Thiol/disulfide homeostasis in predicting adverse perinatal outcomes at 24–28 weeks of pregnancy in gestational diabetes

Abstract

GDM patients, with decreased native thiol levels at 24-28 weeks of pregnancy and with higher pre-pregnancy BMI, have an increased risk of possible adverse perinatal outcomes. Also, increased 1-h and 2-h glucose levels on 100 g OGTT can predict the need for insulin treatment for GDM.

Thiol-disulphide homeostasis is an oxidative stress indicator in critically ill children with sepsis

“…The role of antioxidants in sepsis is based on limited number of studies conducted on adults. 8,9 Although thiol levels as an antioxidant parameter have been previously reported in other diseases, [16][17][18] our current study is the first one investigating the dynamic thiol/disulphide homeostasis in children with sepsis. In this study, we aimed to determine the levels of dynamic thiol/disulphide homeostasis in paediatric patients with sepsis and to explore their effects on the prognosis.…”

La homeostasis de tiol/disulfuro es un indicador del estrés oxidativo en los niños críticamente enfermos con sepsi

“…La función de los antioxidantes en la sepsis se basa en una cantidad limitada de estudios realizados en adultos. 8,9 Si bien se notificó previamente el uso de las concentraciones de tioles como parámetro antioxidante en otras enfermedades, [16][17][18] este es el primer estudio que investigó la homeostasis dinámica de tiol/disulfuro en niños con sepsis. La homeostasis dinámica de tiol/disulfuro tiene una función esencial en la protección antioxidante como marcador novedoso del estrés oxidativo que, cada vez más, está implicado en muchos trastornos; su determinación brinda información valiosa sobre varios procesos bioquímicos normales o anormales.…”

The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

“…An overproduction of oxidized thiolated proteins signifies oxidative stress [8,20]. Alterations to thiol-based redox systems therefore modulate several pathways and are associated with various diseases [9][10][11][12][13][14].…”

“…Regulation of the thiol-disulfide network is closely related to the alteration of cellular responses [8]. Therefore, thiol-disulfide status has been linked to a growing number of disease pathophysiologies [10][11][12][13][14].…”