“…These pathways contain differentially expressed genes encoding multiple proteins that are known to be associated axon and synapse dysfunction or degeneration in other neurodegenerations. These include multiple members of the ephrin family of receptors ( Epha2, Epha4, Epha5, Epha6, Ephb2, Ephb3, Ephb4 Ephb6 ; Chen et al, 2012), metabotropic glutamate receptors ( Grm3, Grm5, Grm6, Grm7 ; Ribeiro et al, 2017), Ryr3 (Balschun et al, 1999; Del Prete et al, 2014), and semaphorins ( Sema3a, Sema3b, Sema3d, Sema4a, Sema5a, Sema6a, Sema6c, Sema7a ; Shirvan et al, 2002; Good et al, 2004; Pasterkamp and Giger, 2009; Smith et al, 2015; Gutiérrez-Franco et al, 2016). There are no significantly enriched pathways in D2 Group 1 or D2 + NAM samples compared to controls.…”