Urachal Carcinoma of the Bladder: Impact of Clinical and Immunohistochemical Parameters on Prognosis

Niedworok, Christian; Panitz, Martin; Szarvas, Tibor; Reis, Henning; Reis, Anna Carinna; Szendrői, Attila; Nyírády, Péter; Szász, Attila Marcell; Módos, Orsolya; Rübben, H.; Dorp, F. vom

doi:10.1016/j.juro.2015.11.067

Cited by 34 publications

(35 citation statements)

References 25 publications

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“…This suggests that LND might be beneficial for UrC patients. In contrast to this assumption, studies reported so far found no survival benefit for those patients who underwent LND [10,12,24]. It is, however, important to note that-in the lack of randomization-decisions on the performance of LND were done on a rather subjective and individual basis, therefore these comparisons cannot be considered as reliable.…”

Section: Staging Systemsmentioning

confidence: 91%

“…Data on Sheldon staging were available in case of 532 UrC patients showing an uneven distribution of cases. Only 3 cases were staged as Sheldon I (0.6%), 40 were Stage II (8%), 363 Stage III (68%), and 126 stage IV (24%) [3,10,12,14,[18][19][20]24,26,27,30,31] (Table 3). Overall, 6 studies classified a total number of Tumor infiltrating the regional lymph node Stage IV Tumor infiltrating non-regional lymph nodes or other distant sites (Table 3).…”

Section: Staging Systemsmentioning

confidence: 99%

“…Therefore, we restricted our comparative analysis only to those studies including at least 25 patients. After this restriction, 10 studies comprising 620 UrC patients remained in the comparison [10,12,[18][19][20][21][22][23][24]28].…”

Section: Survivalmentioning

confidence: 99%

“…The presence of LN and distant metastases were consequently associated with poor prognosis [12,23,28]. Information on surgical margin status was available in 4 studies and was constantly identified as a significant risk factor, underlining the importance of the complete tumor resection [10,12,23,24]. However, the performance of radical cystectomy compared with partial cystectomy provided no survival benefit [10,24].…”

Section: Survivalmentioning

confidence: 99%

See 3 more Smart Citations

Clinical, prognostic, and therapeutic aspects of urachal carcinoma—A comprehensive review with meta-analysis of 1,010 cases

Szarvas

Módos

Niedworok

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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130

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Section: Staging Systemsmentioning

confidence: 91%

Section: Staging Systemsmentioning

confidence: 99%

Section: Survivalmentioning

confidence: 99%

Section: Survivalmentioning

confidence: 99%

See 2 more Smart Citations

Clinical, prognostic, and therapeutic aspects of urachal carcinoma—A comprehensive review with meta-analysis of 1,010 cases

Szarvas

Módos

Niedworok

et al. 2016

Urologic Oncology: Seminars and Original Investigations

Self Cite

130

193

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“…En estos casos no existe un manejo estándar, por lo que se refiere en la literatura el uso de quimioterapia y radioterapia como terapia coadyuvante (13) , pero a cinco años la supervivencia en este tipo de paciente no supera el 20% (12,14) .…”

