Autoimmune Neutropenia as a Cause of Periodontal Disease in Preschool Children

Abstract

In autoimmune neutropenia, autoantibodies attack neutrophils resulting in their destruction or alteration of their function. Since neutrophils have important immunologic functions, aberrations in their homeostasis lead to increased susceptibility to diseases, such as periodontitis. Periodontitis as a manifestation of neutropenia can affect adults and children. In this paper, we describe the treatment of periodontal disease in a 2-year-old female with autoimmune neutropenia. The importance of an interdisciplinary approach, frequent recalls, and meticulous mechanical therapy in stabilizing her periodontal condition, despite ongoing systemic infections is emphasized.

Some Important Facts about the Periodontal Disease

“…Deficiency in neutrophil function is associated with periodontal disease [29]. These are the chediak-higashi syndrome [30], cyclic neutropenia [31], lazy leukocyte syndrome, agranulocytosis, and leukocyte adhesion deficiency [32], Down's syndrome [33] and Papillon lefevre syndrome [34].…”