Decrease in Candida bloodstream infections in veterans in Atlanta

Kabbani, Sarah; Jacob, Jesse T; Gaynes, Robert P.; Rimland, David

doi:10.1016/j.ajic.2015.11.003

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Cyclic lipopeptide antibiotics such as polymyxin B and daptomycin , are drugs marketed for the treatment of infections caused by Gram-positive and Gram-negative bacteria, respectively. Inspired by the structures, we have developed a series of lipo-cyclic α-AApeptides.…”

Section: Function Of Aapeptidesmentioning

confidence: 99%

Structure and Function of AApeptides

Bolarinwa

Nimmagadda

et al. 2017

Biochemistry

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The intrinsic drawbacks encountered in bioactive peptides in chemical biology and biomedical sciences have diverted research efforts to the development of sequence-specific peptidomimetics that are capable of mimicking the structure and function of peptides and proteins. Modifications in the backbone and/or the side chain of peptides have been explored to develop biomimetic molecular probes or drug leads for biologically important targets. To expand the family of oligomeric peptidomimetics to facilitate their further application, we recently developed a new class of peptidomimetics, AApeptides based on a chiral peptide nucleic acid backbone. AApeptides are resistant to proteolytic degradation and amenable to enormous chemical diversification. Moreover, they could mimic the primary structure of peptides and also fold into discrete secondary structure such as helices and turn-like structures. Furthermore, they have started to show promise in applications in material and biomedical sciences. Herein, we highlight the structural design and some function of AApeptides and present our perspective on their future development.

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Section: Function Of Aapeptidesmentioning

confidence: 99%

Structure and Function of AApeptides

Bolarinwa

Nimmagadda

et al. 2017

Biochemistry

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Epidemiologic characteristics of adult candidemic patients in a secondary hospital in Kuwait: A retrospective study

Alobaid

Khan

2019

Journal de Mycologie Médicale

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Improvement of fungal disease identification and management: combined health systems and public health approaches

Cole

Govender

Chakrabarti

et al. 2017

The Lancet Infectious Diseases

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More than 1·6 million people are estimated to die of fungal diseases each year, and about a billion people have cutaneous fungal infections. Fungal disease diagnosis requires a high level of clinical suspicion and specialised laboratory testing, in addition to culture, histopathology, and imaging expertise. Physicians with varied specialist training might see patients with fungal disease, yet it might remain unrecognised. Antifungal treatment is more complex than treatment for bacterial or most viral infections, and drug interactions are particularly problematic. Health systems linking diagnostic facilities with therapeutic expertise are typically fragmented, with major elements missing in thousands of secondary care and hospital settings globally. In this paper, the last in a Series of eight papers, we describe these limitations and share responses involving a combined health systems and public health framework illustrated through country examples from Mozambique, Kenya, India, and South Africa. We suggest a mainstreaming approach including greater integration of fungal diseases into existing HIV infection, tuberculosis infection, diabetes, chronic respiratory disease, and blindness health programmes; provision of enhanced laboratory capacity to detect fungal diseases with associated surveillance systems; procurement and distribution of low-cost, high-quality antifungal medicines; and concomitant integration of fungal disease into training of the health workforce.

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Decrease in Candida bloodstream infections in veterans in Atlanta

Cited by 4 publications

References 8 publications

Structure and Function of AApeptides

Structure and Function of AApeptides

Epidemiologic characteristics of adult candidemic patients in a secondary hospital in Kuwait: A retrospective study

Improvement of fungal disease identification and management: combined health systems and public health approaches

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