Combined multimodal co-registration of PET/CT and MRI images increases diagnostic accuracy in squamous cell carcinoma staging

Stecco, Alessandro; Ciolfi, Silvio; Buemi, Francesco; Cassarà, Alessia; Sacchetti, Gian Mauro; Brambilla, Marco; Carriero, Alessandro

doi:10.1007/s11547-015-0617-y

Cited by 5 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Schouten et al [ 34 ] performed a retrospective study on a cohort of 84 patients histologically diagnosed with advanced stage HNSCC; after 3 months of CRT, these patients were subjected to DW-MRI and 18FDG-PET/CT examinations. Stecco et al [ 38 ] performed a retrospective study on a cohort of 25 patients with HNSCC who had undergone MRI and PET/CT scans before treatment; the authors assessed the sensitivity, specificity, positive and negative predictive values of PET/CT, MRI, and their combined use in T and N staging. Jin et al [ 39 ] performed a study on a cohort of patients affected by NPC to evaluate the efficacy of DW-MRI in assessing the benign or malignant nature of cervical LNs smaller than 10 mm: all of the patients underwent a DW-MRI scan using a 1.5T device; after no more than 2 weeks an US-guided FNA biopsy (FNAB) was performed on selected LNs.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Diffusion-weighted imaging and apparent diffusion coefficient mapping of head and neck lymph node metastasis: a systematic review

Belfiore

Nardone

D’Onofrio³

et al. 2022

Exploration of Targeted Anti-Tumor Therapy

View full text Add to dashboard Cite

Aim: Head and neck squamous cell cancer (HNSCC) is the ninth most common tumor worldwide. Neck lymph node (LN) status is the major indicator of prognosis in all head and neck cancers, and the early detection of LN involvement is crucial in terms of therapy and prognosis. Diffusion-weighted imaging (DWI) is a non-invasive imaging technique used in magnetic resonance imaging (MRI) to characterize tissues based on the displacement motion of water molecules. This review aims to provide an overview of the current literature concerning quantitative diffusion imaging for LN staging in patients with HNSCC. Methods: This systematic review performed a literature search on the PubMed database (https://pubmed.ncbi.nlm.nih.gov/) for all relevant, peer-reviewed literature on the subject following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) criteria, using the keywords: DWI, MRI, head and neck, staging, lymph node. Results: After excluding reviews, meta-analyses, case reports, and bibliometric studies, 18 relevant papers out of the 567 retrieved were selected for analysis. Conclusions: DWI improves the diagnosis, treatment planning, treatment response evaluation, and overall management of patients affected by HNSCC. More robust data to clarify the role of apparent diffusion coefficient (ADC) and DWI parameters are needed to develop models for prognosis and prediction in HNSCC cancer using MRI.

show abstract

Section: Resultsmentioning

confidence: 99%

“…MRI characteristics of the included studies. Among the 18 relevant papers, the b-values used in the studies we reviewed were b0-1000 [12,16,[28][29][30][31], b500-1000 [32][33][34][35], b0-800 [36][37][38][39][40], b250-1000 [41], and b0-1500 [42,43]. In Table 1 protocols, machines, and standard references used are shown.…”

Section: Resultsmentioning

confidence: 99%

Diffusion-weighted imaging and apparent diffusion coefficient mapping of head and neck lymph node metastasis: a systematic review

Belfiore

Nardone

D’Onofrio³

et al. 2022

Exploration of Targeted Anti-Tumor Therapy

View full text Add to dashboard Cite

show abstract

“…A few comparative studies of the head and neck cancer have shown relatively slight differences between diffusion-weighted MRI, PET/CT, and PET/MRI imaging in the initial staging examination. 43 – 45 …”

