Protective effects of Arctium lappa L. root extracts (AREs) on high fat diet induced quail atherosclerosis

Wang, Zhi; Li, Ping; Wang, Chenjing; Jiang, Qixiao; Zhang, Lei; Cao, Yu; Zhong, Weizhen; Wang, Chunbo

doi:10.1186/s12906-016-0987-2

Cited by 21 publications

(19 citation statements)

References 32 publications

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“…HDL is responsible for the transportation of cholesterol to liver, which is essential for cholesterol removal [16]. HDL levels of rat fed with high fat diet for six weeks showed no changes in this study.…”

Section: Discussionmentioning

confidence: 57%

Lowering effects of aspirin eugenol ester on blood lipids in rats with high fat diet

Karam¹,

Liu

et al. 2016

Lipids Health Dis

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BackgroundAspirin and eugenol were esterified to synthesize aspirin eugenol ester (AEE). As a pale yellow and odourless crystal, AEE reduced the gastrointestinal damage of aspirin and vulnerability of eugenol. The study was conducted to evaluate the preventive effects of AEE on blood lipids in rats with high fat diet (HFD).MethodsSuspensions of AEE and simvastatin were prepared in 5% carboxymethyl cellulose sodium (CMC-Na). In order to observe the intervention effects, the drugs and HFD were administrated at the same time. Based on individual weekly body weight (BW), AEE was intragastrically administrated at the dosage of 18, 36 and 54 mg/kg. Simvastatin (10 mg/kg) and CMC-Na (20 mg/kg) were used as control drug. After 6 weeks of administration, the changes of BW and blood lipid indices including triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and total cholesterol (TCH) were determined in the experiment.ResultsThe rat blood lipids profile in model group was remarkably different after feeding 6-weeks HFD. TG, TCH and LDL indexes in model group were increased significantly compared with those in control group (p < 0.01). AEE at the dosage of 54 mg/kg significantly decreased levels of TG, TCH and LDL (p < 0.01), and slowed the rate of BW gain in comparison with model group (p < 0.05). Moreover, high dose AEE showed better effects than simvastatin on reducing TCH level and similar effects on TG, HDL and LDL.ConclusionAEE could remarkably reduce levels of TG, TCH and LDL in rats with high fat diet, and slow the rate of body weight gain. It was conducted that AEE was a potential candidate on reducing blood lipids level. The mechanism of action of AEE should be investigated in further studies.

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Section: Discussionmentioning

confidence: 57%

Lowering effects of aspirin eugenol ester on blood lipids in rats with high fat diet

Karam¹,

Liu

et al. 2016

Lipids Health Dis

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“…Burdock root contains chemical compounds such as inulin, volatile oil, tannin, resin, sugar, iron, calcium, quercetin, arctigenin, and vitamin C (5,6,22,23). However, the mentioned compounds were not recognized using the GC tool in the present study, because all these compounds remained in the extract and they did not penetrate in the solvent.…”

Section: Discussionmentioning

confidence: 65%

“…This can be attributed to the temperature differences in the extracting process and the removal of solvent through rotary. Therefore, the temperature differences can be regarded as the main research for the non-presence of the compounds in the solvent (23).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the qualitative and quantitative improvement of each of these stages can accelerate wound healing and reduce its complications. Furthermore, anti-inflammatory effect is one of several effects of flavonoids in Burdock root (23,26,27). A variety of methods have been proposed to examine the presence of inflammation in damaged tissues.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing

Ghorat

Azizkhani

Naji

et al. 2017

Iran Red Crescent Med J

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Background: Wound healing is a process that occurs following skin lesions. Shortening healing time is of critical importance as it reduces the risk of infection, complications, and costs. Objectives: In this experimental study, 36 male Wistar rats each weighting approximately 200 -220 g were studied in six groups, each with 6 animals for 21 days. Hydroalcoholic extract of Burdock root was prepared through the maceration method. The animals

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“…Aorta lipid profile assessment revealed similar results. Among the different extracts, flavones fraction exerted best protective effects [74].…”

Section: Hypolipidemic Activitymentioning

confidence: 99%

Therapeutic Value of Arctium Lappa Linn. – A Review

Guna¹

2019

Asian J Pharm Clin Res

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Arctium lappa (AL) (Burdock) has been used for centuries to treat a variety of ailments. Extracts of burdock root (BR) are found in a variety of herbal preparations, as well as homeopathic remedies. Arctium has been used as medicine and health supplement for hundreds of years in Europe, North America, and Asia. It is popular as a medicinal plant in traditional Chinese medicine where it is extensively used for various ailments. In recent years, immense phytochemical and pharmacological screening of Arctium has shown tremendous activity against various diseases. The plant has shown biological activity as anti-inflammatory, antiallergic, antidiabetic, antineoplastic, antimutagenic, antiviral, urolytic, antitoxic, antileukemic, hepatoprotective, growth stimulating, mild laxative, mild diuretic, depurative, diaphoretic, antibacterial, antirheumatic, and antipyretic agent. The present review highlights botanical description, distribution, chemical constituents, and the pharmacological effects of AL. The aim of this review is to correlate active principles of the plant to their pharmacological activity and thus explore the potential of AL as a source of therapeutic agents.

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Protective effects of Arctium lappa L. root extracts (AREs) on high fat diet induced quail atherosclerosis

Cited by 21 publications

References 32 publications

Lowering effects of aspirin eugenol ester on blood lipids in rats with high fat diet

Lowering effects of aspirin eugenol ester on blood lipids in rats with high fat diet

Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing

Therapeutic Value of Arctium Lappa Linn. – A Review

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