Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms

Crateva adansonii DC, an African ethnomedicinal plant, exerts cytotoxicity in vitro and prevents experimental mammary tumorigenesis in vivo

“…Increasingly, various medicinal plants are being screened for anticancer properties and may provide effective therapeutic agents. Numerous phytoconstituents against breast tumour cells are well documented as well as those preventing the occurrence of mammary tumours in various experimental animal models via modulation of proliferation, differentiation, apoptosis, oxidative stress, inflammation, angiogenesis and several cell signalling pathways involved in breast cancer (Sinha et al, 2012;Reuben et al, 2012;Vadodkar et al, 2012;Parikh et al, 2014;Siddiqui et al, 2015;Magne Nde et al, 2015;Sinha et al, 2016).…”

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

“…According to published literature reports, RSV naturally exists as two isomers, cis and trans, which feature absorbance peaks at 280 nm and 304 nm, respectively. 28 The trans-isomer exhibits higher bioactivity and proves to be more stable than the cis-isomer. Furthermore, the cis-isomer is known to be easily formed from the trans-isomer via heat induction.…”

“…For instance, the change from trans-isomer to cis-isomer can reduce the biological activity of RSV significantly. [27][28][29] Therefore, various new strategies, including encapsulation of RSV into lipid or polymer-based nanoparticles, delivery using carbon nanomaterials and so on, have been developed in an effort to protect the structural integrity of the bioactive molecule. [29][30][31] And these carriers showed high RSV loading capacity, enabling their use in biomedical applications.…”

Lycorine inhibits MDA-MB-231 breast cancer cell proliferation, migration and invasion that are associated with Wnt/β-catenin signaling

“…In the past several decades, natural compounds such as resveratrol (Sinha et al, 2016), epigallocatechin-3-gallate, oldenlandia diffusa and Ziziphus jujube have been demonstrated that possessed potential anti-breast cancer activity (Bonofiglio et al, 2016).…”

“…In the treatment for breast cancer, some adverse effects could cause serious complications and affect the health and quality of life among survivors (Odle, 2014). Therefore, it is necessary to develop novel anti-cancer candidates for breast cancer.In the past several decades, natural compounds such as resveratrol (Sinha et al, 2016), epigallocatechin-3-gallate, oldenlandia diffusa and Ziziphus jujube have been demonstrated that possessed potential anti-breast cancer activity (Bonofiglio et al, 2016).Lycorine, known as a multifunctional compound, is extensively studied for its pharmacological activities, such as anti-tumor activity (Lamoral-Theys et al, 2010). Previous studies have shown that lycorine presented a potential anti-cancer activity in breast cancer via the inhibition of tumor growth and metastasis Ying et al, 2017).…”