Abstract:Clinical yeast isolates belonging to Candida pelliculosa, Candida utilis and Candida fabianii are difficult to distinguish in a routine mycology laboratory using common biochemical tests. The aims of this study were to determine the prevalence of C. pelliculosa, C. utilis and C. fabianii in clinical samples and to compare their minimum inhibitory concentrations (MICs) to systemic antifungals. Two hundred and forty-eight clinical yeast isolates obtained from eight large hospitals in the Czech Republic were incl… Show more
“…In a recent survey of Czech hospitals, Cy. fabianii has emerged as a significant yeast with the same frequency as Candida lusitaniae and Candida guilliermondii [1]. In addition, Hof et al [16] reported that neonates are relatively prone to the infection by Cy.…”
Section: Discussionmentioning
confidence: 99%
“…Bhally et al [17] also reported that API 20 C did not identify the yeast. In addition, Svobodova et al [1] mentioned that morphological identification and common biochemical kits cannot distinguish non-albicans clinical isolates such as C. pelliculosa, Cy. jadinii (previously C. utilis), and Cy.…”
Section: Discussionmentioning
confidence: 99%
“…NAC species as well as Candida albicans can infect a broad range of body sites as opportunistic pathogens. With the increase in the number of patients showing acquired immune deficiency syndrome, the fungal infections caused by NAC species have been reported with a higher incidence rate [1]. Cyberlindnera fabianii (basionym Hansenula fabianii), one of the NAC species, is known as a rare cause of invasive human infection.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, the case reports of fungal infections caused by Cy. fabianii in blood and urine have increased worldwide such as in China, Croatia, India, Czech and South Korea [1,[3][4][5].…”
Invasive fungal infections caused by Cyberlindnera fabianii have recently increased. However, biochemical kits such as API 20 C AUX and Vitek-2C have misidentified this species as other Candida spp. such as C. pelliculosa or C. utilis due to no information of Cy. fabianii in yeast database. During our 2016-2017 surveys, eleven isolates of Cy. fabianii were obtained in International St. Mary's Hospital in Korea. Here, we describe its morphological and molecular characteristics and tested its antifungal susceptibility against nine antifungal agents. The sequences of the ITS region and the D1/D2 region of LSU revealed 100% identity with the sequences of Cy. fabianii. In comparison with the results from MALDI-TOF mass spectrometry, we found that Cy. fabianii can be distinguished from other species. In antifungal susceptibility test, voriconazole and echinocandins exhibited good antifungal activities against the majority of Cy. fabianii isolates despite the absence of standard criteria.
“…In a recent survey of Czech hospitals, Cy. fabianii has emerged as a significant yeast with the same frequency as Candida lusitaniae and Candida guilliermondii [1]. In addition, Hof et al [16] reported that neonates are relatively prone to the infection by Cy.…”
Section: Discussionmentioning
confidence: 99%
“…Bhally et al [17] also reported that API 20 C did not identify the yeast. In addition, Svobodova et al [1] mentioned that morphological identification and common biochemical kits cannot distinguish non-albicans clinical isolates such as C. pelliculosa, Cy. jadinii (previously C. utilis), and Cy.…”
Section: Discussionmentioning
confidence: 99%
“…NAC species as well as Candida albicans can infect a broad range of body sites as opportunistic pathogens. With the increase in the number of patients showing acquired immune deficiency syndrome, the fungal infections caused by NAC species have been reported with a higher incidence rate [1]. Cyberlindnera fabianii (basionym Hansenula fabianii), one of the NAC species, is known as a rare cause of invasive human infection.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, the case reports of fungal infections caused by Cy. fabianii in blood and urine have increased worldwide such as in China, Croatia, India, Czech and South Korea [1,[3][4][5].…”
Invasive fungal infections caused by Cyberlindnera fabianii have recently increased. However, biochemical kits such as API 20 C AUX and Vitek-2C have misidentified this species as other Candida spp. such as C. pelliculosa or C. utilis due to no information of Cy. fabianii in yeast database. During our 2016-2017 surveys, eleven isolates of Cy. fabianii were obtained in International St. Mary's Hospital in Korea. Here, we describe its morphological and molecular characteristics and tested its antifungal susceptibility against nine antifungal agents. The sequences of the ITS region and the D1/D2 region of LSU revealed 100% identity with the sequences of Cy. fabianii. In comparison with the results from MALDI-TOF mass spectrometry, we found that Cy. fabianii can be distinguished from other species. In antifungal susceptibility test, voriconazole and echinocandins exhibited good antifungal activities against the majority of Cy. fabianii isolates despite the absence of standard criteria.
“…Svobodova et al. () compared biochemical identification of clinical yeast isolates to Wickerhamomyces anomalus / Candida pelliculosa and L. jadinii / C. utilis , with MALDI‐TOF MS identification of the same isolates. The MALDI‐TOF, identified the majority of the isolates as Candida fabianii , a non‐QPS species.…”
EFSA is requested to assess the safety of a broad range of biological agents in the context of notification for market authorisation as sources of food and feed additives, food enzymes and plant protection products. The qualified presumption of safety (QPS) assessment was developed to provide a harmonised generic preassessment to support safety risk assessments performed by EFSA's scientific Panels. The safety of unambiguously defined biological agents (at the highest taxonomic unit appropriate for the purpose for which an application is intended), and the completeness of the body of knowledge are assessed. Identified safety concerns for a taxonomic unit are, where possible and reasonable in number, reflected as 'qualifications' in connection with a recommendation for a QPS status. The list of QPS recommended biological agents was reviewed and updated in the current opinion and therefore becomes the valid list. The 2016 update reviews previously assessed microorganisms including bacteria, yeasts and viruses used for plant protection purposes following an Extensive Literature Search strategy. The taxonomic units related to the new notifications received since the 2013 QPS opinion, were periodically evaluated for a QPS status and the results published as Statements of the BIOHAZ Panel. Carnobacterium divergens, Lactobacillus diolivorans, Microbacterium imperiale, Pasteuria nishizawae, Pediococcus parvulus, Bacillus flexus, Bacillus smithii, Xanthomonas campestris and Candida cylindracea were recommended for the QPS list. All taxonomic units previously recommended for the 2013 QPS list had their status reconfirmed as well their qualifications with the exception of Pasteuria nishizawae for which the qualification was removed. The exclusion of filamentous fungi and enterococci from the QPS evaluations was reconsidered but monitoring will be maintained and the status will be re-evaluated in the next QPS Opinion update. Evaluation of bacteriophages should remain as a case-by-case procedure and should not be considered for QPS status. Acknowledgements: The BIOHAZ Panel wishes to thank the EFSA staff member: Mirena Ivanova for the support provided to this scientific output.
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