Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo in humans: a randomized trial

Luttikhold, Joanna; Norren, Klaske van; Rijna, Herman; Buijs, Nikki; Ankersmit, Marjolein; Heijboer, Annemieke C.; Gootjes, Jeannette; Hartmann, Bolette; Holst, Jens J.; Loon, Luc J. C. van; Leeuwen, Paul A. M. van

doi:10.3945/ajcn.115.116251

Cited by 17 publications

(17 citation statements)

References 31 publications

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“…Since it is hypothesised that calcium citrate should be absorbed in the intestine more proximally than calcium phosphate (and thus provide calcium to proximal versus distal components of the intestine), the sample size for study 1 was determined using plasma iAUC for GLP-1 7-36 (in the absence of relevant data on GLP-1 Total ) in response to jejunal vs gastric feeding of mixed-macronutrients [28]. Jejunal vs gastric feeding produces a plasma GLP-1 7-36 iAUC of 2.0 ± 1.4 vs 1.0 ± 1.3 mol L −1 × 720 min, respectively.…”

Section: Study 1: Calcitr Versus Milk Minerals Versus Milk Minerals +mentioning

confidence: 99%

Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

et al. 2019

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Purpose To examine whether calcium type and co-ingestion with protein alter gut hormone availability. Methods Healthy adults aged 26 ± 7 years (mean ± SD) completed three randomized, double-blind, crossover studies. In all studies, arterialized blood was sampled postprandially over 120 min to determine GLP-1, GIP and PYY responses, alongside appetite ratings, energy expenditure and blood pressure. In study 1 (n = 20), three treatments matched for total calcium content (1058 mg) were compared: calcium citrate (CALCITR); milk minerals rich in calcium (MILK MINERALS); and milk minerals rich in calcium plus co-ingestion of 50 g whey protein hydrolysate (MILK MINERALS + PROTEIN). In study 2 (n = 6), 50 g whey protein hydrolysate (PROTEIN) was compared to MILK MINERALS + PROTEIN. In study 3 (n = 6), MILK MINERALS was compared to the vehicle of ingestion (water plus sucralose; CONTROL). Results MILK MINERALS + PROTEIN increased GLP-1 incremental area under the curve (iAUC) by ~ ninefold (43.7 ± 11.1 pmol L −1 120 min; p < 0.001) versus both CALCITR and MILK MINERALS, with no difference detected between CALCITR (6.6 ± 3.7 pmol L −1 120 min) and MILK MINERALS (5.3 ± 3.5 pmol L −1 120 min; p > 0.999). MILK MINERALS + PROTEIN produced a GLP-1 iAUC ~ 25% greater than PROTEIN (p = 0.024; mean difference: 9.1 ± 6.9 pmol L −1 120 min), whereas the difference between MILK MINERALS versus CONTROL was small and nonsignificant (p = 0.098; mean difference: 4.2 ± 5.

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Section: Study 1: Calcitr Versus Milk Minerals Versus Milk Minerals +mentioning

confidence: 99%

Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

et al. 2019

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“…In healthy young men, EN with JF showed a similar result. JF resulted in substantially higher peak plasma PYY, GLP‐1, and GLP‐2 concentrations compared with GF, which would lead to delayed gastric emptying . Meanwhile, JF would cause the ileal brake, which was activated by the release of PYY and GLP‐1.…”

Section: Discussionmentioning

confidence: 99%

“…JF resulted in substantially higher peak plasma PYY, GLP-1, and GLP-2 concentrations compared with GF, which would lead to delayed gastric emptying. 30 Meanwhile, JF would cause the ileal brake, which was activated by the release of PYY and GLP-1. Most effects of PYY and GLP-1 are inhibitory, such as the inhibition of gastric, pancreatic, and intestinal secretion or reductions in gastrointestinal motility, gallbladder emptying, and gastric emptying, which leads to reduced digestion and absorption of nutrients.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Gastric and Jejunal Feeding in Hypercatabolism Associated With Hypothalamic AMPK‐Autophagy‐POMC in Endotoxemic Rats

