Epidemiology of<i>Haemophilus ducreyi</i>Infections

González-Beiras, Camila; Marks, Michael; Chen, Cheng Y.; Roberts, Sally; Mitjà, Oriol

doi:10.3201/eid2201.150425

Cited by 94 publications

(80 citation statements)

References 32 publications

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“…However, recent studies show that H . ducreyi is an important cause of nonsexually transmitted cutaneous ulcers in children in tropics in the South Pacific, South East Asia and Africa [1, 8–12]. Previous whole-genome sequencing of 6 CU strains from Samoa, Vanuatu and Papua New Guinea showed that these CU strains diverged from class I GU strains [7, 13].…”

Section: Discussionmentioning

confidence: 99%

“…ducreyi -associated CU—recently has been reported almost exclusively from countries that report no diagnostic data on chancroid [1, 25]. With the exception of the Central African Republic and Ghana, which report a 0.7% prevalence of chancroid in patients with GU [26], chancroid recently has been reported only in countries in which yaws is not thought to be endemic [1, 25]. This could mean that different routes of inoculation—sexual transmission for chancroid and nonsexual transmission for CU—have served to isolate GU and CU H .…”

Section: Discussionmentioning

confidence: 99%

“…Due to syndromic management of genital ulcers and lack of surveillance, the current global prevalence of chancroid is undefined but has declined over the last decade in many former endemic areas [1]. Phylogenetically, GU strains belong to 2 distinct groups called class I and class II, which differ in their expression of several surface proteins and lipooligosaccharide and in their susceptibility to vancomycin and diverged from each other approximately 1.95 million years ago [2–7].…”

Section: Introductionmentioning

confidence: 99%

“…ducreyi has emerged as an important cause of nonsexually transmitted cutaneous ulcers (CU) in children [1, 8–12]. In studies conducted in yaws-endemic villages on Vanuatu and Lihir Island of Papua New Guinea, H .…”

Section: Introductionmentioning

confidence: 99%

“…In Ghana and the Solomon Islands, H . ducreyi DNA was detected in 9% to 32% of CU, and no other pathogen DNA was detected [1, 9, 12]. The reasons for the variation in the sensitivities of the PCR-based tests in these studies are unclear; but the data suggest that a substantial proportion of cases of CU may be caused by organism(s) that are yet to be identified.…”

Section: Introductionmentioning

confidence: 99%

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Haemophilus ducreyi Cutaneous Ulcer Strains Diverged from Both Class I and Class II Genital Ulcer Strains: Implications for Epidemiological Studies

Gangaiah

Spinola

2016

PLoS Negl Trop Dis

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BackgroundHaemophilus ducreyi has emerged as a major cause of cutaneous ulcers (CU) in yaws-endemic regions of the tropics in the South Pacific, South East Asia and Africa. H. ducreyi was once thought only to cause the genital ulcer (GU) disease chancroid; GU strains belong to 2 distinct classes, class I and class II. Using whole-genome sequencing of 4 CU strains from Samoa, 1 from Vanuatu and 1 from Papua New Guinea, we showed that CU strains diverged from the class I strain 35000HP and that one CU strain expressed β-lactamase. Recently, the Center for Disease Control and Prevention released the genomes of 11 additional CU strains from Vanuatu and Ghana; however, the evolutionary relationship of these CU strains to previously-characterized CU and GU strains is unknown.Methodology/Principal FindingsWe performed phylogenetic analysis of 17 CU and 10 GU strains. Class I and class II GU strains formed two distinct clades. The class I strains formed two subclades, one containing 35000HP and HD183 and the other containing the remainder of the class I strains. Twelve of the CU strains formed a subclone under the class I 35000HP subclade, while 2 CU strains formed a subclone under the other class I subclade. Unexpectedly, 3 of the CU strains formed a subclone under the class II clade. Phylogenetic analysis of dsrA-hgbA-ncaA sequences yielded a tree similar to that of whole-genome phylogenetic tree.Conclusions/SignificanceCU strains diverged from multiple lineages within both class I and class II GU strains. Multilocus sequence typing of dsrA-hgbA-ncaA could be reliably used for epidemiological investigation of CU and GU strains. As class II strains grow relatively poorly and are relatively more susceptible to vancomycin than class I strains, these findings have implications for methods to recover CU strains. Comparison of contemporary CU and GU isolates would help clarify the relationship between these entities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Haemophilus ducreyi Cutaneous Ulcer Strains Diverged from Both Class I and Class II Genital Ulcer Strains: Implications for Epidemiological Studies

Gangaiah

Spinola

2016

PLoS Negl Trop Dis

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Macrolides for treatment of Haemophilus ducreyi infection in sexually-active adults

Huerfano

Grillo‐Ardila

Romero

et al. 2017

Cochrane Database of Systematic Reviews

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Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults

Romero

Huerfano

Grillo‐Ardila

2017

Cochrane Database of Systematic Reviews

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At present, the quality of the evidence on the effectiveness and safety of macrolides for treatment of H ducreyi infection in sexually active adults is low, implying that we are uncertain about the estimated treatment effect. There is no statistically significant difference between the available therapeutic alternatives for the treatment of sexually active adults with genital ulcers compatible with chancroid. Low quality evidence suggests that azithromycin could be considered as the first therapeutic alternative, based on their mono-dose oral administration, with a similar safety and effectiveness profile, when it is compared with long-term erythromycin use.Due to sparse available evidence about the safety and effectiveness of macrolides to treat H ducreyi infection in people with HIV, these results should be taken with caution.

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Epidemiology ofHaemophilus ducreyiInfections

Abstract: Infections are at their lowest level worldwide, but nongenital cutaneous infections have increased.

Cited by 94 publications

References 32 publications

Haemophilus ducreyi Cutaneous Ulcer Strains Diverged from Both Class I and Class II Genital Ulcer Strains: Implications for Epidemiological Studies

Haemophilus ducreyi Cutaneous Ulcer Strains Diverged from Both Class I and Class II Genital Ulcer Strains: Implications for Epidemiological Studies

Macrolides for treatment of Haemophilus ducreyi infection in sexually-active adults

Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults

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