Upconversion fluorescence metal-organic frameworks thermo-sensitive imprinted polymer for enrichment and sensing protein

Guo, Ting; Deng, Qiling; Fang, Guozhen; Gu, Dahai; Yang, Yukun; Wang, Shuo

doi:10.1016/j.bios.2015.12.040

Cited by 110 publications

(30 citation statements)

References 38 publications

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“…However, there are also some challenges for bio‐macromolecules, especially proteins, due to the structural complexity, conformational flexibility, large molecular size and poor solubility in water . Accordingly, more promising alternative techniques have been exploited to overcome these barriers from different viewpoints . Surface imprinting is one of the most widely used methods, which locates all affinity recognition sites on the polymer surfaces; thus the diffusion of large macromolecules into and out of the network is facilitated.…”

Section: Introductionmentioning

confidence: 99%

Preparation of pH and temperature dual‐sensitive molecularly imprinted polymers based on chitosan and N‐isopropylacrylamide for recognition of bovine serum albumin

Dong

Hou

et al. 2019

Polymer International

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pH and temperature dual‐sensitive protein imprinted microspheres with high absorption capacity have been successfully synthesized on the surface of SiO2 using chitosan grafted N‐isopropylacrylamide (CS‐g‐NIPAM) as the pH and temperature sensitive monomer, with acrylamide as comonomer, N,N′‐methylenebisacrylamide as the crosslinking agent and bovine serum albumin (BSA) as the template protein. The pH and temperature dual‐sensitivity was also investigated. The results showed that the adsorption capacity and imprinting factor improved slowly with increasing incubation pH from 4.6 to 7.0, and then decreased sharply in alkaline conditions due to the reduction of non‐specific binding from electrostatic and hydrogen bonding interactions. Fourier transform infrared spectroscopy, thermogravimetric analysis and transmission electron microscopy were used to characterize the polymers. The as‐prepared SiO2@BSA molecularly imprinted polymers were also found to have high adsorption capacity (119.88 mg g−1) within 2 h, an excellent imprinting factor (α = 2.25), specific selectivity and good reusability. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Preparation of pH and temperature dual‐sensitive molecularly imprinted polymers based on chitosan and N‐isopropylacrylamide for recognition of bovine serum albumin

Dong

Hou

et al. 2019

Polymer International

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“…Recently, molecular imprinting technology has rapidly developed as a preparative technique that has been successfully applied to biomimetic sensors, chromatographic separation, biomaterial simulations, medical diagnostics, drug deliveries, and enzyme mimicking catalysis [15][16][17][18][19][20][21]. Molecularly imprinted polymers (MIPs) are also known as artificial and tailor-made receptors with the ability of specially recognition target molecules, with the attractive features of high selectivity and sensitivity, low cost and reusability, high mechanical and chemical strength, easy preparation and good stability in a wide range of solvents and temperature [13,[22][23][24][25][26]. These polymers act as artificial antibodies with the ability to recognize and bind to the template or its analogs [27].…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, MIPs are prepared by bulk polymerization, dispersion polymerization, or suspension polymerization. However, there are certain drawbacks that exist such as long adsorption time, low binding capacity and selectivity, irregular shape and poor sites accessible due to the crushed polymers and incomplete template removal [31][32][33][34][35]. To overcome these limitations, surface imprinting has been developed in recent years [35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein‐95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies

Huang

Zhang

et al. 2017

J of Separation Science

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In the scope of stroke treatment, new neuronal nitric oxide synthase-postsynaptic density protein-95 uncouplers from herbal medicines were discovered and captured. To do so, highly selective magnetic molecularly imprinted polymers with a core-shell structure were prepared as artificial antibodies. According to the results of computational simulations, we designed and synthesized various polymers with varying amounts and types of template, functional monomer, cross-linker, and solvent. Characterization and performance tests revealed that the most appropriate artificial antibodies showed uniform spherical morphologies, large adsorption capacities, fast-binding kinetics, high selectivity, and quick separation. These artificial antibodies were then used as sorbents for dispersive magnetic solid-phase extraction coupled with high-performance liquid chromatography and mass spectrometry to capture and identify structural analogs to ZL006 from extracts of Scutellariae radix, Psoraleae fructus, and Trifolium pratense. Furthermore, according to the neuroprotective effect and coimmunoprecipitation test, Baicalein, Neobavaisoflavone, Corylifol A, and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. Therefore, this present study contributes valuable information for the discovery of neuronal nitric oxide synthase-postsynaptic density protein-95 uncouplers from herbal medicines.

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“…A fluorescence-based sensor was developed by Guo et al [46] for the detection of hemoglobin using bovine hemoglobin as the template molecule, N-isopropyl acrylamide as the temperature-sensitive functional monomer and N,N-methylene bisacrylamide as the cross-linker. Cu 3 (BTC) 2 was used as a representative of the MOF and upconversion nanoparticles were used as fluorescence materials.…”

Section: Sensors Based On Molecularly Imprinted Core-shell Nanoparticmentioning

confidence: 99%

“…The MOF@MIP optical sensor developed by Guo et al [46] was applied for the detection of hemoglobin. The recognition capability of the imprinted MOF@MIP material was evaluated through the change of the fluorescence signal of the hybrid material at various concentrations of hemoglobin ranging from 0 to 0.6 mg/mL, with a detection limit of 0.062 mg/mL.…”

Section: Sensors Based On Molecularly Imprinted Core-shell Nanoparticmentioning

confidence: 99%

Molecularly Imprinted Polymer/Metal Organic Framework Based Chemical Sensors

et al. 2016

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Abstract:The present review describes recent advances in the concept of molecular imprinting using metal organic frameworks (MOF) for development of chemical sensors. Two main strategies regarding the fabrication, performance and applications of recent sensors based on molecularly imprinted polymers associated with MOF are presented: molecularly imprinted MOF films and molecularly imprinted core-shell nanoparticles using MOF as core. The associated transduction modes are also discussed. A brief conclusion and future expectations are described herein.

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Upconversion fluorescence metal-organic frameworks thermo-sensitive imprinted polymer for enrichment and sensing protein

Cited by 110 publications

References 38 publications

Preparation of pH and temperature dual‐sensitive molecularly imprinted polymers based on chitosan and N‐isopropylacrylamide for recognition of bovine serum albumin

Preparation of pH and temperature dual‐sensitive molecularly imprinted polymers based on chitosan and N‐isopropylacrylamide for recognition of bovine serum albumin

Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein‐95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies

Molecularly Imprinted Polymer/Metal Organic Framework Based Chemical Sensors

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