Neonatal Infection and Later Neurodevelopmental Risk in the Very Preterm Infant

Rand, Katherine; Austin, Nicola; Inder, Terrie E.; Bora, Samudragupta; Woodward, Lianne J.

doi:10.1016/j.jpeds.2015.11.017

Cited by 85 publications

(74 citation statements)

References 42 publications

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“…In addition, neonatal infections, which are associated with inflammatory responses, and systemic inflammation during the first postnatal month increased the risk of ADHD [51,52]. To sum up, the evaluation of serum levels of inflammatory markers in ADHD patients has provided mixed results, likely due to small sample sizes and a high heterogeneity between biomarkers.…”

Section: Biochemical Markersmentioning

confidence: 99%

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

Leffa

Torres

Rohde

2018

Neuroimmunomodulation

126

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Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition that impairs quality of life in social, academic, and occupational contexts for both children and adults. Although a strong neurobiological basis has been demonstrated, the pathophysiology of ADHD is still poorly understood. Among the proposed mechanisms are glial activation, neuronal damage and degeneration, increased oxidative stress, reduced neurotrophic support, altered neurotransmitter metabolism, and blood-brain barrier disruption. In this way, a potential role of inflammation has been increasingly researched. However, evidence for the involvement of inflammation in ADHD is still scarce and comes mainly from (1) observational studies showing a strong comorbidity of ADHD with inflammatory and autoimmune disorders; (2) studies evaluating serum inflammatory markers; and (3) genetic studies. A co-occurrence of ADHD with inflammatory disorders has been demonstrated in a large number of subjects, suggesting a range of underlying mechanisms such as an altered immune response, common genetics, and environmental links. The evaluation of serum inflammatory markers has provided mixed results, likely due to the small sample sizes and high heterogeneity between biomarkers. However, there is evidence that increased inflammation during the early development may be a risk factor for ADHD symptoms. Although genetic studies have demonstrated a potential role for inflammation in this disorder, there is no clear evidence. To sum up, inflammation may be an important mechanism in ADHD pathophysiology, but more studies are still needed for a more precise conclusion.

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Section: Biochemical Markersmentioning

confidence: 99%

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

Leffa

Torres

Rohde

2018

Neuroimmunomodulation

126

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“…Asimismo, los recién nacidos que recibieron reanimación durante su atención inmediata y presentaron sepsis tardía tuvieron mayor riesgo de presentar algún tipo de alteración del desarrollo psicomotor (p<0,01), similar a lo reportado por Rand, Inder y otros (9) .…”

Section: Discussionunclassified

“…Otros factores que contribuyen a las alteraciones en este grupo de recién nacidos incluyen la edad gestacional, las complicaciones respiratorias, la displasia broncopulmonar, las infecciones maternas o sepsis neonatal, entre otros. Si bien se ha logrado mejorar la sobrevida de los prematuros de muy bajo peso al nacer, la tarea pendiente es que dicha sobrevida suceda con menos morbilidades (9,10) .…”

Section: Introductionunclassified

Teamwork en medicina: una necesidad

et al. 2017

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Secuelas del neurodesarrollo de recién nacidos prematuros de extremadamente bajo peso y de muy bajo peso a los dos años de edad, egresados de la Unidad de Cuidados Intensivos Neonatales del Hospital Nacional Edgardo Rebagliati Martins 2009-2014Carmen Fernández Sierra 1 , Juan Matzumura Kasano 2 , Hugo Gutiérrez Crespo 3 , Luisa Zamudio Eslava 4 , Giannina Melgarejo García 5 RESUMEN Objetivo: Describir las secuelas del neurodesarrollo de los recién nacidos prematuros de extremadamente bajo peso y de muy bajo peso a los dos años de edad, egresados de la Unidad de Cuidados Intensivos Neonatales del Hospital Nacional Edgardo Rebagliati Martins. Materiales y métodos: Estudio descriptivo, retrospectivo, transversal en una población de 190 prematuros de extremadamente bajo peso y de muy bajo peso que nacieron durante enero 2009 a junio del 2014, egresados de la Unidad de Cuidados Intensivos Neonatales, que asistieron al programa de seguimiento. Se evaluaron el desarrollo psicomotor, hipoacusia neurosensorial, retinopatía de la prematuridad, presencia de parálisis cerebral y síndrome convulsivo. Resultados: El promedio de peso al nacimiento fue 1.180,53 ± 212,40 gramos con edad gestacional de 29,86 ± 2,33 semanas, y el 51,58% fue de sexo masculino. El 42,63% de los recién nacidos prematuros de muy bajo peso presentó retraso del desarrollo psicomotor; el 25,26%, retinopatía; el 13,68%, hipoacusia neurosensorial; el 3,68%, parálisis cerebral; y el 3,68%, síndrome convulsivo. El 52,27% de los recién nacidos prematuros de extremadamente bajo peso presentó retraso en el desarrollo psicomotor; el 50%, retinopatía; el 15,91%, hipoacusia neurosensorial; y el 2,27%, síndrome convulsivo. Conclusiones: El retraso del desarrollo psicomotor y la retinopatía fueron las complicaciones más importantes que presentaron los recién nacidos prematuros de extremadamente bajo peso y los recién nacidos prematuros de muy bajo a los dos años de edad.Palabras clave: Neurodesarrollo; prematuro; recién nacido. Neurodevelopmental sequelae in premature newborns with extremely low weight and with very low weight at two years of age who left the Neonatal Intensive Care Unit of the Hospital Nacional Edgardo Rebagliati Martins 2009-2014ABSTRACT Objective: The purpose of this study is to describe the neurodevelopmental sequelae in premature newborns with extremely low weight and with very low weight at two years of age who left the Neonatal Intensive Care Unit of the Hospital Nacional Edgardo Rebagliati Martins. Materials and methods: A descriptive, retrospective, cross-sectional study in a population of 190 premature newborns with extremely low weight and with very low weight born from January 2009 to June 2014 who left the Neonatal Intensive Care Unit and took part in the follow-up program. The psychomotor development, sensorineural hearing loss, retinopathy of prematurity, presence of cerebral palsy and convulsive syndrome were assessed. Results: The average weight at birth was 1,180.53 ± 212.40 grams with a gestational age of 29.86 ± 2.33 weeks, and 5...

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“…56 100 101 A detailed exploration of the relative importance of different strategies to reduce their incidence is complex and beyond the scope of this review, since there are no consensus recommendations and trials are ongoing; however, some key interventions are briefly highlighted.…”

Section: Preventing Causative Morbiditiesmentioning

confidence: 99%

Protecting the premature brain: current evidence-based strategies for minimising perinatal brain injury in preterm infants

Lea

Smith-Collins

Luyt

2016

Arch Dis Child Fetal Neonatal Ed

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. INTRODUCTIONSurvival rates for preterm babies are increasing, 1 however severe neurological impairment remains a significant consequence of preterm birth.2 3 Research continues into potential treatments for reducing both the risk of initial brain injury and subsequent neurodevelopmental problems; 4 however, in the interim, these can be reduced by optimising currently approved and recommended practices.

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Neonatal Infection and Later Neurodevelopmental Risk in the Very Preterm Infant

Cited by 85 publications

References 42 publications

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

Teamwork en medicina: una necesidad

Protecting the premature brain: current evidence-based strategies for minimising perinatal brain injury in preterm infants

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