Chlorella vulgaris reduces the impact of stress on hypothalamic–pituitary–adrenal axis and brain c-fos expression

Queiroz, Julia Souza; Blasco, Ignacio Marin; Gagliano, Humberto; Daviu, Núria; Gómez-Román, Almudena; Belda, Xavier; Carrasco, Javier; Rocha, Michelle C.; Neto, José Pereira de Queiroz; Armario, Antonio

doi:10.1016/j.psyneuen.2015.12.002

Cited by 12 publications

(7 citation statements)

References 37 publications

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“…Therefore, as solution and alternative route of utilization, this present study agreed with exploitation of functional health and physiological properties of the microalgal for promotion of animal production and health (Azizzat et al 2010). Beyond amelioration of stress-associated growth and performance, supplementation of Chlorella vulgaris could contribute to improved physiological functions of the brain and hypothalamus axis, thereby leading to improved reproduction (Queiroz et al 2016); supplementation of Chlorella vulgaris was also reported to protect against chemical cadmium toxicity via its detoxification in rat model (Kim et al 2009;Elsheikh et al 2018); it was also reported for testicular protection against lead toxicity in Nile tilapia according to reports of Zahran and Risha (2014).…”

Section: Discussionsupporting

confidence: 78%

Dietary supplementation effects of Chlorella vulgaris on performances, oxidative stress status and antioxidant enzymes activities of prepubertal New Zealand White rabbits

et al. 2019

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Background: Chlorella vulgaris (CV) is a natural source of functional antioxidants capable of protecting against oxidative stress; its dietary supplementation in animals can serve as a way of improving animals' performance and productive output; on this background, the microalgae was supplemented to growing New Zealand white rabbits and its effects on performances and oxidative stress status were evaluated. Method: Thirty-five (35) 6-week-old New Zealand White rabbits (935.48 ± 5.92 g) were divided into five groups (n = 7 per group) in a completely randomized design experiment; rabbits in control groups were fed only commercial rabbits feed, while rabbits in treatment groups were supplemented with 200, 300, 400, and 500 mg Chlorella vulgaris biomass per kilogram of the body weight along with commercial rabbits feed daily. Feed intake and body weight changes were recorded daily and weekly; at the end of the study, blood was collected and subjected to chemical assays for evaluation of serum oxidative stress markers and antioxidant activities. Results: Dietary supplementation of the microalgae significantly increased the rabbits' growth weights (p < 0.01) without significant increase or reduction in feed intakes (p < 0.56), but significantly enhanced feed to gain ratio. The microalgae supplementation significantly protected the rabbits against oxidative stress damages through the reduction of malondialdehyde concentrations (p < 0.001) and increased total antioxidant capacity (p < 0.003). It also led to higher superoxide dismutase activity (p < 0.001), increased catalase activity (p < 0.003), and higher concentration of reduced glutathione (p < 0.001). Conclusion: It was concluded from outcomes of both performance and biochemical analysis of the rabbits that daily supplementation of Chlorella vulgaris between 200 and 500 mg per kilogram of the body weight in prepubertal rabbits significantly improved performances in forms of higher weight gains and enhanced feed utilization; it also protected against oxidative stress damages hence it was recommended as dietary antioxidant supplement for growing prepubertal rabbits.

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Section: Discussionsupporting

confidence: 78%

Dietary supplementation effects of Chlorella vulgaris on performances, oxidative stress status and antioxidant enzymes activities of prepubertal New Zealand White rabbits

et al. 2019

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“…Immediate early genes such as c-fos are extensively used to map brain areas involved in stress responses [174]. Using c-fos expression, Oueiroz et al [175] evaluated the effect of acute pretreatment with Chlorella (C. vulgaris) on the peripheral and central responses to forced swimming stress in rats. Chlorella supplementation produced a significant reduction in stress-related hypothalamic-pituitary-adrenal axis activation due to decreased corticotrophin releasing factor gene expression in the hypothalamic paraventricular nucleus and a lower adrenocorticotropic hormone response.…”

Section: Other Effectsmentioning

confidence: 99%

Potential of Chlorella as a Dietary Supplement to Promote Human Health

Bito

Okumura²,

Fujishima³

2020

Nutrients

134

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Chlorella is a green unicellular alga that is commercially produced and distributed worldwide as a dietary supplement. Chlorella products contain numerous nutrients and vitamins, including D and B12, that are absent in plant-derived food sources. Chlorella contains larger amounts of folate and iron than other plant-derived foods. Chlorella supplementation to mammals, including humans, has been reported to exhibit various pharmacological activities, including immunomodulatory, antioxidant, antidiabetic, antihypertensive, and antihyperlipidemic activities. Meta-analysis on the effects of Chlorella supplementation on cardiovascular risk factors have suggested that it improves total cholesterol levels, low-density lipoprotein cholesterol levels, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels but not triglycerides and high-density lipoprotein cholesterol levels. These beneficial effects of Chlorella might be due to synergism between multiple nutrient and antioxidant compounds. However, information regarding the bioactive compounds in Chlorella is limited.

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“…Sprague-Dawley rats supplemented (by gavage) with C. vulgaris (50 or 200mg/Kg/b.w. ), for instance, showed diminished peripheral and central responses to forced swimming stress tests, as seen through smaller corticotropin-releasing factor and c-fos expression levels [34]. Bae et al (2013) investigated the effects of C. vulgaris aqueous extracts on in vitro immuno-allergic responses using rat peritoneal mast cells, and in vivo through evaluation of plasma markers.…”

Section: Dietary Use and Effects Of Chlorella On Healthmentioning

confidence: 99%

Chlorella vulgaris as a Source of Essential Fatty Acids and Micronutrients: A Brief Commentary

Freitas¹

2017

TOPSJ

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Polyunsaturated fatty acids (PUFAs) comprise about 35-40% of the total lipid content from green algae Chlorella, reaching up to 24% linoleic acid and 27% α-linolenic acid in C. vulgaris. Also, microalgae nutrient composition may be modulated by changes in the culture medium, increasing fatty acid and microelement concentrations in the algae biomass. PUFAs, such as α-linolenic (n-3) and linoleic (n-6) acids, as well as its derivatives, are considered essential for dietary consumption, and their ability to regulate body chemistry has been recently explored in depth. A balanced fatty acid consumption is shown to counteract the negative effects of western diets, such as chronic inflammation and glucose intolerance. In this brief commentary, technological and practical uses of C. vulgaris are explored as means to improve dietary quality and, ultimately, human health.

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Chlorella vulgaris reduces the impact of stress on hypothalamic–pituitary–adrenal axis and brain c-fos expression

Cited by 12 publications

References 37 publications

Dietary supplementation effects of Chlorella vulgaris on performances, oxidative stress status and antioxidant enzymes activities of prepubertal New Zealand White rabbits

Dietary supplementation effects of Chlorella vulgaris on performances, oxidative stress status and antioxidant enzymes activities of prepubertal New Zealand White rabbits

Potential of Chlorella as a Dietary Supplement to Promote Human Health

Chlorella vulgaris as a Source of Essential Fatty Acids and Micronutrients: A Brief Commentary

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