“…In addition, the effect of the 5XFAD transgene significantly altered the expression of genes known to be misregulated in AD, particularly Bin1, Cd33, Clu (Karch et al, 2012), Trem2 (Piccio et al, 2016), and C1qa (Hong et al, 2016), Figure 1F. However, the impact of causal FAD mutations on cognitive performance and risk gene expression varied widely depending on the specific background strain evaluated.…”