Section: Imagingmentioning

confidence: 99%

Merkel Cell Carcinoma of the Head and Neck: Recommendations for Diagnostics and Treatment

et al. 2017

View full text Add to dashboard Cite

BackgroundMerkel cell carcinoma (MCC) is a rare, aggressive tumor that often occurs in the head and neck region. Because of these features, the classifications and diagnostic and treatment regimens are frequently modified. Especially in the anatomically complex head and neck region, it is crucial to be aware of the current recommendations for diagnostics and treatment of MCC to ensure appropriate treatment. This overview aims to summarize the currently available literature.MethodsThe authors reviewed the relevant literature and international guidelines for MCC from 2012 to 2017 with respect to epidemiology and prognosis, diagnostic procedures and imaging, surgery, radiation, systemic treatment, and aftercare. These results were compared with existing guidelines, some of them current, and recommendations were derived.ResultsMarked developments in imaging have resulted in an increased use of functional imaging. The surgical concepts have changed regarding safety margins and the use of sentinel node biopsies. In systemic treatment, a move from conventional agents toward immuno-oncology can be observed.ConclusionsFor staging, it is important to be as exact as possible using functional imaging (e.g., positron emission tomography/computed tomography scan), especially in the head and neck area with its complex lymph drainage. This often plays an especially important role in early stages of the tumor, when the resection margin can be reduced to preserve the organ. Aftercare also should include functional imaging. In an advanced, metastatic stage, immuno-oncology (PD-1, PD-L1, CTLA-4) is superior to the previous methods of systemic treatment.

show abstract

“…However, 18 F FDG PET/CT remains limited by a high false-positive rate, that especially occurs when 18 F FDG PET/CT scans are obtained earlier than 8-12 weeks after treatment or when treatment-related inflammation is a confounding factor [13,14]. Other studies correlated DWI-and 18 F-FDG-PET/CTparameters to a predictive value for treatment failure, locoregional recurrence and death [15]; or concluded that combined MR-PET-CT analysis have more accurate results for trans-compartmental extensions in T and N staging [16,17]. Qualitative analysis of 18 F-FDG-PET/CT is a stronger predictor of recurrence-free survival than DWI analysis [18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of diffusion-weighted MR imaging and 18F Fluorodeoxyglucose PET/CT in detection of residual or recurrent tumors and delineation of their local spread after (chemo) radiotherapy for head and neck squamous cell carcinoma

Schroeder

Lee

Tetzner

et al. 2020

European Journal of Radiology

View full text Add to dashboard Cite

To compare the diagnostic accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) and fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in detection of residual or recurrent tumors and their local extension in patients with head and neck squamous cell carcinoma after treatment with (chemo) radiotherapy (CRT). Method: Twenty-five patients (17 men, 8 women, median age 64 years, range 49-79) who underwent surgical salvage for residual or recurrent tumors after CRT were included. The histopathologic analysis after the surgical salvage served as the gold standard. Results: Both DW-MRI and 18 F-FDG PET/CT had a sensitivity of 92 % (23/25) in the detection of residual or recurrent tumors. MRI had a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting perineural spread of 62 % (5/8), 88 % (15/17), 71 % (5/7) and 83 % (15/18), respectively; in comparison, PET/CT did not detect any cases of perineural spread. The sensitivity, specificity, PPV and NPV of MRI in detecting muscle infiltration was 75 % (9/12), 77 % (10/13), 75 % (9/12) and 77 % (10/13) respectively, while the values for 18 F-FDG PET/CT were 58 % (7/12), 69 % (9/13), 64 % (7/11) and 64 % (9/14). Conclusions: DW-MRI-and 18 F-FDG PET/CT-imaging have an identical detection rate of residual or recurrent tumors after (chemo) radiotherapy. MRI has a higher sensitivity in detecting local perineural spread, has a better accuracy in the detection of muscle infiltration and more accurately correlates the lesion size to the histopathologic specimen.

show abstract

Combined multimodal co-registration of PET/CT and MRI images increases diagnostic accuracy in squamous cell carcinoma staging

Abstract: Multi-modal imaging assessment of co-registered MRI and PET/CT images provides more accurate results for trans-compartmental extensions in T and N staging than the individual techniques alone.

Cited by 5 publications

References 25 publications

Diffusion-weighted imaging and apparent diffusion coefficient mapping of head and neck lymph node metastasis: a systematic review

Diffusion-weighted imaging and apparent diffusion coefficient mapping of head and neck lymph node metastasis: a systematic review

Merkel Cell Carcinoma of the Head and Neck: Recommendations for Diagnostics and Treatment

Comparison of diffusion-weighted MR imaging and 18F Fluorodeoxyglucose PET/CT in detection of residual or recurrent tumors and delineation of their local spread after (chemo) radiotherapy for head and neck squamous cell carcinoma

Contact Info

Product

Resources

About