Évaluation de l’efficacité de la sélection médicale des donneurs de sang dans la prévention des agents infectieux

Seck, Moussa; Dièye, Baba; Guèye, Y.A.N.; Faye, Blaise Felix; Senghor, Alioune Badara; Touré, Sokhna Aïssatou; Dieng, Nata; Sall, Abibatou; Touré, Alpha Oumar; Diéye, Tandakha Ndiaye; Diop, S.N.

doi:10.1016/j.tracli.2015.11.001

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…Donor safety ( 1 , 2 ) is targeted by reducing the risk of complications associated with blood donation (rare but not absent) ( 3 ) and, in order to improve recipient safety, blood donor selection attempts to reduce the risk of transfusion-transmitted infections (TTI). A recent study conducted in Senegal confirmed what is globally accepted based on epidemiological data, i.e., the efficacy of blood donor selection in reducing the prevalence of HIV seropositive donors ( 4 ).…”

Section: Introductionsupporting

confidence: 55%

An Original Approach to Evaluating the Quality of Blood Donor Selection: Checking Donor Questionnaires and Analyzing Donor Deferral Rate

Gillet¹,

Neijens²

2018

Front. Med.

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Blood donor selection is a cornerstone for blood transfusion safety, designed to safeguard the health of both donors and recipients. In the Service du Sang, Belgian Red Cross, French and German-speaking part of Belgium (SFS), health professionals (HPs) are allowed to interview donors on their own after formal qualification. This qualification is afterward evaluated by means of two complementary quality indicators: monitoring of donor health questionnaires (DHQs) and analysis of donor deferral rate. The study aims to evaluate the degree to which both quality indicators may be useful and appropriate tools to evaluate the quality of blood donor selection. An analysis performed on 2016 data showed that noncompliance detected by means of DHQ monitoring seems to be more frequent in HPs who conduct a low number of interviews compared to all HPs as a group (5.67 vs. 3.23%; p < 0.001). Deferral rates are also higher in HPs with a lower activity compared to HPs who interview more donors (14.80 vs. 13.00%, p < 0.001). Furthermore, statistically differences are observed between the type of blood donation venue in terms of the global deferral rate (for instance fixed site vs. schools: 11.9 vs. 19.5%; p < 0.001), and specific reasons for deferral (such as sexual risk behavior and travel in at-risk areas, the differences being highly significant between each category of blood donation venue; p < 0.001). Providing the HPs with feedback on these findings was an opportunity to draw their attention to some aspects of the selection process in order to improve it.

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Section: Introductionsupporting

confidence: 55%

An Original Approach to Evaluating the Quality of Blood Donor Selection: Checking Donor Questionnaires and Analyzing Donor Deferral Rate

Gillet¹,

Neijens²

2018

Front. Med.

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“…The higher seroprevalences of syphilis of 21.51% and 12.7% were observed in Equatorial Guinea [19] and in Tanzania [30]. These variations in the seroprevalences of syphilis can be due on one hand, to the differences of sensitivity and specificity of the diagnostic tests used, and on the other hand to sexual behaviors, accessibility to health care, matrimonial practices, sample size during surveys and donor selection criteria [31]. The seroprevalence of syphilis was not associated with the sex and age of the blood donors.…”

Section: Discussionmentioning

confidence: 99%

Trends of blood-borne infectious diseases in a rural blood donation center of southeast Gabon (Koula-Moutou)

