Transepidermal water loss measurement during infancy can predict the subsequent development of atopic dermatitis regardless of filaggrin mutations

Horimukai, Kenta; Morita, Kumiko; Narita, Masami; Kondo, Mai; Kabashima, Shigenori; Inoue, Eisuke; Sasaki, Takashi; Niizeki, Hironori; Saito, Hirohisa; Matsumoto, Kenji; Ohya, Yukihiro

doi:10.1016/j.alit.2015.09.004

Cited by 98 publications

(91 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Defects in claudins 1, 4 and 8 have also been associated with the development of atopic dermatitis 4–7 . Disruption of the skin barrier involves defects in the entire keratinocyte terminal differentiation program via dysregulation of multiple EDC genes on human chromosome region 1q21 8 , reduced expression of epithelial tight junction proteins 9 , increased transepidermal water loss (TEWL) 10, 11 , and reduction in epidermal natural moisturizing factors 12 . The impaired skin barrier function in AD also involves altered lipid profiles, including shortening of carbon chain length of stratum corneum lipids (ceramides and free fatty acids), an event that exhibits strong correlations with TEWL and occurs independently of filaggrin mutations 13–16 .…”

Section: Barrier Defects In Type 2 Diseasesmentioning

confidence: 99%

“…Strikingly, only 30% to 40% of cases of allergic disease (asthma, eczema, allergic rhinitis) in early childhood are attributable to atopy and 60% to 70% of cases result from yet unknown factors 128 . In most “atopic march” cases, increased skin permeability at birth and non-atopic eczema frequently predate development of atopy 11, 127 , regardless of filaggrin mutations 10 . Moreover, although the atopic march assumes that one allergic disease brings risk of acquisition of another allergic disease later in life, it may involve sensitization to antigens different from those that triggered the initial disease 129, 130 .…”

Section: Mechanisms Of Barrier Defectsmentioning

confidence: 99%

See 1 more Smart Citation

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Schleimer

Berdnikovs

2017

Journal of Allergy and Clinical Immunology

134

122

View full text Add to dashboard Cite

Epithelial barriers of the skin, gastrointestinal tract and airway serve common critical functions such as maintaining a physical barrier against environmental insults and allergens, as well as providing a tissue interface balancing the communication between the internal and external environments. We now understand that in allergic disease, regardless of tissue location, the homeostatic balance of the epithelial barrier is skewed towards loss of differentiation, reduced junctional integrity and impaired innate defense. Importantly, epithelial dysfunction characterized by these traits appears to pre-date atopy and development of allergic disease. Despite our growing appreciation of the centrality of barrier dysfunction in the initiation of allergic disease, many important questions remain to be answered regarding the mechanisms disrupting the normal barrier function. Although our external environment (proteases, allergens, injury) is classically thought of as a principal contributor to barrier disruption associated with allergic sensitization, there is a need to better understand contributions of the internal environment (hormones, diet, circadian clock). Systemic drivers of disease, such as alterations of the endocrine system, metabolism and aberrant control of developmental signaling, are emerging as new players in driving epithelial dysfunction and allergic predisposition at various barrier sites. Identifying such central mediators of epithelial dysfunction, using both systems biology tools and causality-driven laboratory experimentation, will be essential in building new strategic interventions to prevent or reverse the process of barrier loss in allergy.

show abstract

Section: Barrier Defects In Type 2 Diseasesmentioning

confidence: 99%

Section: Mechanisms Of Barrier Defectsmentioning

confidence: 99%

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Schleimer

Berdnikovs

2017

Journal of Allergy and Clinical Immunology

134

122

View full text Add to dashboard Cite

show abstract

“…By hydrating the SC, moisturizers can alleviate the xerosis that is such a prominent feature of AD, but they have not yet been shown to provide stand-alone therapy for even mild cases of AD. Moreover, whether they even prevent the initial development of AD, as suggested in several recent studies [30, 31], is debatable, because another study has failed to show any preventive benefits of moisturizer therapy alone [32]. …”

Section: The Role Of Brt In Admentioning

confidence: 99%

Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis

Elias¹,

Wakefield²,

Man³

2018

Skin Pharmacol Physiol

View full text Add to dashboard Cite

We compare here the principal characteristics of over-the-counter moisturizers with physiologic lipid-based barrier repair therapy. Moisturizers are standard ancillary therapy for anti-inflammatory skin disorders, like atopic dermatitis (AD), and can attenuate the emergence of AD, the initial step in the “atopic march.” But not all moisturizers are beneficial; some can make skin function worse, and can even induce inflammation, possibly accounting for the frequent occurrence of “sensitive skin” in women. In contrast, physiologic lipid-based barrier repair therapy, if comprised of the 3 key stratum corneum lipids, in sufficient quantities and at an appropriate molar ratio, can correct the barrier abnormality and reduce inflammation in AD, and perhaps in other inflammatory dermatoses.

show abstract

“…Table 1). Whether they prevent the initial development of AD, as shown in several studies 25, 26 , is also debatable, since another study failed to show any preventive benefits of moisturizers 27 .…”

Section: Can Moisturizers Alone Alleviate Ad?mentioning

confidence: 99%

Does moisturizing the skin equate with barrier repair therapy?

Elias

Sugarman

2018

Annals of Allergy, Asthma & Immunology

View full text Add to dashboard Cite

Transepidermal water loss measurement during infancy can predict the subsequent development of atopic dermatitis regardless of filaggrin mutations

Abstract: TEWL of the forehead during the first week of life is associated with AD development.

Cited by 98 publications

References 28 publications

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis

Does moisturizing the skin equate with barrier repair therapy?

Contact Info

Product

Resources

About