Two new tetracyclic triterpenoids from the barks of <i>Melia azedarach</i>

Ge, Jing‐Yuan; Wang, Lingtian; Chen, Pian; Zhang, Yan; Lei, Xinxiang; Ye, Xiaoxia

doi:10.1080/10286020.2015.1124866

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…It has been known that about 25%–48% of current approved therapies for cancer patients by the FDA (Food and Drug Administration) are derived from plants [5, 6]. According to statistics, hundreds of anticancer agents are either pure natural products, natural product derivatives or synthetic compounds with pharmacophores mimicking natural products [7]. Thus, natural products could be considered as a potential source of new anticancer drugs to combat NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer

et al. 2016

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Rottlerin, a polyphenolic compound derived from Mallotus philipinensis, has been reported to exhibit anti-tumor activities in a variety of human malignancies including NSCLC (non-small cell lung cancer). TAZ (transcriptional co-activator with PDZ-binding motif), one of the key activators in Hippo pathway, has been characterized as an oncoprotein. Therefore, inhibition of TAZ could be useful for the treatment of human cancers. In the current study, we aimed to explore whether rottlerin inhibits the expression of TAZ in NSCLC, leading to its anti-cancer activity. Multiple approaches were applied for determining the mechanism of rottlerin-mediated anti-tumor function, including cell growth assay, Flow cytometry, wound healing assay, invasion assay, Western blotting, and transfection. We found that rottlerin inhibited cell growth, triggered apoptosis, arrested cell cycle, and retarded cell invasion in NSCLC cells. Moreover, our results showed that overexpression of TAZ enhanced cell growth, stimulated apoptosis, and promoted cell migration and invasion. Consistently, inhibition of TAZ exhibited anti-tumor activity in NSCLC cells. Notably, we validated that rottlerin exerted its tumor suppressive function via inactivation of TAZ in NSCLC cells. Taken together, our study indicates that inhibition of TAZ by rottlerin could be a promising strategy for the prevention and therapy of NSCLC.

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Section: Introductionmentioning

confidence: 99%

Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer

et al. 2016

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“…These toxic components affect as enterotoxins and neurotoxins (Oelrichs et al, 1983). Alkaloids, flavonoids, limonoids, steroids and triterpenoids are also isolated from leaves and barks of tree (Ge et al, 2016;Pan et al, 2014). Other potentially toxic components comprise azadarin (alkaloid), meliotannic acid, benzoic acid, and resins such as azaridine, parisine, and margosinine (Plumlee, 2003).…”

Section: Toxic Componentsmentioning

confidence: 99%

Poisonous Plants for Cats and Dogs Kept in House 1: Dieffenbachia spp., Melia azedarach, Ricinus communis, Euphorbia pulcherrima, Narcissus spp.

Bilgili¹,

Hanedan²,

Uysal³

2020

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)

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Poisonous plants are responsible for many poisoning events. These plants are commonly grown in homes and gardens and are eaten by dogs and cats. In this context, it was dealt with poisonous effects of especially Dieffenbachia spp., chinaberry tree (Melia azedarach), castor bean (Ricinus communis), poinsettia (Euphorbia pulcherrima) and daffodil (Narcissus spp.) from plants leading to poisoning, grown commonly in parks, gardens, and homes, in our country. The plant species leading to poisoning for both dogs and cats were presented in table. In addition, comprehensive information was presented on their adverse effects in different organ and tissues occurring in the result that they are eaten by dogs and cats, their clinical signs, and their treatments. The concise knowledge was given on the required measures for preventing poisoning of animals kept in home with these plants in also our country, as in world countries.

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“…Natural products and their derivatives have been used as anticancer agents and present a potential source of new drugs to combat cancer 22 – 24 . To identify potential YAP/TAZ inhibitors, we previously performed a YAP/TAZ luciferase reporter activity-based screening of a library of natural products (Selleckchem, Houston, TX, USA), and found that apigenin decreased YAP/TAZ activity.…”

Section: Introductionmentioning

confidence: 99%

Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity

Zhu

et al. 2018

Cell Death Discovery

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Triple-negative breast cancer (TNBC) remains a clinical challenge because of the absence of effective therapeutic targets. In TNBC, overexpression of YAP and TAZ correlates with bioactivities of cancer stem cells (CSCs), high histological grade, resistance to chemotherapy, and metastasis. Thus, YAP/TAZ may serve as potential therapeutic targets in TNBC. To identify YAP/TAZ inhibitors, in previous experiments, we screened a library of natural compounds by using YAP/TAZ luciferase reporter assay and identified apigenin as a potential inhibitor. In this study, we demonstrated that apigenin significantly suppressed the proliferation and migration of TNBC cells. Furthermore, we demonstrated that apigenin inhibited stemness features of TNBC cells in both in vitro and in vivo assays. Our mechanism study demonstrated that apigenin decreased YAP/TAZ activity and the expression of target genes, such as CTGF and CYR61, in TNBC cells. We also showed that apigenin disrupted the YAP/TAZ-TEADs protein–protein interaction and decreased expression of TAZ sensitized TNBC cells to apigenin treatment. Collectively, our studies suggest that apigenin is a promising therapeutic agent for the treatment of TNBC patients with high YAP/TAZ activity.

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Two new tetracyclic triterpenoids from the barks of Melia azedarach

Abstract: Two new tetracyclic triterpenoids, together with 21 known compounds, were isolated from the barks of Melia azedarach. The structures of new compounds were elucidated by the means of HRESIMS, 1D NMR, 2D NMR, and X-ray crystallography analysis.

Cited by 8 publications

References 18 publications

Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer

Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer

Poisonous Plants for Cats and Dogs Kept in House 1: Dieffenbachia spp., Melia azedarach, Ricinus communis, Euphorbia pulcherrima, Narcissus spp.

Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity

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