Bisseyé¹,

Mombo²,

Bie³

et al. 2018

Pan Afr Med J

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Introduction Blood-borne pathogens such as human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) viruses and Treponema pallidum remain a major public health problem in sub-Saharan Africa. The purpose of this study was to assess the frequency and clinical implications of HIV, HBV, HCV and Treponema pallidum markers in blood donors in a rural area of Southeast Gabon (Koula-Moutou) from 2012 to 2017. Methods Hepatitis B surface antigen (HBsAg), anti-HIV, anti-HCV and anti- Treponema pallidum antibodies were screened using rapid diagnostic tests (RDTs). Results Of a total of 5,706 blood donors, 1,054 (18.5%) were seropositive for at least one infectious marker and 59 (5.6%) had serologic evidence of multiple infections. The overall seroprevalence of HIV, HBsAg, HCV, and syphilis was 3.1%; 5.9%; 6.2% and 3.3%, respectively. HIV, syphilis and HCV distributions were associated with neither the sex nor the age of the donors. Only HBsAg seroprevalence was significantly higher in donors of the age group 26-35 years old compared to donors of the age group 36-45 years (OR = 1.43 (95% CI: 1.01-2.04), P = 0.045). There was a significant increase in the frequencies of HIV and syphilis and a regression of HBsAg and HCV among blood donors. Conclusion This study presents the epidemiology of the main pathogens detected in blood donors in a rural area in Gabon. We found that the overall distribution of transfusion transmitted infectious diseases were lower than those observed in the general population but could be underestimated due to the use of RDTs in the screening process of the blood donations.

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“…(2) However, prevalence estimates over the past 20 years have mostly relied on studies conducted in the capital Dakar in specific adult populations, including pregnant women, (8,9) persons coinfected with human immunodeficiency virus (HIV), (10,11) and blood donors. (12)(13)(14) Although two studies targeted children, both were conducted before 2016 in health care facilities in Dakar. (15,16) To fight the HBV epidemic, Senegal has implemented several control measures.…”

mentioning

confidence: 99%

Hepatitis B in Senegal: A Successful Infant Vaccination Program but Urgent Need to Scale Up Screening and Treatment (ANRS 12356 AmBASS survey)

et al. 2021

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Senegal introduced the infant hepatitis B virus (HBV) vaccination in 2004 and recently committed to eliminating hepatitis B by 2030. Updated epidemiological data are needed to provide information on the progress being made and to develop new interventions. We estimated the prevalence of hepatitis B surface antigen (HBsAg) in children and adults living in rural Senegal and assessed hepatitis B treatment eligibility. A cross‐sectional population‐based serosurvey of HBsAg was conducted in 2018‐2019 in a large sample (n = 3,118) of residents living in the Niakhar area (Fatick region, Senegal). Individuals positive for HBsAg subsequently underwent clinical and biological assessments. Data were weighted for age and sex and calibrated to be representative of the area’s population. Among the 3,118 participants, 206 were HBsAg positive (prevalence, 6.9%; 95% confidence interval [CI], 5.6‐8.1). Prevalence varied markedly according to age group in individuals aged 0‐4, 5‐14, 15‐34, and ≥35 years as follows: 0.0% (95% CI, 0.00‐0.01); 1.5% (95% CI, 0.0‐2.3); 12.4% (95% CI, 9.1‐15.6); and 8.8% (95% CI, 6.1‐11.5), respectively. Of those subsequently assessed, 50.9% (95% CI, 41.8‐60.0) had active HBV infection; 4 (2.9%; 95% CI, 0.9‐9.4) were eligible for hepatitis B treatment. Conclusion: In this first population‐based serosurvey targeting children and adults in rural Senegal, HBsAg prevalence was very low in the former, meeting the World Health Organization’s (WHO) < 1% HBsAg 2020 target; however, it was high in young adults (15‐34 years old) born before the HBV vaccine was introduced in 2004. To reach national and WHO hepatitis elimination goals, general population testing (particularly for adolescents and young adults), care, and treatment scale‐up need to be implemented.

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Évaluation de l’efficacité de la sélection médicale des donneurs de sang dans la prévention des agents infectieux

Cited by 11 publications

References 14 publications

An Original Approach to Evaluating the Quality of Blood Donor Selection: Checking Donor Questionnaires and Analyzing Donor Deferral Rate

An Original Approach to Evaluating the Quality of Blood Donor Selection: Checking Donor Questionnaires and Analyzing Donor Deferral Rate

Trends of blood-borne infectious diseases in a rural blood donation center of southeast Gabon (Koula-Moutou)

Hepatitis B in Senegal: A Successful Infant Vaccination Program but Urgent Need to Scale Up Screening and Treatment (ANRS 12356 AmBASS survey)

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