Erratum to: Gliomatosis cerebri: no evidence for a separate brain tumor entity

Herrlinger, Ulrich; Jones, David; Glas, Martin; Hattingen, Elke; Gramatzki, Dorothee; Stuplich, Moritz; Felsberg, Jörg; Bähr, Oliver; Gielen, Gerrit H.; Simon, Matthias; Wiewrodt, Dorothee; Schabet, Martin; Hovestadt, Volker; Capper, David; Steinbach, Joachim P.; Deimling, Andreas von; Lichter, Peter; Pfister, Stefan M.; Weller, Michael; Reifenberger, Guido

doi:10.1007/s00401-015-1523-z

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“…However, the scientific consensus now is that there is no common pathologic and radiographic consensus for its diagnosis, and in 2016, GC was eliminated from current WHO classification [33]. The reason of the elimination was based on overlap of discrete molecular alterations with other malignant gliomas and the absence of specific molecular markers [34, 35]. Many histomorphological features similar to infiltrative gliomas support the contention that GC is one variety of diffuse glioma including GBM.…”

Section: Gliomatosis Cerebri and Gbmmentioning

confidence: 99%

Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma

Hara

Kanayama

Noguchi

et al. 2019

Journal of Oncology

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Glioblastoma (GBM) is the most common and the most malignant primary brain tumor and is characterized by rapid proliferation, invasion into surrounding normal brain tissues, and consequent aberrant vascularization. In these characteristics of GBM, invasive properties are responsible for its recurrence after various therapies. The histomorphological patterns of glioma cell invasion have often been referred to as the “secondary structures of Scherer.” The “secondary structures of Scherer” can be classified mainly into four histological types as (i) perineuronal satellitosis, (ii) perivascular satellitosis, (iii) subpial spread, and (iv) invasion along the white matter tracts. In order to develop therapeutic interventions to mitigate glioma cell migration, it is important to understand the biological mechanism underlying the formation of these secondary structures. The main focus of this review is to examine new molecular pathways based on the histopathological evidence of GBM invasion as major prognostic factors for the high recurrence rate for GBMs. The histopathology-based pharmacological and biological targets for treatment strategies may improve the management of invasive and resistant GBMs.

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Section: Gliomatosis Cerebri and Gbmmentioning

confidence: 99%