Association of Interleukin 7 Receptor (rs1494555 and rs6897932) Gene Polymorphisms with Asthma in a North Indian Population

Sinha, Shweta; Singh, Jagtar; Jindal, Surinder K.

doi:10.2500/ar.2015.6.0137

Cited by 8 publications

(9 citation statements)

References 31 publications

(44 reference statements)

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“… 118 With regard to asthma, an association of the rs6897932 C allele and increased risk of disease was demonstrated in an Indian cohort. 114 Similarly, in a cohort with Type 1 Diabetes, Todd et al have observed an association between rs6897932 SNP and this autoimmune disorder. 65 Subsequently, Santiago and colleagues have confirmed this association.…”

Section: Scd127 In Diseasementioning

confidence: 91%

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Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent

Barros¹,

Berthoud²,

Aloufi³

et al. 2021

ITT

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Soluble cytokine receptors can influence immune responses by modulating the biological functions of their respective ligands. These effects can be either agonistic or antagonistic and a number of soluble cytokine receptors have been shown to play critical roles in both maintenance of health and disease pathogenesis. Soluble IL-7Ra (sCD127) is one such example. With its impact on the IL-7/CD127 pathway, which is fundamental for the development and homeostasis of T cells, the role of sCD127 in health and disease has been extensively studied in recent years. Within this review, the role of sCD127 in maintaining host immune function is presented. Next, by addressing genetic factors affecting sCD127 expression and the associated levels of sCD127 production, the roles of sCD127 in autoimmune disease, infections and cancer are described. Finally, advances in the field of soluble cytokine therapy and the potential for sCD127 as a biomarker and therapeutic agent are discussed.

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Section: Scd127 In Diseasementioning

confidence: 91%

“…Beyond its association with CNS autoimmunity, numerous studies have suggested that the rs6897932 SNP might be involved with other autoimmune disorders and immune-mediated conditions. These include asthma, 114 type 1 diabetes, 115 sarcoidosis, 116 rheumatoid arthritis, 117 and systemic lupus erythematosus (SLE). 118 …”

Section: Scd127 In Diseasementioning

confidence: 99%

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent

Barros¹,

Berthoud²,

Aloufi³

et al. 2021

ITT

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“…Although the association of rs6897932 polymorphism with MS has not been investigated, its association with other autoimmune disorders, such as systemic lupus erythematosus, 24 and asthma has been established. 25 It is believed that rs6897932 polymorphism regulates monocyte surface IL7R induction by lipopolysaccharides and tumor necrosis factor stimulation. 26…”

Section: Resultsmentioning

confidence: 99%

Association of rs12487066, rs12044852, rs10735781, rs3135388, rs6897932, rs1321172, rs10492972, and rs9657904 Polymorphisms with Multiple Sclerosis in Iranian Population

et al. 2020

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Objectives Multiple sclerosis (MS) is a chronic disease of the central nervous system. The pathogenesis of MS is best described by a multifactorial model incorporating interactions between genetic and environmental factors with the role of genetic factors increasingly taken into account. The main goal of this study was to investigate the associations of rs12487066, rs12044852, rs10735781, rs3135388, rs6897932, rs1321172, rs10492972, and rs9657904 polymorphisms with MS in the Iranian population. Methods A total of 83 patients with MS (82.0% female and 18.0% male; mean age = 35.2±8.6 years) and 100 physically and mentally healthy subjects (81.0% female and 19.0% male; mean age = 40.4±6.4 years) were selected using convenient sampling. A 5 mL blood sample was taken from each case and control patient. We used the tetra-primer ARMS-PCR method to genotype the desired polymorphisms. The associations between polymorphisms and the disease were studied based on codominant, dominant, recessive, and overdominant models. Results The rs10735781 polymorphism was codominantly ( p = 0.029), overdominantly ( p = 0.008), and dominantly ( p = 0.009) associated with the disease. The rs6897932 was also found to be codominantly ( p = 0.012), dominantly ( p = 0.019), and recessively ( p = 0.011) associated with the disease. Conclusions We found an association between the rs10735781 and rs6897932 polymorphisms on the EVI5 and IL7RA genes, respectively, with increased MS in the Iranian population. Therefore, single nucleotide polymorphisms in the EVI5 and IL7RA genes can be considered a prognostic marker of MS.

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“…Genetic variation polymorphisms of IL-7R has been reported to affect the occurrence of many diseases. Sinha et al [24] found that polymorphisms of IL-7R (rs1494555 and rs6897932) were associated with asthma in the northern Indian population. IL-7R -rs6897932 (C/T) was related to the susceptibility of systemic lupus erythematosu [25].…”

Section: Discussionmentioning

confidence: 99%

Correlation between IL‐7R gene variants and breast cancer susceptibility in Chinese Han women

Li¹,

Yue²,

Zuo³

et al. 2020

Preprint

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Introduction IL-7R is involved in the occurrence and development of breast cancer by binding to its ligand IL-7. This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibility in Chinese Han women.Methods Five polymorphisms (rs969129, rs10213865, rs10053847, rs118137916, and rs6451231) of IL-7R genewere genotyped in 553 patients and 550 healthy healthy individuals from the in Chinese Han women using the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated used to evaluate the relationship.Results IL-7R rs10213865, rs969129 and rs6451231 was correlated with an increased the risk of breast cancer in multiple genetic models. Age stratified analysis revealed that rs6451231 was correlated with an increased breast cancer risk at age > 52 years. Additionally, rs10213865 was correlated with tumor site and ER expression, rs969129 was related to tumor size and Ki67 expresses status, and rs6451231was related to tumor size. Haplotype CGAG (rs969129, rs10213865, rs10053847 and rs118137916) were observed to a decrease breast cancer risk.Conclusions IL-7R polymorphism were significantly correlated with an increased breast cancer susceptibility in Chinese Han women.

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Association of Interleukin 7 Receptor (rs1494555 and rs6897932) Gene Polymorphisms with Asthma in a North Indian Population

Cited by 8 publications

References 31 publications

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent

Association of rs12487066, rs12044852, rs10735781, rs3135388, rs6897932, rs1321172, rs10492972, and rs9657904 Polymorphisms with Multiple Sclerosis in Iranian Population

Correlation between IL‐7R gene variants and breast cancer susceptibility in Chinese Han women

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