Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic β-cell through JNK signaling

Lee, Hyunjung; Im, Sung Won; Jung, Chang Hwa; Jang, Young Jin; Ha, Tae Youl; Ahn, Jiyun

doi:10.1016/j.bbrc.2015.12.036

Cited by 32 publications

(19 citation statements)

References 31 publications

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“…In this respect, we confirm our recent findings (63) that olive polyphenols, administered in a functional food and at a dose compatible with the EFSA-suggested dose of olive oil, do not modify the circulating glucose levels, while they ameliorate insulin sensitivity. These results were further corroborated by the reported direct protective effect of polyphenols in the pancreas (64) and the amelioration of insulin secretion through an anti-inflammatory action of oleic acid (65).…”

Section: Discussionsupporting

confidence: 66%

Network Meta-Analysis of Metabolic Effects of Olive-Oil in Humans Shows the Importance of Olive Oil Consumption With Moderate Polyphenol Levels as Part of the Mediterranean Diet

Tsartsou

Proutsos²,

Castanas

et al. 2019

Front. Nutr.

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The beneficial role of olive oil consumption is nowadays widely recognized. However, it is not clear whether its health effects are due to the presence of monounsaturated lipids and/or to the antioxidant fraction of microconstituents present in olive oil. The aim of the present study was to analyze the exact role of olive oil in the modification of metabolic factors (glucose and circulating lipids) and explore the role of its antioxidant polyphenols. In the present work, we have performed a network meta-analysis of 30 human intervention studies, considering direct and indirect interactions and impact of each constituent. Interestingly, we show that the impact of olive oil on glucose, triglycerides, and LDL-cholesterol is mediated through an adherence to the Mediterranean diet, with the only notable effect of olive oil polyphenols being the increase of HDL-cholesterol, and the amelioration of the antioxidant and inflammatory status of the subjects. Additionally, we report for the first time that lower antioxidant polyphenol levels may be sufficient for the beneficial effects of olive oil, while we show that the lipid fraction of olive oil may be responsible for some of its beneficial actions. In all parameters examined the beneficial effect of olive oil was more pronounced in subjects with an established metabolic syndrome or other chronic conditions/diseases. In conclusion, all these findings provide new knowledge that could lead to re-establishment of the role of olive oil in human nutrition.

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Section: Discussionsupporting

confidence: 66%

Network Meta-Analysis of Metabolic Effects of Olive-Oil in Humans Shows the Importance of Olive Oil Consumption With Moderate Polyphenol Levels as Part of the Mediterranean Diet

Tsartsou

Proutsos²,

Castanas

et al. 2019

Front. Nutr.

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“…More recently, Lee et al. showed that tyrosol protected against β‐cell dysfunction and inhibited ER stress‐induced apoptosis in mouse insulinoma cells NT‐1 through JNK signaling. Moreover, our recent study demonstrated the beneficial effects of hydroxytyrosol in NAFLD, reducing IR, inflammation, and oxidative stress in rats .…”

Section: Introductionmentioning

confidence: 99%

Polyphenol‐rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high‐fat diet fed rats

Lama

Pirozzi

Mollica

et al. 2016

Molecular Nutrition Food Res

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“…Recently, tyrosol was able to increase the longevity of C. elegans [10] and could ameliorate hyperglycemia in diabetic rats [11]. Previously, our data showed that tyrosol prevents endoplasmic reticulum (ER) stress-induced apoptosis in pancreatic β-cells through JNK signaling, suggesting that tyrosol could be a potential therapeutic candidate for the amelioration of type 2 diabetes [12].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Tyrosol Metabolites in Rats

Lee

Kim

et al. 2016

Molecules

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Abstract:Tyrosol is considered a potential antioxidant; however, little is known regarding the pharmacokinetics of its metabolites. To study the pharmacokinetics of tyrosol-derived metabolites after oral administration of a single dose of tyrosol, we attempted to identify tyrosol metabolites in rat plasma by using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Two tyrosol metabolites (M1 and M2) were detected in the plasma. M1 was identified as tyrosol-4-sulfate (T4S) with an [M´H]´ion at m/z 217. While M2 showed an [M´H]´ion at m/z 151.0, its metabolite was not identified. Pharmacokinetic analysis of T4S and M2 showed rapid uptake after oral administration of tyrosol within 1 h. The metabolites were rapidly distributed in most organs and tissues and eliminated within 4 h. The greatest T4S deposition by tissue weight was observed in the liver, followed by the kidney and spleen, while M2 was most concentrated in the kidney followed by the liver and spleen. These findings indicate that T4S and M2 were distributed mainly in tissues with an abundant blood supply and were rapidly excreted in urine.

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Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic β-cell through JNK signaling

Cited by 32 publications

References 31 publications

Network Meta-Analysis of Metabolic Effects of Olive-Oil in Humans Shows the Importance of Olive Oil Consumption With Moderate Polyphenol Levels as Part of the Mediterranean Diet

Network Meta-Analysis of Metabolic Effects of Olive-Oil in Humans Shows the Importance of Olive Oil Consumption With Moderate Polyphenol Levels as Part of the Mediterranean Diet

Polyphenol‐rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high‐fat diet fed rats

Pharmacokinetics of Tyrosol Metabolites in Rats

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