The status of glycation in protein aggregation

Taghavi, Fereshteh; Habibi-Rezaei, Mehran; Amani, Mojtaba; Saboury, Ali Akbar; Moosavi-Movahedi, Ali Akbar

doi:10.1016/j.ijbiomac.2015.12.085

Cited by 48 publications

(35 citation statements)

References 89 publications

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“…Among these hallmarks, the “loss of proteostasis” includes protein misfolding and aggregation, in particular amyloid formation, which may be interpreted as resulting from the chemical capability of amino acid residues for other chemical interactions besides those involved in proper folding. Moreover, the chemical modifications of amino acid residues by metabolic intermediates and byproducts may accelerate misfolding in the proteins that otherwise are quite stable (Taghavi et al 2016 ).…”

Section: The Real Definition Of Aging By Genesis Vs Manifestations Of Aging Used In Its Nominal Definitionsmentioning

confidence: 99%

An essay on the nominal vs. real definitions of aging

Golubev

2021

Biogerontology

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In the current literature, the definitions of aging range from relying on certain sets of distinctive features at the molecular, organismal, populational and/or even evolutional levels/scales to declaring it a treatable disease and, moreover, to treating aging as a mental construct rather than a natural phenomenon. One reason of such a mess may be that it is common in the natural sciences to disregard philosophy of science where several categories of definitions are recognized, among which the nominal are less, and the so-called real ones are more appropriate in scientific contexts. E.g., water is, by its nominal definition, a liquid having certain observable features and, by its real definition, a specific combination (or a product of interaction) of hydrogen and oxygen atoms. Noteworthy, the real definition is senseless for people ignorant of atoms. Likewise, the nominal definition of aging as a set of observable features should be supplemented, if not replaced, with its real definition. The latter is suggested here to imply that aging is the product of chemical interactions between the rapidly turning-over free metabolites and the slowly turning-over metabolites incorporated in macromolecules involved in metabolic control. The phenomenon defined in this way emerged concomitantly with metabolic pathways controlled by enzymes coded for by information-storing macromolecules and is inevitable wherever such conditions coincide. Aging research, thus, is concerned with the elucidation of the pathways and mechanisms that link aging defined as above to its hallmarks and manifestations, including those comprised by its nominal definitions. Esoteric as it may seem, defining aging is important for deciding whether aging is what should be declared as the target of interventions aimed at increasing human life and health spans.

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Section: The Real Definition Of Aging By Genesis Vs Manifestations Of Aging Used In Its Nominal Definitionsmentioning

confidence: 99%

An essay on the nominal vs. real definitions of aging

Golubev

2021

Biogerontology

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“…The hyperglycemia-induced AGE activation followed by retinal neovascularization was studied by Shin et al [146]. Glycation process is a toxic cascade reaction in which different oxidative products with high oxidative potential than the parent compound are produced, and their quantity determines its destructiveness [147]. In fact, the toxicity of glycation results in loss of protein function through cross-linking, aggregation and deposition, and production of reactive species, which are an analogy of hypoxia.…”

Section: Protein Glycationmentioning

confidence: 99%

Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders

Adav

2020

Aging and disease

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Aging is an inevitable time-dependent decline of various physiological functions that finally leads to death. Progressive protein damage and aggregation have been proposed as the root cause of imbalance in regulatory processes and risk factors for aging and neurodegenerative diseases. Oxygen is a modulator of aging. The oxygen-deprived conditions (hypoxia) leads to oxidative stress, cellular damage and protein modifications. Despite unambiguous evidence of the critical role of spontaneous non-enzymatic Degenerative Protein Modifications (DPMs) such as oxidation, glycation, carbonylation, carbamylation, and deamidation, that impart deleterious structural and functional protein alterations during aging and age-associated disorders, the mechanism that mediates these modifications is poorly understood. This review summarizes up-to-date information and recent developments that correlate DPMs, aging, hypoxia, and age-associated neurodegenerative diseases. Despite numerous advances in the study of the molecular hallmark of aging, hypoxia, and degenerative protein modifications during aging and age-associated pathologies, a major challenge remains there to dissect the relative contribution of different DPMs in aging (either natural or hypoxia-induced) and age-associated neurodegeneration.

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“…Recently in 2017, Taghavi et al [19] described Maillard reaction, as a series of complex reactions. Despite the advances in science and research related to this subject, Maillard reaction mechanism is not fully known, due to the reactivity and complexity of it.…”

Section: Maillard Reaction Formationmentioning

confidence: 99%

“…In the early twentieth century, there was a very limited knowledge about glycoproteins, these were described as "Compounds of the protein molecule mixed with a substance containing a carbohydrate group that is not a nucleic acid" claiming that glycoproteins were those proteins containing a glycosyl bond [33]. However, years later the term glycation was defined as "All reactions that bind a sugar to a protein or a peptide, whether catalyzed or not by an enzyme" [19]; otherwise Lis and Sharon in 1993 [34] theoretically differentiated the term enzymatic glycosylation and nonenzymatic glycation of sugar-bound proteins.…”

Section: Protein Glycation Via Maillard Reactionmentioning

confidence: 99%

Glycation of Animal Proteins Via Maillard Reaction and Their Bioactivity

Mondaca-Navarro¹,

Ramírez²,

Lerma³

et al. 2020

Food Processing

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Nowadays there has been an increase in the need to incorporate foods in our diets that have optimal and palatable organoleptic characteristics as well as complex interaction in human biological processes that provide beneficial properties to human health. Animal foods and their by-products are an important source of macro-and micronutrients and also a great protein source; nevertheless the consumption of these products has been decreasing since they have been associated with the generation of chronic degenerative diseases; therefore the food industry has sought to innovate toward the generation of healthier foods. This chapter presents an overview of the glycation of proteins of animal origin via the Maillard reaction emphasizing on their posttranslational modifications and their possible uses in food, based on their bioactivity.

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The status of glycation in protein aggregation

Cited by 48 publications

References 89 publications

An essay on the nominal vs. real definitions of aging

An essay on the nominal vs. real definitions of aging

Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders

Glycation of Animal Proteins Via Maillard Reaction and Their Bioactivity

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