Section: Discussionunclassified

Carcinoma de uraco, una neoplasia maligna poco frecuente

Salazar¹,

Silva

Hernández

2018

RMU

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ResumenEl carcinoma de uraco es una neoplasia maligna poco frecuente de predominio masculino entre la quinta a sexta dé-cada de la vida. Se localizan típicamente en la cúpula de la vejiga, con patrón histopatológico predominante de adenocarcinoma en el 90% de los casos. Tiene un curso indolente con manifestaciones clínicas en etapas tardías caracterizadas por hematuria, dolor abdominal, disuria, mucosuria, entre otros. El diagnóstico se basa en el hallazgo de la lesión por métodos endoscópicos e imagenológicos. Dado lo infrecuente de esta patología, se describe el caso de una paciente en su cuarta década de vida con infección de vías urinarias recurrente, en quien se documentó por medio de urografía por tomografía computarizada multicorte (UROTAC) de pólipo vesical resecado por resección transuretral (RTU) con reporte histológico de adenocarcinoma de tipo entérico. Palabras clave: CARCINOMA DE URACO PRUEBAS DIAGNÓSTICAS DE RUTINA Key words:URACHAL CARCINOMA ROUTINE DIAGNOSTIC TESTS IntroducciónEl carcinoma de uraco es una neoplasia maligna que corresponde al 0,7% de todos los cánceres de vejiga y al 35% de adenocarcinomas vesicales (1) . Es más frecuente en hombres con una relación 5: 1 (2,15) , de predominio entre la quinta a sexta década de la vida (3) . En cuanto a su origen, el uraco es una estructura de 5 a 10 cm de longitud proveniente de la alantoides, que pasa desde la cúpula vesical hasta el ombligo y se convierte en un cordón fibroso obliterado en el adulto (4) . Se constituye de tres capas: una externa constituida por músculo liso, una intermedia constituida por tejido conectivo submucosa y una interna de tipo luminal. De las anteriores, las células epiteliales que constituyen cada capa dan lugar al carcinoma de uraco (5) . Caso clínicoPaciente mujer en su cuarta década de vida, presenta dos años con síntomas urinarios irritativos y mucosuria con infección de vías urinarias recurrentes, se indicó tratamiento antibiótico guiado por urocultivo. Se realizó UROTAC con hallazgo de lesión polipoide en vejiga de 22 mm. Posteriormente es llevada a cistoscopía, documentando hallazgo anterior en cúpula vesical, la cual es removida a través de RTU con reporte de histopatología de adenocarcinoma de tipo entérico. Se llevó a junta de oncología donde se conceptuó manejo para carcinoma de uraco a través de cirugía, por lo que se realizó cistectomía parcial más resección de seno uracal y linfadenectomía radical pélvica. Dos meses posteriores a la intervención quirúrgica, presentó dolor severo suprapúbico e inguinal, con sospecha de recaída 52

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Urachal carcinoma: Impact of recurrence pattern and lymphadenectomy on long‐term outcomes

et al. 2020

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Background Urachal carcinoma is a rare nonurothelial malignant tumor with high rates of local recurrence and systemic metastasis. Although radical resection is widely considered the standard treatment, there is still a debate regarding the benefits of lymphadenectomy. To explore these factors, we investigated the recurrence pattern of urachal cancer and the impact of lymphadenectomy on long‐term survival. Methods The data of 62 patients pathologically diagnosed with urachal carcinoma at Sun Yat‐sen University Cancer Center from 2002 to 2019 were retrospectively reviewed. Lymphadenectomy was defined as lymph nodes retrieved from the obturator, internal iliac, and external iliac lymph node stations. The Kaplan‐Meier method and Cox regression model were used to identify prognostic factors. OS and DFS were the primary endpoints. Results Of the 47 males and 15 females included, 54 patients underwent partial cystectomy, and 27 patients underwent lymphadenectomy. The number of patients with Sheldon stage IIIA, IIIB, IIIC, IVA, and IVB were 43 (69.4%), 4 (6.5%) 3 (4.8%), 6 (9.7%), and 6 (9.7%), respectively. The median DFS was 32.7 months, and the mean OS was 114.6 months. Sheldon stage (P < .001) and tumor size (P = .001) were identified as independent prognostic factors for DFS, whereas Sheldon stage (P = .003), peritoneal metastasis (P = .006), distant metastasis (P = .024), and recurrence in pelvic lymph nodes (P = .015) were independent prognostic factors for OS. Conclusions Urachal carcinoma has a high recurrence rate, but only peritoneal metastasis, distant metastasis, and recurrence in pelvic lymph nodes were found to be associated with OS. Lymphadenectomy was recommended because of its role in accurately staging the disease, and further research is needed to focus on lymphadenectomy and standardized the procedure.

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Urachal Carcinoma of the Bladder: Impact of Clinical and Immunohistochemical Parameters on Prognosis

Cited by 34 publications

References 25 publications

Clinical, prognostic, and therapeutic aspects of urachal carcinoma—A comprehensive review with meta-analysis of 1,010 cases

Clinical, prognostic, and therapeutic aspects of urachal carcinoma—A comprehensive review with meta-analysis of 1,010 cases

Carcinoma de uraco, una neoplasia maligna poco frecuente

Urachal carcinoma: Impact of recurrence pattern and lymphadenectomy on long‐term outcomes

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