Urinary heavy metals in Hispanics 40–85 years old in Doña Ana County, New Mexico

Adams, Scott V.; Barrick, Brian; Christopher, Emily P.; Shafer, Martin M.; Song, Xiaoling; Vilchis, Hugo; Newcomb, Polly A.; Ulery, April

doi:10.1080/19338244.2015.1129301

Cited by 13 publications

(7 citation statements)

References 39 publications

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“…Thirty full-text articles were reviewed for further assessment. Five articles were excluded because they were duplicate publications [ 14 , 15 , 22 , 24 , 28 ]; another five were excluded because Cd content was measured [ 33 – 37 ], three studies were excluded because the outcome was gestational diabetes mellitus [ 17 , 18 , 25 ], three were reviews [ 38 – 40 ], two were excluded because outcomes were related to chronic kidney disease [ 41 ] or renal glomerular damage [ 42 ] and one was excluded because the exposure was Cd in the toenail [ 13 ]. Finally, eleven studies met meta-analysis criteria and were included (Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis

Song

Zhu³

et al. 2017

Oncotarget

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Cadmium (Cd) is a pollutant with multiple adverse health effects: cancer, renal dysfunction, osteoporosis and fracture, and cardiovascular disease. Several population-based studies found an association between Cd and diabetes mellitus (DM), but this association is inconsistent with other research. We conducted meta-analysis to examine relationship between urinary/blood Cd exposure and DM risk. Pertinent studies were identified by searching PubMed and Embase databases, and combined odds ratio (OR) and corresponding 95% confidence interval (CI) were applied to evaluate said association. Meta-analysis showed that high U-Cd exposure is not correlated with DM risk (OR = 1.19; 95% CI = 0.83–1.71), and high B-Cd exposure is also not associated with increased risk of DM (OR = 1.16; 95% CI = 0.84-1.62) in the general population. Subgroup and sensitivity analysis proved similar results, with little evidence of publication bias. This meta-analysis suggests that high U-Cd/B-Cd exposure may not be risk factor for DM in general populations. However, large prospective studies are needed to confirm this finding.

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Section: Resultsmentioning

confidence: 99%

Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis

Song

Zhu³

et al. 2017

Oncotarget

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“…iAs is a naturally occurring element in the earth's crust and both humans and wildlife are exposed to iAs through food and water. Estimates of over 100-million people worldwide are exposed to levels exceeding World Health Organization (WHO)-established limits ( Adams et al, 2016 ; Farzan et al, 2016 ; Yang et al, 2009 ). The first prospective cohort study of people chronically exposed to arsenic has revealed an increase in all-cause and chronic disease mortalities ( Ahsan et al, 2006 ; Argos et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish

Bambino

Zhang

Austin

et al. 2018

Disease Models &Amp; Mechanisms

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The rapid increase in fatty liver disease (FLD) incidence is attributed largely to genetic and lifestyle factors; however, environmental toxicants are a frequently overlooked factor that can modify the effects of more common causes of FLD. Chronic exposure to inorganic arsenic (iAs) is associated with liver disease in humans and animal models, but neither the mechanism of action nor the combinatorial interaction with other disease-causing factors has been fully investigated. Here, we examined the contribution of iAs to FLD using zebrafish and tested the interaction with ethanol to cause alcoholic liver disease (ALD). We report that zebrafish exposed to iAs throughout development developed specific phenotypes beginning at 4 days post-fertilization (dpf), including the development of FLD in over 50% of larvae by 5 dpf. Comparative transcriptomic analysis of livers from larvae exposed to either iAs or ethanol revealed the oxidative stress response and the unfolded protein response (UPR) caused by endoplasmic reticulum (ER) stress as common pathways in both these models of FLD, suggesting that they target similar cellular processes. This was confirmed by our finding that arsenic is synthetically lethal with both ethanol and a well-characterized ER-stress-inducing agent (tunicamycin), suggesting that these exposures work together through UPR activation to cause iAs toxicity. Most significantly, combined exposure to sub-toxic concentrations of iAs and ethanol potentiated the expression of UPR-associated genes, cooperated to induce FLD, reduced the expression of as3mt, which encodes an arsenic-metabolizing enzyme, and significantly increased the concentration of iAs in the liver. This demonstrates that iAs exposure is sufficient to cause FLD and that low doses of iAs can potentiate the effects of ethanol to cause liver disease.This article has an associated First Person interview with the first author of the paper.

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“…Similar trends have been previously reported in the Maternal-Infant Research on Environmental Chemicals (MIREC) pregnancy cohort of Canadian women, such that statistically significant associations between women’s age and increased urinary and blood As were observed. 52 , 65 Age-related increases in urinary As and iAs have been observed in other adult populations in the U.S., including in a population of older low-income Hispanic adults in New Mexico 66 and a population of older adults residing in Nevada. 67 …”

Section: Discussionmentioning

confidence: 84%

Demographic predictors of urinary arsenic in a low-income predominantly Hispanic pregnancy cohort in Los Angeles

Farzan

Howe

Chavez

et al. 2020

J Expo Sci Environ Epidemiol

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Background Arsenic (As) is a contaminant of top public health concern, due to its range of detrimental health effects. Arsenic exposure has not been well-characterized among the US Hispanic populations and has been particularly understudied in this population during pregnancy. Methods As part of the MADRES ongoing pregnancy cohort of predominantly lower-income, Hispanic women in Los Angeles, CA, we examined levels of maternal first trimester urinary As, including total As and As metabolites (inorganic (iAs), monomethylated (MMA) and dimethylated As (DMA)), in relation to participant demographics, lifestyle characteristics, and rice/seafood consumption, to identify factors that may influence As exposure and its metabolites during pregnancy (N = 241). Results Total As concentrations ranged from low to high (0.8-506.2 μg/L, mean: 9.0 μg/L, SD: 32.9) in our study population. Foreign-born Hispanic women had 8.6% higher %DMA (95% CI: 3.3%, 13.9%) and −7.7% lower %iAs (95% CI: −12.6%, −2.9%) than non-Hispanic women. A similar trend was observed for US-born Hispanic women. In addition, maternal age was associated with 0.4% higher %iAs (95% CI: 0.1%, 0.6%) and 0.4% lower %DMA (95% CI: −0.7%, −0.1%) per year, which may indicate poor As methylation capacity. Conclusion Individual factors may predict As exposure and metabolism in pregnancy, and in turn, greater risk of adverse health effects.

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Urinary heavy metals in Hispanics 40–85 years old in Doña Ana County, New Mexico

Cited by 13 publications

References 39 publications

Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis

Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis

Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish

Demographic predictors of urinary arsenic in a low-income predominantly Hispanic pregnancy cohort in Los Angeles

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