Operator dependent factors implicated in failure of non‐invasive positive pressure ventilation (NIPPV) for respiratory failure

Abstract

Excluding progression of underlying disease, operator dependent factors linked to NIPPV failure are; inappropriate indication, lack of adequate titration and an overlooked contraindication. Inappropriate utilization of NIPPV in respiratory failure is associated with higher mortality.

Role of B-Type Natriuretic Peptide in Predicting In-Hospital Outcomes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Preserved Left Ventricular Function: A 5-Year Retrospective Analysis

“…2,6,14 Our results could be significantly influenced by the changes in ICU practices, management of patients with hypercapnia, operator dependency on MV, variations in ventilatory settings, and patient/provider preferences. [51][52][53][54][55] B-type natriuretic peptide is typically influenced by age, gender, and obesity in addition to renal function; however, these cohorts were not individually evaluated in our patient population. 48,51 Despite a detailed analysis in patients without renal dysfunction, we are unable to comment on the complex interplay of cardiopulmonary interactions with renal failure including the role of loading conditions, myocardial stretch, timing of echocardiography, and the progression of renal dysfunction all of which could potentially influence BNP levels and the assessment of clinical outcomes.…”

“…[51][52][53][54][55] B-type natriuretic peptide is typically influenced by age, gender, and obesity in addition to renal function; however, these cohorts were not individually evaluated in our patient population. 48,51 Despite a detailed analysis in patients without renal dysfunction, we are unable to comment on the complex interplay of cardiopulmonary interactions with renal failure including the role of loading conditions, myocardial stretch, timing of echocardiography, and the progression of renal dysfunction all of which could potentially influence BNP levels and the assessment of clinical outcomes. We are unable to comment on the implications of an elevated BNP on patient management, such as the use of diuretics and the need for cardiovascular consultation, that were performed at the discretion of the treating physicians.…”

NT-pro BNP in AECOPD-PH: old biomarker, new insights-based on a large retrospective case-controlled study

“…NT-proBNP is typically influenced by age, gender, and obesity in addition to renal function [ 17 ], in our research, first, we excluded the patients with renal insufficiency, then data analysis indicated age and gender indeed had a significant difference between COPD group and AECOD-PH group, however, BMI had no significant difference (P > 0.05), it might be associated with low distribution of obesity in China. We and other studies revealed low NT-proBNP levels in stable COPD patients [ 18 ].…”

Risk factors of unfavorable outcomes in chronic obstructive pulmonary disease patients treated with noninvasive ventilation for acute hypercapnic respiratory failure

“…Noninvasive ventilation (NIV) is commonly used as a support method for patients with acute hypercapnic respiratory failure due to chronic obstructive pulmonary disease (COPD) 1,2 . The utilization of NIV prevents need for intubation, decreases mortality, morbidity and length of hospital stay 1,3 . NIV failure has been described as need for endotracheal intubation due to lack of improvement in arterial blood gases parameters and clinical status of patient or death 4 .…”

“…Recently, NIV can be performed successfully at intensive care units (ICU), respiratory intermediate care units, wards and sometimes at emergency rooms 6 . There are strong evidences for application of NIV in the ICU for severely ill patients, that all patients require close monitoring 3,6,8,9 …”