Benefits of Physical Exercise for Individuals with Fragile X Syndrome in Humans

Lee, Minkyung; Won, Jinyoung; Lee, Seonghoon; Hong, Yunkyung; Kim, Jooheon; Hong, Yonggeun

doi:10.15280/jlm.2015.5.2.35

Cited by 6 publications

(4 citation statements)

References 33 publications

(34 reference statements)

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“…Occupational and physical therapy can enhance fine motor skills, sensory processing, and activities of daily living. 18,19 Mindfulness meditation techniques, which may reduce overall psychological symptomatology by emphasizing detached observation and heightened awareness of consciousness content, can serve as a potent cognitive behavioral coping strategy. 20 Cognitive behavioral therapy can contribute to high functioning in individuals with FXS by dealing with anxiety, ADHD, social challenges, and depression using individualized therapy.…”

Section: Non-ph a R M Acologica L I N Terv E N Tions I N F X Smentioning

confidence: 99%

“…They can help address challenging behaviors, improve communication skills and language development, and teach social and adaptive skills. Occupational and physical therapy can enhance fine motor skills, sensory processing, and activities of daily living 18, 19 . Mindfulness meditation techniques, which may reduce overall psychological symptomatology by emphasizing detached observation and heightened awareness of consciousness content, can serve as a potent cognitive behavioral coping strategy 20 .…”

Section: Non‐pharmacological Interventions In Fxsmentioning

confidence: 99%

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State‐of‐the‐art therapies for fragile X syndrome

Protic,

Hagerman

2024

Develop Med Child Neuro

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Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a full mutation (> 200 CGG repeats) in the FMR1 gene. FXS is the leading cause of inherited intellectual disabilities and the most commonly known genetic cause of autism spectrum disorder. Children with FXS experience behavioral and sleep problems, anxiety, inattention, learning difficulties, and speech and language delays. There are no approved medications for FXS; however, there are several interventions and treatments aimed at managing the symptoms and improving the quality of life of individuals with FXS. A combination of non‐pharmacological therapies and pharmacotherapy is currently the most effective treatment for FXS. Currently, several targeted treatments, such as metformin, sertraline, and cannabidiol, can be used by clinicians to treat FXS. Gene therapy is rapidly developing and holds potential as a prospective treatment option. Soon its efficacy and safety in patients with FXS will be demonstrated.

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Section: Non-ph a R M Acologica L I N Terv E N Tions I N F X Smentioning

confidence: 99%

Section: Non‐pharmacological Interventions In Fxsmentioning

confidence: 99%

State‐of‐the‐art therapies for fragile X syndrome

Protic,

Hagerman

2024

Develop Med Child Neuro

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“…Exercise has been shown to be beneficial for children with FXS and ASD [86]. In neurodevelopmental children, physical activity is associated with improved attention and cognitive control [87].…”

Section: Non-pharmacological Therapy Of Fxsmentioning

confidence: 99%

Fragile X Syndrome: From Molecular Aspect to Clinical Treatment

Protić

Aishworiya

Salcedo-Arellano

et al. 2022

IJMS

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Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the full mutation as well as highly localized methylation of the fragile X mental retardation 1 (FMR1) gene on the long arm of the X chromosome. Children with FXS are commonly co-diagnosed with Autism Spectrum Disorder, attention and learning problems, anxiety, aggressive behavior and sleep disorder, and early interventions have improved many behavior symptoms associated with FXS. In this review, we performed a literature search of original and review articles data of clinical trials and book chapters using MEDLINE (1990–2021) and ClinicalTrials.gov. While we have reviewed the biological importance of the fragile X mental retardation protein (FMRP), the FXS phenotype, and current diagnosis techniques, the emphasis of this review is on clinical interventions. Early non-pharmacological interventions in combination with pharmacotherapy and targeted treatments aiming to reverse dysregulated brain pathways are the mainstream of treatment in FXS. Overall, early diagnosis and interventions are fundamental to achieve optimal clinical outcomes in FXS.

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“…In addition, one of the factors that exacerbates a number of health problems, including menopause-related problems themselves, is physical inactivity. Physical exercise has been shown to be one of the non-pharmacological interventions with the most benefits for mental and physical health in older adults and postmenopausal women [26][27][28][29][30][31][32][33][34][35]. In addition, it also has an important role in the prevention of cognitive decline because it induces functional and structural variations in the brain that provide important biological and psychological benefits [7,[36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Healthy Aging in Menopause: Prevention of Cognitive Decline, Depression and Dementia through Physical Exercise

Guerrero-González,

Cueto-Ureña,

Cantón-Habas

et al. 2024

Physiologia

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The aging of the global population is a significant and complex phenomenon with far-reaching implications for healthcare systems and society. By 2030, it is projected that the number of individuals over the age of 65 will increase by nearly 1 billion, largely due to advancements in healthcare and improvements in quality of life. Aging is a multifaceted process that encompasses a wide array of changes, spanning from the cellular level to the intricate physiological systems of the human body. At the central nervous system level, aging represents a major risk factor for conditions such as depression and cognitive impairment, which are likely linked to neuroinflammatory processes and can potentially lead to more severe dementias, including Alzheimer’s disease (AD). The higher prevalence of AD in women compared to men has led to speculation that the onset of menopause and associated phenomena, particularly the decline in estrogen levels, may play a role in the development of the disease. Furthermore, research has shown that physical exercise confers both physical and mental health benefits to older adults, with women potentially experiencing the greatest advantages. Understanding the multifaceted nature of aging and its implications for health will ensure that older adults receive the support and care essential for maintaining their health and quality of life.

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Benefits of Physical Exercise for Individuals with Fragile X Syndrome in Humans

Cited by 6 publications

References 33 publications

State‐of‐the‐art therapies for fragile X syndrome

State‐of‐the‐art therapies for fragile X syndrome

Fragile X Syndrome: From Molecular Aspect to Clinical Treatment

Healthy Aging in Menopause: Prevention of Cognitive Decline, Depression and Dementia through Physical Exercise

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