Effects of pomegranate juice in circulating parameters, cytokines, and oxidative stress markers in endurance-based athletes: A randomized controlled trial

Abstract

35The aim of the present study was to assess the effects of pomegranate juice on the level of oxidative 36 stress in blood of endurance-based athletes. Pomegranate juice is rich in polyphenols, conferring it a 37 higher antioxidant capacity than other beverages with polyphenolic antioxidants. A randomized, improves MDA levels and carbonyls, decreasing the oxidative damage caused by the exercise.

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

“…In contrast to blood pressure, evidence regarding the effect of pomegranate on blood lipids of hemodialysis patients is rather controversial. Studies confirmed our results for serum triglyceride and HDL cholesterol improvement by pomegranate, but two other investigations reported no effect of either pomegranate polyphenol or PJ on these lipid profiles. Some of the controversy over the results of different studies may be explained by the baseline values of triglycerides and HDL cholesterol which probably should be at unfavorable levels in order for pomegranate to exert its benefit.…”

Does pomegranate consumption affect weight and body composition? A systematic review and meta‐analysis of randomized controlled clinical trials

“…Meta‐analysis of five RCTs (Fuster‐Muñoz et al, ; González‐Ortiz et al, ; Manthou et al, ; Sadegh Eghbali et al, ; Stockton et al, ) did not show a statistically significant difference in body fat percentage between intervention and control groups (WMD = −0.05, 95% CI: −1.66, 1.55, P = 0.947; Figure d). The between‐study heterogeneity was high ( Q statistic = 10.59, I 2 = 62.2%, P = 0.032), and subgroup analysis showed nonsignificant body fat percent reduction, similar to BMI subgroup, which was higher in obese people (WMD = −0.13, 95% CI: −4.79, 4.51, P = 0.954) compared with overweight (WMD = −0.04, 95% CI: −1.38, 1.30, P = 0.954) or normal individuals (WMD = 0.14, 95% CI: −1.99, 2.29, P = 0.892).…”

“…The main characteristics of 13 eligible trials are summarized in Table . Included studies were published between 2005 and 2017, which among them, four studies were performed in Iran (Ekhlasi et al, ; Hosseini et al, ; Sadegh Eghbali et al, ; Sohrab et al, ), two in the United States (Sumner et al, ; Wu et al, ) and UK (Lynn et al, ; Stockton et al, ), and other studies were conducted in Spain (Fuster‐Muñoz et al, ), Mexico (González‐Ortiz et al, ), Korea (Park et al, ), Greece (Manthou et al, ), and Serbia (Kojadinovic et al, ). The follow‐up period of included studies varied between 2 to 26 weeks.…”

“…Only, 1 out of 13 studies was conducted exclusively in men (Fuster‐Muñoz et al, ), and three in women (Kojadinovic et al, ; Park et al, ; Sadegh Eghbali et al, ), and the other seven trials were performed in both sexes (Ekhlasi et al, ; Lynn et al, ; Manthou et al, ; Sohrab et al, ; Stockton et al, ; Sumner et al, ; Wu et al, ); however, sex composition of participants was not mentioned in two studies (González‐Ortiz et al, ; Hosseini et al, ). The interventions were diverse and could be categorized into pomegranate juice (PJ), which used in nine trials (Ekhlasi et al, ; Fuster‐Muñoz et al, ; González‐Ortiz et al, ; Kojadinovic et al, ; Lynn et al, ; Manthou et al, ; Sadegh Eghbali et al, ;Sohrab et al, ; Sumner et al, ); pomegranate extracts (PE), which used in three studies (Hosseini et al, ; Stockton et al, ; Wu et al, ); and pomegranate vinegar (PV), which was used in one study (Park et al, ). All studies except one study (Sohrab et al, ) did not consider energy adjustment of dietary intake and only supplemented pomegranate in addition to diet in participants.…”

“…Only 4 of 13 included studies explained how the subjects were randomized, such as internet random number generator website (Stockton et al, ), block randomization (Hosseini et al, ; Lynn et al, ), and computer generated random numbers (Park et al, ), whereas other trials did not mention randomization procedure (Ekhlasi et al, ; Fuster‐Muñoz et al, ; González‐Ortiz et al, ; Kojadinovic et al, ; Manthou et al, ; Sadegh Eghbali et al, ; Sohrab et al, ; Sumner et al, ; Wu et al, ). Moreover, eight studies (Fuster‐Muñoz et al, ; González‐Ortiz et al, ; Hosseini et al, ; Park et al, ; Sohrab et al, ; Stockton et al, ; Sumner et al, ; Wu et al, ) reported double blinding, but most of them did not explain the method of blinding. Five studies described the exact method of allocation concealment (Hosseini et al, ; Park et al, ; Sohrab et al, ; Stockton et al, ; Sumner et al, ).…”