Thymic Epithelial Tumor-Associated Cytopenia: A 10-Year Observational Study in France

Abstract

The optimal treatment for TET-associated cytopenia has not been clearly defined and the outcome does not appear to be correlated with TET progression. For GS, prophylactic immunoglobulin replacement therapy and prophylactic antibiotic therapy can be recommended.

Aplastic Anemia and Good Syndrome in a Heavily Treated Stage IV Thymoma Patient: A Case Report and Review of the Literature

“…The combination of lymphopenia and hypogammaglobulinemia typical of GS, coupled to the neutropenia, caused by bone marrow failure, was the main predisposing factor for the poor outcome of our patient [25].…”

Moving Immune Checkpoint Blockade in Thoracic Tumors beyond NSCLC

“…TETs may be accompanied by paraneoplastic syndromes, most commonly myasthenia gravis, arising in approximately 30% of patients. 114 The neuromuscular system may be affected, while CNS, hematologic (mainly pure red cell aplasia and Good's syndrome), 115 suffering from thymic carcinoma was affected by myasthenia gravis too. 118 The physiopathology of this indication involves alterations in T cell maturation, leading to autoimmune disorders.…”

A case of immune thrombocytopenia associated with invasive thymoma successfully treated with eltrombopag

“…As such, benign or malignant tumors originating from the thymus can lead to loss of self-tolerance and development of autoimmunity [1]. The most common autoimmune disease associated with thymic tumor is myasthenia gravis, followed by pure red cell aplasia (PRCA) [2]. There are reports of other types of immune cytopenias including immune thrombocytopenia [3] and acquired amegakaryocytic thrombocytopenia (AAMT) [4], but because of their rare incidence, the treatment is not well defined.…”

“…Several mechanisms can cause thrombocytopenia in thymoma, such as 1) secondary to aplastic anemia [8]; 2) immune thrombocytopenia [39]; and 3) acquired amegakaryocytic thrombocytopenia [4]. As immune thrombocytopenia seems to be a rare occurrence in this context [2], there is a lack of a standard treatment for this potentially life-threatening condition.…”

“…In previously reported cases of thymoma-associated immune thrombocytopenia, all patients were apt for thymectomy [239] and thrombocytopenia was improved after surgery. Unfortunately, in this case, the mediastinal mass was encasing the large vessels (Fig.…”