Cao

Li²,

Yang

et al. 2019

J Parenter Enteral Nutr

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Background Hypercatabolism is associated with increased infectious rates and mortality in critically ill patients. Enteral nutrition (EN) is usually used to counteract hypercatabolism. However, the impact of different routes of EN on hypercatabolism remains unknown. Here, we compared the impact of gastric feeding (GF) and jejunal feeding (JF) on gastrointestinal hormones and hypercatabolism, which is associated with hypothalamic adenosine 5′‐monophosphate‐activated protein kinase (AMPK)‐autophagy‐proopiomelanocortin (POMC). Methods Sixty adult male Sprague‐Dawley rats were divided into 5 groups: Sham and lipopolysaccharide (LPS) groups fed a standard chow diet, a pair‐fed group that was a subset of saline‐treated rats pair‐fed with the LPS group, and LPS + JF and LPS + GF groups (received EN via jejunal and gastric tube, respectively, for 3 days [100 kcal/kg/d]). Hypercatabolism was measured by insulin resistance, muscle protein synthesis, and atrophy. Serum gastrointestinal hormones, hypothalamic ghrelin, growth hormone secretagogue receptor‐1α (GHS‐R1α), and AMPK‐autophagy‐POMC markers were also detected. Results GF increased serum total, acylated, desacylated, and hypothalamic ghrelin and decreased glucagon‐like peptide‐1 (GLP‐1). But no effect on pancreatic polypeptide (PYY) and hypothalamic GHS‐R1α was observed. JF showed no effect on hypothalamic ghrelin, GHS‐R1α, and serum total, acylated, and desacylated ghrelin and even further aggravated GLP‐1 and PYY. GF could effectively augment hypothalamic AMPK‐autophagy‐POMC and hypercatabolism. However, JF showed no effect on hypothalamic AMPK‐autophagy‐POMC and hypercatabolism. Conclusions GF could activate hypothalamic AMPK‐autophagy and suppress POMC expression via gastrointestinal hormones to ameliorate hypercatabolism compared with JF, which suggested that GF may be the preferred route of EN in endotoxemic rats.

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“…Это особенно важно для больных с ОРДС на ИВЛ, так как микроаспирации вследствие нарушения пассажа химу- Науковий огляд / Scientific Review са или нарушения технологии энтерального питания сопряжены с возникновением аспирационных пневмоний и ухудшением респираторной функции. Сывороточные и растительные белки -это «быстрые» некоагулируемые белки, которые быстрее перевариваются и усваиваются, чем казеин, как «медленный» белок [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: положение на животеunclassified

“…Если предположить, что пациенты получали полноценное питание до того, как заразились SARS-CoV-2, и острая фаза болезни была ограниченна, общие рекомендации по вопросам обеспечения питанием для ОРИТ от этих обществ являются достаточными. Было доказано, что большинство пациентов с сепсисом или циркуляторным шоком переносят раннее ЭП с трофической скоростью [4]. Если не наблюдается увеличение дозы сосудосуживающих средств в сочетании с непереносимостью энтерального питания с симптомами непроходимости (абдоминальная недостаточность, рвота), COVID-19 с шоком не следует рассматривать как противопоказание к трофическому ЭП [4].…”

Section: рекомендация 2 начало нутритивной терапииunclassified

Обзор Международных Рекомендаций По Нутритивной Поддержке У Больных С COVID-19, Находящихся В Отделении Интенсивной Терапии

Kobelyatskyi¹

2021

ЕМ

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Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo in humans: a randomized trial

Cited by 17 publications

References 31 publications

Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

A Comparison of Gastric and Jejunal Feeding in Hypercatabolism Associated With Hypothalamic AMPK‐Autophagy‐POMC in Endotoxemic Rats

Обзор Международных Рекомендаций По Нутритивной Поддержке У Больных С COVID-19, Находящихся В Отделении Интенсивной Терапии

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