two out the three inflammatory markers investigated. The independent and inverse association between serum 25(OH)D levels and inflammation suggests a potential anti-inflammatory role for vitamin D in older English individuals from the general population.

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“…If there is no constitutive activity, the agonist would be an active agonist. When the constitutive activity is present, the Protean agonist would be an inverse agonist [23].…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis and Osteoporosis: A Case Study

Raghavan¹

2017

J Arthritis

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Metadichol ® is a Nano emulsion of long-chain alcohols called as Policosanol and is present in foods such as rice, sugar cane, wheat, and peanuts. Metadichol ® acts on Nuclear Vitamin D receptors (VDR) that are present in cells throughout the body to stimulate the immune system and inhibit a variety of disease processes, resulting from inflammation to infection [1].We present a case study of a patient with Rheumatoid arthritis with the high levels of RF antibodies, CRP and ESR levels, and low bone mineral density leading to osteoporosis. The case report shows how Metadichol ® by its actions on the VDR has affected key biomarkers and mitigated the disease conditions without any side effects. Also, his bone density improved dramatically.Metadichol ® is safe because it consists of natural components of conventional foods and has no known adverse side effects. Its constituents are present in many foods that we consume every day.Metadichol ® has the potential to serve as a novel, safe solution to help patients with RA and other autoimmune diseases that confront the world today.

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The association between vitamin D and C-reactive protein levels in patients with inflammatory and non-inflammatory diseases

Cited by 42 publications

References 30 publications

Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection

Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection

Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA)

Rheumatoid Arthritis and Osteoporosis: A Case Study

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